The present invention provides a pneumatic tire for a motorcycle, in which tire durability at a relatively high speed in running straight is enhanced with maintaining good gripping performances in cornering situation by optimizing the distribution of loss tangent in tread rubbers constituting a tread portion. The pneumatic tire for a motorcycle includes a pair of bead portions 1 having bead cores embedded therein, a pair of sidewalls 2 extending on the outer side in the tire radial direction from the bead portions 1, and a tread portion 3 extending over the respective sidewall portions 2, wherein the tread portion 3 is constituted of at least four tread regions such that, when the tread regions are viewed in a section in the tire widthwise direction, loss tangent values of rubbers constituting the adjacent tread regions are different from each other, and a loss tangent value of a rubber constituting a center tread region 5 as a tread region including the tire equatorial plane 4, of the tread regions, is smaller than a loss tangent value of each of rubbers constituting other tread regions 6.