The invention relates to a high-altitude high-voltage isolation switch electric operating mechanism box, and the box comprises a box body, a top cover, an air-bag type top surface sealing strip, a double-layer door, an outer door frame, an outer door, an inner door frame, an inner door, and an automatic door closer hinge. The top of the box body is connected with the top cover through a fastening part, and at least one side of the periphery of the box body is provided with the double-layer door. The double-layer door comprises the outer door frame, the inner door frame, the outer door and the inner door. The outer door frame is disposed on the box body, and is connected with the box body through a hinge. The outer door achieves the sealing fit with the outer door frame. The inner door frame is disposed in the outer door frame, and the inner door is connected with the outer door frame through the automatic door closer hinge. The inner door achieves the sealing fit with the inner door frame. The box is simple in structure, is good in sealing effect, is high in reliability, is resistant to a low-temperature environment, is convenient to operate and maintain, and is also convenient for popularization and application.