The invention relates to the technical field of pharmaceutical preparations, in particular to a polyphosphoester
polymer, a preparation method thereof, modified
porous silicon nanoparticles and a preparation method and application of modified the
porous silicon nanoparticles. A main chain of the polyphosphoester
polymer is a polyphosphoester
chain segment, side chains of the polyphosphoester
polymer are amphoteric ionic chain segments, good
biocompatibility and degradability are achieved, the polyphosphoester polymer is introduced into the surfaces of the
porous silicon nanoparticles, thus thestability of
nanoparticle colloids can be improved significantly, the polyphosphoester polymer penetrates through
mucus more rapidly, the retention volume of the nanoparticles on a
mucous layer is decreased, better affinity to epithelial cells is achieved, the
endocytosis amount of the cells is greatly increased,
intracellular and
extracellular drug release can be effectively conducted in a transcellular mode, and the
bioavailability of drugs is improved advantageously; meanwhile, active sites of the polyphosphoester chain segments in the polyphosphoester polymer are easily coupled with targeted factors, the affinity of hydrophilic polyphosphoester chain segments and a
cell membrane are high, and compared with existing nanoparticles for promoting
mucus diffusion, the safety of the nanoparticles can be effectively improved.