The invention relates to preparation and application of a reusable
drug carrier with magnetic targeting
drug delivery, namely a magnetic
graphene oxide compound. The preparation of the magnetic
graphene oxide compound comprises the following steps: (1) taking a
graphite powder, adding a concentrated H2SO4 solution with NaNO3 dissolved therein, stirring, adding KMnO4, reacting, adding
distilled water for
dilution, keeping warm, cooling to
room temperature, adding H2O2 to react, conducting suction
filtration, washing respectively with diluted
hydrochloric acid and
distilled water, carrying out
vacuum drying to obtain
graphite oxide; dispersing
graphite oxide in deionized water, and carrying out ultrasonic exfoliation at
room temperature to obtain a GO suspension; (2) respectively weighing
ferrous salt and
ferric salt and dissolving in deionized water to obtain a solution A; and (3) taking a GO suspension, adding
distilled water for
dilution, adjusting to acid, dropwise adding the solution A obtained in the step (2) so as to obtain a
mixed solution B, carrying out constant temperature curing on the
mixed solution B, adjusting to alkaline,
ageing for several hours, carrying out
magnetic separation to obtain a
solid crude product, washing the
solid crude product to neutral, and carrying out
vacuum drying to obtain the product.