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Preparation and application of magnetic graphene oxide compound

An oxide stone and composite technology, which is applied in the directions of alkali metal compounds, alkali metal oxides/hydroxides, chemical instruments and methods, etc., can solve the problems of insufficient capacity and insufficient guidance, and achieves easy availability of raw materials and low cost of raw materials. , the effect of mild preparation conditions

Active Publication Date: 2015-10-28
ZHEJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the shortcomings of insufficient drug-loading capacity and insufficient orientation of current drug carriers, and provides a reusable drug carrier with magnetic targeted drug delivery, that is, the preparation and application of magnetic graphene oxide composites

Method used

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  • Preparation and application of magnetic graphene oxide compound
  • Preparation and application of magnetic graphene oxide compound
  • Preparation and application of magnetic graphene oxide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: m G / F =1:2 preparation and application of magnetic graphene oxide composite

[0041] 1.m G / F =1:2 Preparation of Magnetic Graphene Oxide Composite

[0042] ⑴Weigh 0.23g graphite powder, add 50mL dissolved in 0.25g NaNO 3 Concentrated H 2 SO 4 solution, after stirring for 20min, slowly add 6g KMnO 4 After reacting at 35°C for 2 hours, raise the temperature to 80°C, keep warm for 15min, add 200mL distilled water to dilute, heat to boiling and keep warm for 15min, then cool down to room temperature, add 10mL H 2 o 2 After reacting for 6 hours, the solid crude product obtained by suction filtration was centrifuged and washed with dilute hydrochloric acid and distilled water until there was no SO in the centrifuged liquid. 4 2- ; The washed solid was vacuum-dried at 60°C for 12 hours to obtain graphite oxide; 0.2 g of graphite oxide powder was dispersed in 400 mL of deionized water, and ultrasonically stripped at room temperature for 4 hours to obtain a GO...

Embodiment 2

[0047] Example 2: m G / F =1:4 preparation and application of magnetic graphene oxide composite

[0048] 1.m G / F =1:4 Preparation of Magnetic Graphene Oxide Composite

[0049] ⑴Weigh 0.23g graphite powder, add 50mL dissolved in 0.25g NaNO 3 Concentrated H 2 SO 4 solution, after stirring for 20min, slowly add 6g KMnO 4 After reacting at 35°C for 2 hours, raise the temperature to 80°C, keep warm for 15min, add 200mL distilled water to dilute, heat to boiling and keep warm for 15min, then cool down to room temperature, add 10mL H 2 o 2 After reacting for 6 hours, the solid crude product obtained by suction filtration was centrifuged and washed with dilute hydrochloric acid and distilled water until there was no SO in the centrifuged liquid. 4 2- ;The washed solid was vacuum-dried at 60°C for 12h to obtain graphite oxide; 0.2g of graphite oxide powder was dispersed in 400mL of deionized water, and ultrasonically peeled at room temperature for 4h to obtain a GO suspension wit...

Embodiment 3

[0054] Example 3: m G / F =1:6 preparation and application of magnetic graphene oxide composite

[0055] 1.m G / F =1:6 Preparation of Magnetic Graphene Oxide Composite

[0056] ⑴Weigh 0.23g graphite powder, add 50mL dissolved in 0.25g NaNO 3 Concentrated H 2 SO 4 solution, after stirring for 20min, slowly add 6g KMnO 4 After reacting at 35°C for 2 hours, raise the temperature to 80°C, keep warm for 15min, add 200mL distilled water to dilute, heat to boiling and keep warm for 15min, then cool down to room temperature, add 10mL H 2 o 2 After reacting for 6 hours, the solid crude product obtained by suction filtration was centrifuged and washed with dilute hydrochloric acid and distilled water until there was no SO in the centrifuged liquid.4 2- ;The washed solid was vacuum-dried at 60°C for 12h to obtain graphite oxide; 0.2g of graphite oxide powder was dispersed in 400mL of deionized water, and ultrasonically peeled at room temperature for 4h to obtain a GO suspension with ...

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Abstract

The invention relates to preparation and application of a reusable drug carrier with magnetic targeting drug delivery, namely a magnetic graphene oxide compound. The preparation of the magnetic graphene oxide compound comprises the following steps: (1) taking a graphite powder, adding a concentrated H2SO4 solution with NaNO3 dissolved therein, stirring, adding KMnO4, reacting, adding distilled water for dilution, keeping warm, cooling to room temperature, adding H2O2 to react, conducting suction filtration, washing respectively with diluted hydrochloric acid and distilled water, carrying out vacuum drying to obtain graphite oxide; dispersing graphite oxide in deionized water, and carrying out ultrasonic exfoliation at room temperature to obtain a GO suspension; (2) respectively weighing ferrous salt and ferric salt and dissolving in deionized water to obtain a solution A; and (3) taking a GO suspension, adding distilled water for dilution, adjusting to acid, dropwise adding the solution A obtained in the step (2) so as to obtain a mixed solution B, carrying out constant temperature curing on the mixed solution B, adjusting to alkaline, ageing for several hours, carrying out magnetic separation to obtain a solid crude product, washing the solid crude product to neutral, and carrying out vacuum drying to obtain the product.

Description

technical field [0001] The invention relates to the technical fields of biomedicine, magnetic materials and carbon materials, and specifically refers to the preparation and application of a reusable drug carrier with magnetic targeted drug delivery, that is, a magnetic graphene oxide compound. Background technique [0002] At present, the simple research and development of new drugs can no longer meet the needs of treatment, mainly due to the following problems: the absorption efficiency of the drug at the lesion is low; the metabolism and degradation of the organism will decompose and digest the drug, making the concentration of the drug acting on the lesion too small ; and the solubility of the drug in the aqueous phase is low when it is administered by injection. The existence of the above-mentioned problems greatly limits the curative effect of medicine. An effective way to solve these problems is to develop a suitable drug carrier, so that the effect of the drug no lon...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K41/00A61K31/704A61K31/4745A61K31/513A61P35/00B01J20/20B01J20/28B01J20/30
Inventor 李良超沈俊海张金敏全微雷冯建涛
Owner ZHEJIANG NORMAL UNIVERSITY
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