38results about How to "Efficient treatment effect" patented technology

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

The invention discloses composite nano-particles used in inorganic photodynamic therapy, and a preparation method thereof. According to the invention, nano-particles with an up-conversion luminescence property under infrared light excitation are composed with TiO2, ZrO2 or Zr-Ti-O nano-particles with good biocompatibility with cell killing property under ultraviolet light irradiation, such that composite nano-particles are prepared. The composite nano-particles can be adopted as a near-infrared-light-excited novel inorganic photodynamic therapy reagent, and has characteristics of good body tissue penetration capacity, good safety, and no damage. Because the particles have nano-grade dimensions, the retention time of the nano-particles in bodies is long, and the nano-particles have stability better than that of traditional organic photo-sensitizers. Therefore, the nano-particles have important application potential in photodynamic therapies of malignant tumors.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

The invention provides a method for preparing a cell group containing a cytokine-induced killing cell, which comprises the following procedure: a cell group containing a cell which can be differentiated into a cytokine-induced killing cell is cultured in the presence of a fibrous connection protein segment. The invention also provides a cell group which contains the cytokine-induced killing cell obtained by the method. The invention also provides a medicine which contains the cell group as an effective constituent. The invention also provides an application of the cell group to the preparation of medicines.

The invention provides an amphiphilic graft copolymer based on hyaluronic acid, and a preparation method and application of the amphiphilic graft copolymer. The copolymer disclosed by the invention comprises hyaluronic acid (HA) serving as a parent skeleton, deoxycholic acid (DCA) grafted on the skeleton, a methoxy polyethylene glycol (mPEG) unit and an N-acetyl-L-cysteine (NAC) group. The invention also provides the preparation method of the copolymer. According to the method, the copolymer is prepared by modifying HA with mPEG, DCA and NAC. The invention also provides a hemostatic sponge, adrug carrier and a pharmaceutical composition prepared from the copolymer. The copolymer is good in biocompatibility, high in water absorption speed and capable of achieving active-and-passive dual targeting and redox conversion, and therefore, the copolymer can be used for preparing the hemostatic sponge capable of realizing rapid water absorption and an anti-cancer drug release carrier, realizesblood circulation prolonging, high uptake and rapid drug release of drugs, effectively increases drug concentrations in tumor cells and has good application prospects.

The invention discloses a preparation method of panax quinquefolius raw powder tablets, and belongs to the technical field of health care products. The method comprises nine steps: sorting, cleaning, drying, crushing, grinding, granulating, mixing, tabletting and sterilizing. The panax quinquefolius raw powder tablets do not contain any auxiliary materials; the bioavailability of product is increased; the product is more convenient to use, with longer guarantee period, lower processing cost, good dispersibility, miscibility and absorbability, thus the effective constituents of panax quinquefolius enter human body quickly; the original taste is reserved, and the health care function is increased; moreover, the dosage can be exponentially reduced, thereby effectively increasing utilization ratio of rare resources.

The invention provides an elastic membrane, and a preparation method and application thereof. The elastic membrane comprises a silicone rubber and a medicine. The medicine is coated inside the silicone rubber in a mode of a medicine storage area, and the medicine comprises estrogen. The elastic membrane achieves an efficient therapeutic effect through micro-release of the medicine, and the medicine release is more stable. The elastic membrane has a longer medicine release cycle and better slow release capacity and is used for treatment of uterine cavity damage in a medicine slow-release system. The method for preparing the elastic membrane is simple, raw materials are easy to obtain, the price is low, and industrial large-scale production application is facilitated.

The invention provides a pharmaceutical composition containing sunitinib as well as a preparation and an application of the pharmaceutical composition. On the basis of the original sunitinib, at leastone tyrosine kinase receptor inhibitor, especially apatinib and / or axitinib, is further added to generate a very significant synergistic effect with the sunitinib, so that the proliferation of cancercells is obviously inhibited, and the sunitinib has very significant killing efficiency on the cancer cells. The pharmaceutical composition provided by the invention can obviously improve the problemof serious drug resistance caused by singly adopting sunitinib in the prior art and the problem of obviously reduced treatment effect when the conventional use amount of sunitinib is reduced; clinical treatment efficiency is greatly improved, treatment toxic and side effects of a patient are reduced, a new scheme is provided for clinical treatment, and the traditional Chinese medicine compositionhas very wide market prospects and extremely important social significance.

The invention discloses a shockwave treatment apparatus. The apparatus comprises a control cabinet, a universal adjustment bracket, a shockwave therapy device and a penis fixing device; one end of theuniversal adjustment bracket is in pivoted fit with the control cabinet, the other end of the universal adjustment bracket is in pivoted fit with the input end of the shockwave therapy device, and the penis fixing device is mounted at the output end of the shockwave therapy device; and the control cabinet controls the shockwave therapy device to intake or exhaust air in order to make the shockwave therapy device generate shockwaves or return. The universal adjustment bracket is arranged to reach the relative fixation of the shockwave therapy device, the direction and the angle are adjusted asneeded, and the penis is clamped by the penis fixing device to realize the long-time relative fixation of the shockwave therapy device and the penis in order to ensure the stable and efficient therapy effect, so the manpower is saved, and inconveniences in the therapy process are reduced.

The invention provides an implant as well as a preparation method and application thereof. The implant comprises an implant suture and a drug coating arranged on the surface of the implant suture, wherein the drug coating comprises a drug and a controlled release factor. According to the implant provided by the invention, the implant can achieve an effect of quantitatively and slowly releasing the drug so as to eliminate or reduce pain, inflammatory swelling, infection and other risks in the implantation process on the basis of ensuring that the implant can be smoothly implanted into the human body, and a high-efficiency treatment effect can be achieved at a small dosage; moreover, by modifying the surface of the implant suture, good adhesion is maintained between the implanted implant suture and the drug coating. The drug coating is sprayed onto the implant suture in a spray manner, so that the drug on the surface of the implant suture can be uniformly dispersed, and convenience is brought to uniform and stable release of the drug. The implant is simple in preparation method, readily available in raw materials and easy to realize and has excellent effects in aspects such as inflammation control and swelling subsidence.

The invention discloses a method for preparing ultrahigh-drug-loaded nanoparticles by a sequential precipitation and complexation coacervation technology. The method comprises the following steps: mixing a first reactant with a second reactant in a first reactor to make active drug components precipitate in the first reactor in order to form a drug nanoparticle core; and allowing the reaction product of the first reactor to rapidly flow into a second reactor and be mixed with a third reactant, and carrying out a complexation coacervation reaction on a shell material to make the shell materialdeposited on the surface of the drug nanoparticle core in order to form the ultrahigh-drug-loaded nanoparticles with a core-shell structure.

The invention relates to a preparation utilizing a compatibility prescription of the effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis. The preparation comprises the following components by mass: 10-15 parts of a rhizoma coptidis effective part's water extract with a berberine content of more than 80%; and a rhizoma drynariae effective part's water extract with a naringin content of more than 30.71%. The preparation can be prepared into a ''rhizoma coptidis-rhizoma drynariae tooth strengthening capsule'' for systemic administration, or can be added with hydroxyethyl cellulose, concentrated glycerol, polyacrylic resin and other auxiliary materials to make a novel topical Chinese medicinal long-acting compound ointment ''rhizoma coptidis-rhizoma drynariae tooth strengthening ointment'', and a syringe administration mode is easy for operation at local parts of a periodontal pocket. With a good therapeutical effect on periodontitis, the preparation provided by the invention has the characteristics of small prescription, significant curative effect, no toxic or side effect. Especially in local application, after long-term use, the anti-inflammatory effect is similar to that of minocycline hydrochloride ointment (Periocline), but the osteogenic effect is obviously superior to that of Periocline. Thus, the preparation is a novel oral Chinese patent medicine with long-term efficacy and usability similar to western medicines.

The invention relates to a slow-release system of a supramolecular structure, in particular to a drug carrier system based on supramolecular recognition self-assembly as well as a preparation method and an application thereof. The drug carrier system provided by the invention is formed by self-assembling beta-glucan and a high-molecular compound with positive charges; wherein the high-molecular compound is selected from polysaccharides, polypeptides or compositions or polymers of polysaccharides and polypeptides. The drug carrier system provided by the invention has important application valuein the aspects of active drug wrapping and delivery.

The invention discloses a traditional Chinese medicine composition for treating or treating bedsores in an adjuvant mode. The traditional Chinese medicine composition is mainly prepared from the following traditional Chinese medicines in parts by weight: 1-5 parts of radix ginseng, 1-10 parts of radix notoginseng, 1-10 parts of radix astragali, 1-5 parts of radix angelicae sinensis, 1-10 parts offlos carthami, 1-10 parts of radix rhei officinale, 1-10 parts of rhizoma polygoni cuspidati, 1-10 parts of radix lithospermi, 1-5 parts of honeysuckle flowers, 1-10 parts of fructus forsythiae, 1-10parts of angelica roots, 1-5 parts of garden burnet roots, 1-10 parts of frankincense, 1-10 parts of myrrh and 10-20 parts of borneol. The drug composition disclosed by the invention adopts common rawmaterials, is simple in preparation method, and has effective and reliable treatment effect for bedsores, especially severe bedsores of grade III or higher. The drug composition disclosed by the invention is stable in property, and has no statistical significance in treatment effect difference for a light patient after being stored for a long time at a high temperature.

The invention discloses composition for promoting wound healing. The composition is prepared from the following medicinal materials in parts by weight: 10 to 30 parts of olibanum, 10 to 30 parts of musk, 10 to 30 parts of myrrh, 10 to 40 parts of centipede, 10 to 40 parts of radix angelicae pubescentis, 10 to 30 parts of flos carthami, 27 to 134 parts of ramulus mori, 20 to 40 parts of cortex dictamni, 30 to 50 parts of squama manis, 5 to 20 parts of radix notoginseng powder, 30 to 50 parts of mercury sulfide ash, 20 to 40 parts of raw radix aconite agrestis, 30 to 50 parts of raw radix aconiti, 5 to 20 parts of herba phrymae leptostachyae and 5 to 20 parts of herba lycopodii. A healing paste prepared from the pharmaceutical composition disclosed by the invention has high-efficiency and reliable treating effects on varieties wounds including varieties of sore symptoms of trauma, red wound, burn, scald, postoperative nonunion, diabetes foot rot, phlebitis foot rot and the like whether infection happens or not.

The invention discloses an application of the milk of a lactating woman taking Wangshi Baochi pills in treating infant diseases. In the invention, an efficient, quick, convenient and safe treatment effect can be realized on infant diseases, and related diseases of the mother and infant also can be treated at the same time.

The invention discloses a recovery plaster for promoting blood circulation to dispel blood stasis. The recovery plaster is prepared by the steps of heating sesame oil in an iron pan, adding mistletoe, adhatoda ventricosa, common gendarussa herb, angelica, Sichuan lovage rhizome, nux vomica, raw kusnezoff monkshood root, raw Sichuan aconite root, safflower, asarum, teasel root, eucommia bark, clematis root, common clubmoss herb, cassia twig, gentiana macrophylla, angelica pubescens, atractylodes, suberect spatholobus stem, Korean pine bark, datura flower and loose knot, filtering herb residue and reserving oil for later use; adding frankincense and myrrh when the oil in the pan is naturally cooled to 75 DEG C, stirring with the oil, adding viscous yellow wax, and heating over small fire to form plaster; and adding azone and chlorpheniramine when the plaster is naturally cooled to 45 DEG C, and uniformly spreading the plaster on the disinfected cotton cloth. By adopting the recovery plaster, an operation is not needed for tissue symptoms around joints; and the recovery plaster realizes quick inflammation and swelling diminishment, has quick response and short treatment course, can relieve the pain of patients and is simple and convenient to use.

The invention provides a phenolic acid polypeptide conjugate as well as a preparation method and application thereof. The phenolic acid polypeptide conjugate is formed by connecting phenolic acid and polypeptide through amido bonds, wherein the phenolic acid mainly comprises gallic acid, rosmarinic acid, ferulic acid, caffeic acid, protocatechuic acid, chlorogenic acid, sinapic acid and vanillic acid; and the amino acid sequence of the polypeptide is KLVFFAED. The preparation method comprises the following steps: (1) synthesizing KLVFFAED polypeptide by using a polypeptide solid-phase synthesis method; (2) under the protection of an inert atmosphere, dissolving a phenolic acid solution, a catalyst and an alkaline reagent into DMF to be coupled and reacted with the resin, and after reaction, cutting off the polypeptide from the resin by using a cutting reagent to obtain a phenolic acid polypeptide conjugate crude product; and (3) separating, purifying and freeze-drying to obtain the phenolic acid polypeptide conjugate. Compared with unmodified phenolic acid, the phenolic acid polypeptide conjugate has the advantages that fat solubility and stability can be improved, so that the phenolic acid polypeptide conjugate can be more easily taken by cells, a targeting effect can be realized, toxic and side effects on normal cells are reduced, and a drug treatment effect is efficiently played.

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

The present invention provides a pharmaceutical composition containing sunitinib and its formulation and application, on the basis of the original sunitinib, further adding at least one tyrosine kinase receptor inhibitor, especially apatinib Nib and / or Axitinib can produce a very significant synergistic effect with it, thereby significantly inhibiting the proliferation of cancer cells, and has a very significant killing efficiency on cancer cells. The pharmaceutical composition provided by the present invention can obviously improve the problem of severe drug resistance caused by the simple use of sunitinib in the prior art and the problem of significantly reduced therapeutic effect when reducing the conventional dosage of sunitinib, greatly It improves the efficiency of clinical treatment, reduces the side effects of treatment for patients, provides a new solution for clinical treatment, and has a very broad market prospect and extremely important social significance.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

A method for preparing ultra-high drug-loaded nanoparticles by means of sequence precipitation-complex coacervation. The method comprises: first, mix a first reactant and a second reactant in a first reaction vessel (1), and then precipitate active pharmaceutical ingredients in the first reaction vessel (1) to form cores of drug nanoparticles; the reaction product in the first reaction vessel (1) quickly flows into a second reaction vessel (2) to mix with a third reactant; and after undergoing a complex coacervation reaction, shell materials are deposited on the surfaces of the cores of drug nanoparticles so as to form ultra-high drug-loaded nanoparticles having a core-shell structure.

The invention belongs to the field of biological medicine, and provides drug-loaded Prussian blue and manganese fibrin composite gel, and a preparation method and application thereof. Mesoporous Prussian blue nanoparticles are etched to form hollow Prussian blue nanoparticles; the hollow Prussian blue nanoparticles are coated with manganese ions to form hollow Prussian blue and manganese nanoparticles; the hollow Prussian blue and manganese nanoparticles are subjected totargeted modification; holes of the hollow Prussian blue and manganese nanoparticles are loaded with a sound-sensitive agent and coated with oligomeric hyaluronic acid; and finally, it is mixed with a fibrinogen solution under the stimulation of thrombin to form the composite gel. According to the invention, the novel sound-sensitive agent is loaded in the holes of the hollow Prussian blue nanoparticles; the oligomeric hyaluronic acid is modified on the outer surface, so that the targeting effect can be achieved, and the immunosuppressive microenvironment of tumors can be adjusted; and the composite gel not only can realize the enhanced sonodynamic-immune synergistic treatment effect on postoperative residual tumor tissues, but also can accelerate the repair and healing of postoperative wounds.

The invention provides an amphiphilic graft copolymer based on hyaluronic acid, its preparation method and application. The copolymer of the present invention includes: hyaluronic acid (HA) as a matrix, deoxycholic acid (DCA) grafted on the backbone, methoxypolyethylene glycol (mPEG) units and N-acetyl-L-half Cystine (NAC) group. The invention also provides a preparation method of the copolymer, wherein the copolymer is prepared by modifying HA with mPEG, DCA and NAC. The invention also provides a hemostatic sponge, a drug carrier and a drug composition prepared from the copolymer. The copolymer of the present invention has good biocompatibility, fast water absorption, active and passive dual targeting and redox conversion, so it can be used to prepare fast water-absorbing hemostatic sponge and anti-cancer drug release carrier, and realize prolonged blood circulation, high intake and Rapid drug release can effectively increase the drug concentration in tumor cells, and has broad application prospects.

The invention discloses a drug for quick treatment of onychomycosis, prepared from, by weight, 35-50 parts of Radix Euphorbiae Fischerianae, 25-40 parts of Radix Notoginseng, 50-65 parts of Rhizoma Imperatae, 42-55 parts of Radix Sophorae Flavescentis, 20-26 parts of alums, 10-15 parts of griseofulvin tablets, 15-22 parts of benzoic acid, and 18-25 parts of boric acid. The drug can treat both symptoms and root causes, can treat onychomycosis from the root, with low recurrence rate after healing, and has high acting speed and low side effect.

The invention discloses composite nano-particles used in inorganic photodynamic therapy, and a preparation method thereof. According to the invention, nano-particles with an up-conversion luminescence property under infrared light excitation are composed with TiO2, ZrO2 or Zr-Ti-O nano-particles with good biocompatibility with cell killing property under ultraviolet light irradiation, such that composite nano-particles are prepared. The composite nano-particles can be adopted as a near-infrared-light-excited novel inorganic photodynamic therapy reagent, and has characteristics of good body tissue penetration capacity, good safety, and no damage. Because the particles have nano-grade dimensions, the retention time of the nano-particles in bodies is long, and the nano-particles have stability better than that of traditional organic photo-sensitizers. Therefore, the nano-particles have important application potential in photodynamic therapies of malignant tumors.

A preparation for treating periodontitis with a combination prescription of Coptidis Rhizoma and Rhizoma Drynariae effective parts, the raw material components include: 10-15 parts of water extract of Coptidis Rhizoma effective parts containing more than 80% berberine; naringin 30.71 % more than 5-10 parts of drynaria effective parts water extract; made into "Lian Bu Gu Chi Capsule" for systemic administration; or adding hydroxyethyl cellulose, concentrated glycerin, polyacrylic resin and other auxiliary materials to make a The new long-acting compound ointment of traditional Chinese medicine for external use "Lian Bu Gu Te Ointment" is easy to operate in the periodontal pocket by means of syringe administration. The invention has good therapeutic effect on periodontitis. The invention has the characteristics of small prescription, remarkable curative effect and no toxic and side effects. Especially when applied locally, the anti-inflammatory effect of long-term use is similar to that of minocycline hydrochloride ointment (Paileo), but the bone formation effect is obviously better than Paleo. New dosage forms of oral Chinese patent medicines with ease of use.

The invention discloses a medicine for treating primate bacterial diarrhea. The medicine is prepared from the following raw materials in parts by weight: 5-20 parts of calyx-shaped daphniphyllum root, 10-30 parts of red-knees herb, 8-15 parts of the root of kudzu vine, 10-20 parts of scutellaria root, 5-10 parts of coptis chinensis, 10-15 parts of garden burnet, 3-10 parts of elecampane and 20-30 parts of berberine. The adopted medicines refer to traditional Chinese medicines, the traditional Chinese medicines have bactericidal functions, the active ingredients of the traditional Chinese medicines are extracted by virtue of scientific methods, the effects of the used traditional Chinese medicines are combined by virtue of the active ingredients of the traditional Chinese medicines, the bacteria can be inhibited and killed, the medicine disclosed by the invention has a high-efficiency effect of treating primate diarrhea and is high in cure rate, and the immunity of animals can be enhanced. Moreover, because the main components of the medicine disclosed by the invention refer to Chinese herbal medicines, the medicine does not have any side effect on the body of primates after being taken, does not have any damage on the body and is low in cost.