38results about How to "Efficient treatment effect" patented technology

The invention provides an elastic membrane, and a preparation method and application thereof. The elastic membrane comprises a silicone rubber and a medicine. The medicine is coated inside the silicone rubber in a mode of a medicine storage area, and the medicine comprises estrogen. The elastic membrane achieves an efficient therapeutic effect through micro-release of the medicine, and the medicine release is more stable. The elastic membrane has a longer medicine release cycle and better slow release capacity and is used for treatment of uterine cavity damage in a medicine slow-release system. The method for preparing the elastic membrane is simple, raw materials are easy to obtain, the price is low, and industrial large-scale production application is facilitated.

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

The present invention provides a pharmaceutical composition containing sunitinib and its formulation and application, on the basis of the original sunitinib, further adding at least one tyrosine kinase receptor inhibitor, especially apatinib Nib and / or Axitinib can produce a very significant synergistic effect with it, thereby significantly inhibiting the proliferation of cancer cells, and has a very significant killing efficiency on cancer cells. The pharmaceutical composition provided by the present invention can obviously improve the problem of severe drug resistance caused by the simple use of sunitinib in the prior art and the problem of significantly reduced therapeutic effect when reducing the conventional dosage of sunitinib, greatly It improves the efficiency of clinical treatment, reduces the side effects of treatment for patients, provides a new solution for clinical treatment, and has a very broad market prospect and extremely important social significance.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

A method for preparing ultra-high drug-loaded nanoparticles by means of sequence precipitation-complex coacervation. The method comprises: first, mix a first reactant and a second reactant in a first reaction vessel (1), and then precipitate active pharmaceutical ingredients in the first reaction vessel (1) to form cores of drug nanoparticles; the reaction product in the first reaction vessel (1) quickly flows into a second reaction vessel (2) to mix with a third reactant; and after undergoing a complex coacervation reaction, shell materials are deposited on the surfaces of the cores of drug nanoparticles so as to form ultra-high drug-loaded nanoparticles having a core-shell structure.

The invention provides an amphiphilic graft copolymer based on hyaluronic acid, its preparation method and application. The copolymer of the present invention includes: hyaluronic acid (HA) as a matrix, deoxycholic acid (DCA) grafted on the backbone, methoxypolyethylene glycol (mPEG) units and N-acetyl-L-half Cystine (NAC) group. The invention also provides a preparation method of the copolymer, wherein the copolymer is prepared by modifying HA with mPEG, DCA and NAC. The invention also provides a hemostatic sponge, a drug carrier and a drug composition prepared from the copolymer. The copolymer of the present invention has good biocompatibility, fast water absorption, active and passive dual targeting and redox conversion, so it can be used to prepare fast water-absorbing hemostatic sponge and anti-cancer drug release carrier, and realize prolonged blood circulation, high intake and Rapid drug release can effectively increase the drug concentration in tumor cells, and has broad application prospects.

The invention discloses composite nano-particles used in inorganic photodynamic therapy, and a preparation method thereof. According to the invention, nano-particles with an up-conversion luminescence property under infrared light excitation are composed with TiO2, ZrO2 or Zr-Ti-O nano-particles with good biocompatibility with cell killing property under ultraviolet light irradiation, such that composite nano-particles are prepared. The composite nano-particles can be adopted as a near-infrared-light-excited novel inorganic photodynamic therapy reagent, and has characteristics of good body tissue penetration capacity, good safety, and no damage. Because the particles have nano-grade dimensions, the retention time of the nano-particles in bodies is long, and the nano-particles have stability better than that of traditional organic photo-sensitizers. Therefore, the nano-particles have important application potential in photodynamic therapies of malignant tumors.

A preparation for treating periodontitis with a combination prescription of Coptidis Rhizoma and Rhizoma Drynariae effective parts, the raw material components include: 10-15 parts of water extract of Coptidis Rhizoma effective parts containing more than 80% berberine; naringin 30.71 % more than 5-10 parts of drynaria effective parts water extract; made into "Lian Bu Gu Chi Capsule" for systemic administration; or adding hydroxyethyl cellulose, concentrated glycerin, polyacrylic resin and other auxiliary materials to make a The new long-acting compound ointment of traditional Chinese medicine for external use "Lian Bu Gu Te Ointment" is easy to operate in the periodontal pocket by means of syringe administration. The invention has good therapeutic effect on periodontitis. The invention has the characteristics of small prescription, remarkable curative effect and no toxic and side effects. Especially when applied locally, the anti-inflammatory effect of long-term use is similar to that of minocycline hydrochloride ointment (Paileo), but the bone formation effect is obviously better than Paleo. New dosage forms of oral Chinese patent medicines with ease of use.

Disclosed are: a method for producing a cell mass containing a cytokine-induced killer (CIK) cell, which is characterized by comprising the step of culturing a cell mass containing a cell that can be differentiated into a CIK cell in the presence of a fragment of a fibronectin; and others.

The invention discloses a polyamino acid sound sensitizer as well as its preparation method and application. The main chain structure of the polyamino acid sonosensitizer of the present invention is aspartic acid grafted with protoporphyrin, which has good biocompatibility, and the side bond of protoporphyrin modified on the water-soluble polyaspartic acid greatly improves The solubility of protoporphyrin is improved, the blood compatibility of the sonosensitizer in the body and the accumulation amount of the lesion are increased, so as to produce a better therapeutic effect and realize efficient and safe tumor treatment. The present invention also provides a sound sensitizer nanovesicle and its target-modified sound sensitizer nanovesicle, which has the effect of high efficiency and low toxicity, and provides a new type of sound sensitizer with excellent performance for the development of safe and efficient sonodynamic therapy. Sensitizer materials, and by modifying specific antibodies or ligands on their surface, improve their aggregation at the target site.