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A kind of Pudilan children's antiviral oral pellet gel and preparation method thereof

A pellet gel, antiviral technology, applied in the field of medicine, to achieve antiviral and antibacterial effects, high-efficiency treatment effects, and easy digestion effects

Active Publication Date: 2019-08-06
黑龙江童医生儿童生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem of combining the pellets and gel proposed by the present invention to make Pudilan children's antiviral oral pellet gel composite dosage form has not been reported yet.

Method used

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  • A kind of Pudilan children's antiviral oral pellet gel and preparation method thereof
  • A kind of Pudilan children's antiviral oral pellet gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Pudilan children's antiviral oral pellet gel (jelly type)

[0037]Chinese medicine extract dry powder 30g, crystalline cellulose 40g, starch slurry 35g, acrylic resin 20g, calcium chloride 1.3g, sucrose 360g, orange essence 0.7g, sorbic acid 3.6g, carrageenan 4g, konjac powder 6g.

[0038] Add 75g of dandelion, 18g of kudiding, and 25g of Radix Radix to decoct twice, combine and concentrate, add ethanol to 70% precipitation, filter, recover ethanol to obtain concentrated solution I; add 30g of Scutellaria baicalensis to decoct twice, combine and concentrate, add ethanol to 50% % precipitate, filter, recover ethanol, add hydrochloric acid to adjust the pH value to 1.5, and obtain the concentrated solution of baicalin; add the concentrated solution of baicalin to the concentrated solution I, stir evenly, and obtain the concentrated solution of the Chinese medicine extract. The concentrated solution is spray-dried to make dry powder.

[0039] Mix the dry powd...

Embodiment 2

[0041] Embodiment 2 Pudilan children's antiviral oral pellet gel (jelly type)

[0042] Chinese medicine extract dry powder 35g, lactose 30g, starch slurry 30g, ethyl cellulose 15g, carrageenan 7g, agar 2g, konjac powder 1g, strawberry essence 0.9g, xylitol 450g, propyl paraben 4g, calcium chloride 1.5g

[0043] Add 75g of Dandelion, 20g of Kudiding, and 25g of Radix Radix Radix to decoct twice, combine and concentrate, add ethanol to 70% precipitation, filter, recover ethanol to obtain concentrated solution I; add 30g of Scutellaria baicalensis to decoct twice, combine and concentrate, add ethanol to 50% % precipitate, filter, recover ethanol, add hydrochloric acid to adjust the pH value to 1.5, and obtain the concentrated solution of baicalin; add the concentrated solution of baicalin to the concentrated solution I, stir evenly, and obtain the concentrated solution of the Chinese medicine extract. The concentrated solution is spray-dried to make dry powder.

[0044] Mix the...

Embodiment 3

[0046] Example 3 Pudilan children's antiviral oral pellet xerogel (solid particle type)

[0047] Chinese medicine extract dry powder 40g, starch 28g, starch slurry 50g, hydroxypropyl methylcellulose 12g, calcium chloride 1.5g, carrageenan 4g, xanthan gum 2g, konjac powder 2g, pineapple essence 1.0g, ethyl paraben Ester 4g, Glucose 500g

[0048] Add 80g of Dandelion, 20g of Kudiding, and 30g of Radix Radix Radix to decoct twice, combine and concentrate, add ethanol to 70% precipitation, filter, recover ethanol to obtain concentrated solution I; add 30g of Scutellaria baicalensis to decoct twice, combine and concentrate, add ethanol to 50% % precipitate, filter, recover ethanol, add hydrochloric acid to adjust the pH value to 1.5, and obtain the concentrated solution of baicalin; add the concentrated solution of baicalin to the concentrated solution I, stir evenly, and obtain the concentrated solution of the Chinese medicine extract. The concentrated solution is spray-dried to ...

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Abstract

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to Pudilan antiviral oral pellet gel for children and a preparation method thereof. Background technique [0002] Dandelion contains sterols, caffeic acid, chlorogenic acid, etc., which have the effects of clearing heat and detoxification, eliminating carbuncles and resolving stagnation; Kudiding contains various alkaloids, coumarin lactones, steroidal saponins, volatile oil, etc. It has the effects of clearing heat and detoxifying, promoting blood circulation and reducing swelling; Radix Radix isatidis contains indirubin, β-sitosterol, adenosine, palmitic acid, various amino acids, etc., which has the effects of clearing heat and detoxifying, cooling blood and relieving throat; Scutellaria baicalensis contains baicalin and baicalein , wogonoside, volatile oil, etc., have the effects of clearing heat and dampness, purging fire and detoxification, hemostasis, and anti-ab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/66A61P31/12
Inventor 刘晓磊姜波王娜彭项雨
Owner 黑龙江童医生儿童生物制药有限公司
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