89results about "Vibration crystallization" patented technology

This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.

A device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a solution of such compound to be crystallized with at least one stream of an anti-solvent and passing the mixed streams at an elevated pressure through a local constriction of flow to create hydrodynamic cavitation thereby causing nucleation and the direct production of crystals.

A device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a solution of such compound to be crystallized with at least one stream of an anti-solvent and passing the mixed streams at an elevated pressure through a local constriction of flow to create hydrodynamic cavitation thereby causing nucleation and the direct production of crystals. The compound to be crystallized can be, for example, an active pharmaceutical ingredient.

A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

This invention provides an oscillating baffled reactor apparatus for preparing crystalline particles of at least one substance comprising: a reactor vessel; means for supplying a first flowing stream; means for oscillating fluid within the reactor vessel; a plurality of baffles; source of ultrasonic radiation; and means for collecting said particles.

It is an object of the present invention to provide a method for producing microparticles, which can produce monodispersed microparticles, causes no clogging with a product due to self-dischargeability, requires no great pressure, and is excellent in productivity, wherein a fluid in which at least one kind of microparticle materials is dissolved is introduced between two processing surfaces arranged to be opposite to each other to be able to approach to and separate from each other, at least one of which rotates relative to the other, to be formed into a thin film fluid, and the thin film fluid is cooled or heated (warmed) to allow saturation solubility to change, thereby separating microparticles.

There is provided a process for producing fine particles of an organic compound by a continuous-type poor solvent precipitation method which is capable of rapidly and uniformly dispersing an organic compound-containing solution in a large amount of a poor solvent, thereby more readily producing fine particles of the organic compound having a volume-average particle size of not more than 1 μm. In the process for producing fine particles of an organic compound, the poor solvent in which the organic compound is hardly soluble, is continuously mixed with the organic compound-containing solution prepared by dissolving the organic compound in a good solvent which is miscible with the poor solvent and in which the organic compound is readily soluble, while irradiating an ultrasonic wave thereto.

A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.

The present invention provided the manufacturing method of an organic compound particulate which utilizes a poor solvent depositing method of a continuous system and can quickly and uniformly disperse an organic compound solution in quantities of a poor solvent and which can more easily manufacture the organic compound particulate of <=1 [mu]m volume average grain size. In the manufacturing method of the organic compound particulate, an organic compound solution obtained by dissolving the organic compound in a good solvent which is miscible with the poor solvent and easily dissolves the organic compound is continuously mixed with the poor solvent which hardly dissolves the organic compound to manufacture the organic compound particulate. The organic compound solution is mixed with the poor solvent under ultrasonic irradiation.

The invention relates to a crystallization tank for traditional Chinese medicine extraction. The crystallization tank comprises a crystallization tank body and a crystal seed generation tank, wherein a tank cover is arranged on the crystallization tank body; a plurality of material addition ports are formed in the tank cover; a motor is arranged above the crystallization tank body and connected with a stirring shaft; a plurality of paddles are arranged on the stirring shaft; a first cooling jacket is arranged around the crystallization tank body; a discharge port is formed in the bottom of the crystallization tank body; a second cooling jacket is arranged around the crystal seed generation tank; a plurality of ultrasonic transducers are uniformly arranged on the outer wall of the second cooling jacket; a feeding port and a conveying port are formed in the top and the bottom of the crystal seed generation tank respectively; the conveying port is connected with a conveying pipeline, and the other end of the conveying pipeline extends into the upper part of the crystallization tank body. With the adoption of the crystallization tank for traditional Chinese medicine extraction, the quantity of added crystal seeds and the granularity can be effectively controlled, the controllability of the crystallization process is improved, the quality of produced traditional Chinese medicine crystals is good, the purity is high, the granularity is uniform, and convenience is brought for the following preparation process.

The invention discloses a method for preparing electronic-grade nickel sulfate from nickel powder, a crystallization device and a control method of the crystallization device, and relates to the technical field of non-ferrous metal hydrometallurgy. The method comprises the steps of oxidation, cooling, acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and screening, and secondary leaching, and is characterized in that in the oxidation step, the temperature of nickel powder in a calcining furnace is controlled to be 400-700 DEG C, the use amount of compressed air for each kilogram of nickel powder is 1-5 m3, and the reaction is carried out for 1.0-2.5 hours; the acid leaching comprises the following steps: putting the cooled nickel oxide in a reactor, controlling the temperature to be 45-70 DEG C, adding dilute sulfuric acid to control the pH value to be 0.5-1.5, and reacting for 1-3 hours. The invention also provides a crystallization device and a control method of the crystallization device. According to the method, metal nickel can be oxidized into divalent nickel oxide, hydrogen cannot be released when acid is added for dissolution, a large number of oxidizing agents do not need to be additionally added, new impurity ions are not added in the process, the nickel ion concentration is relatively improved, and nickel sulfate crystal particles are uniform.

A method and device for producing crystalline active ingredient particles. The active ingredient is crystallized from a supersaturated solution on the surface of particles of the active ingredient. A suspension of active ingredient particles is subjected to wet grinding in a supersaturated solution of the active ingredient in a first module. At least a part of the suspension is fed from the first module into the second module where it is cooled and simultaneously subjected to ultrasound. The suspension is fed back into the first module after cooling and being subjected to ultrasound. Active ingredient solution and optionally antisolvent are added to the suspension and active ingredient particles and liquid phase are extracted. A relative supersaturation of the active ingredient in the liquid phase of the suspension, relative to the entire liquid phase, is ≦90%, and the extracted active ingredient particles comprise a mean particle size of 10-500 μm.

A method of separating heavy water from normal through application of acoustic pressure shock waves to a fluid including heavy water and normal water and recovering separated normal water.

A process for preparing crystalline particles, especially particles of a pharmaceutical or carrier substance suitable for inhalation therapy, in addition to apparatus for the preparation of such particles.

The invention discloses a nitroguanidine crystal and a nitroguanidine microchannel crystallization process and device. After water, concentrated nitric acid and guanidine nitrate react, a nitroguanidine acid solution is obtained and is respectively fed into a microchannel crystallizer in a continuous mode for crystallization, ultrasonic treatment is carried out in the crystallization process, anda crystallized product is separated, washed and dried to obtain the high-purity spherical nitroguanidine crystal, wherein the mass fraction of nitroguanidine in the nitroguanidine acid solution is 25%-50%, the input flow rate of the nitroguanidine acid solution is 100-300 mL / min, the input flow rate of water is 150-400 mL / min, and the ultrasonic power of ultrasonic treatment is 1000-1800 W. The nitroguanidine microchannel crystallization process and the nitroguanidine microchannel crystallization device have the advantages of continuous operation, simple and controllable reaction conditions, high reaction safety and the like, and can be directly applied to actual production.

The invention discloses a vibration type atomized evaporative crystallization device. The vibration type atomized evaporative crystallization device comprises an atomized crystallization unit and a vibration unit, wherein the vibration unit comprise a rack, a motor and an eccentric gear which are located inside the rack; the motor is connected with the rack through a support; the motor is connected with the eccentric gear below the motor through a transmission shaft; the eccentric gear is arranged on a vibrating plate; the vibrating plate is connected with a torsion bar through a vibration bearing; a retainer of the vibration bearing is fixed on the rack; the other end of the torsion bar is connected with the atomized crystallization unit; an atomized crystallization chamber serves as the main body of the atomized crystallization unit; a hot air pipe and a high-speed centrifugal atomizer which is connected with a stock solution pipeline are respectively arranged at the top end of the atomized crystallization chamber; an air return pipeline is connected to the bottom end of the atomized crystallization chamber; a rectifier is arranged at the upper part of the atomized crystallization chamber. The vibration type atomized evaporative crystallization device, disclosed by the invention, has scale proofing and cleaning double functions, cancels the operation procedure that the conventional atomized evaporative crystallization device is required to be regularly shut down for scale cleaning, realizes continuous operation, and obviously improves the running efficiency of the device and the collecting yield of the crystallized product.

The invention discloses a salt-purifying system and method for synchronously removing organic matters through evaporation and crystallization of high-salt organic wastewater, belonging to the field of wastewater treatment. The purified salt-making system includes: an evaporation crystallizer; a material circulation pipe connected to the evaporation crystallizer; and the oxidation treatment reactor arranged on the material circulation pipe; and the ultrasonic vibrating device arranged at the lower side of the evaporation crystallizer. During the crystallization process, the present invention can effectively remove organic matter in the system and reduce the amount of hazardous waste disposal; the present invention has crystallization salt purification technology, which can effectively improve the concentration and purity of crystallization salt; the system of the present invention is highly integrated, compact in structure, and low in cost .

The present invention relates to a purification system configured such that a solution stored in a solution storage tank is dispersed / stirred ultrasonically and sent by an air compressor to a reactor in which the sent solution and a solvent introduced through another pathway are stirred to produce a reaction product, and a purification method using the purification system.

The invention relates to a crystallizer, in particular relates to a built-in ultrasonic stirring crystallizer. The built-in ultrasonic stirring crystallizer comprises a barrel body, wherein a hollow shaft is arranged in the position of a central axis of the barrel body; two ends of the hollow shaft penetrate through the barrel body; two sides of the hollow shaft are provided with multiple vibrator groups; multiple ultrasonic vibrators are arranged in the vibrator groups; one end of the hollow shaft is provided with an electric brush group; one end of the electric brush group is connected with the ultrasonic vibrators through wires, and the other end of the electric brush group is connected with an ultrasonic generator through a wire. According to the built-in ultrasonic stirring crystallizer disclosed by the invention, the built-in ultrasonic stirring crystallizer can be prevented from scaling to a certain degree, the unsaturation degree of a solution can be rapidly released by ultrasonic waves, uniform growth of crystals is promoted, materials are prevented from concentrating and crystallizing on a heat exchange interface, and dirt on the scaled heat exchange interface can be removed by the ultrasonic waves; the ultrasonic vibrators are enough close to the heat exchange interface, a using effect of removing the dirt is ensured, and the energy consumption is lower.

A method and system (10) for selectively removing one component of a material thereby concentrating other components of the material are disclosed. The material is cooled to below the melting temperature of the material to form a supercooled liquid phase with heat transfer plate with cooling channels (20). Ultrasonic energy from ultrasonic drivers (42) is applied to the material to form solid phase crystals of the component to be removed. These crystals are removed to leave the concentrated product. The ultrasonic energy prevents the growth of dendrites on the crystals, resulting in the formation and removal of small crystals of the component to be removed without damage to or removal of the remaining components. Methods and apparatuses for cryoprecipitation and chromatography are also disclosed.

This invention relates to a novel system for making uniform crystals. The system, by virtue of the nature of its crystal product, is useful in various chemical, pharmaceutical, agricultural, and biotechnology applications. The invention features physically separated and controlled crystal nucleation and growth zones useful in industrially scaled crystallization processes. The invention also provides a method to preferentially nucleate and crystallize a desired category of crystal structure (enantiomer, solvate, polymorph) of non-chiral and chiral compounds.

The invention discloses a crystallizer controlling crystal granularity through ultrasonic waves and a crystallization method. The crystallizer comprises a crystallization mother liquid container (4), an outer circulating pipe (5) is arranged outside the crystallization mother liquid container (4), a crystal blade pump (3) and a settling tank (6) are arranged on the outer circulating pipe (5), an ultrasonic generator (1) is arranged at the bottom of the settling tank (6), the settling tank (6) is provided with a bypass backflow pipe (7) in fluid communication with the same, an outlet end of the backflow pipe (7) is in fluid communication with the fluid of the outer circulating pipe 95), and a fine crystal eliminator (2) is arranged on the backflow pipe (7). The crystallizer effectively improves quality of crystal products; by grinding high-granularity crystals through the ultrasonic waves, the problem that the crystal products are high in granularity in the crystallization process can be solved while control on granularity and grain size distribution of the crystal products is realized, and product quality is improved.

A multi-stage submerged membrane distillation water treatment apparatus including: a plurality of raw water tanks arranged in multiple stages ranging from a first stage to an n-th stage and storing raw water, the raw water flowing sequentially from the first stage to the n-th stage; membrane distillation (MD) modules submerged in the respective raw water tanks and discharging a portion of the raw water as vapor; heat exchangers submerged in the respective raw water tanks and maintaining the raw water at a predetermined temperature by performing heat exchange between the raw water and vapor supplied from the respective previous-stage MD modules; a vapor generator generating and supplying high-temperature vapor to the first-stage heat exchanger; a condenser condensing vapor supplied by the n-th-stage MD module; and a raw water feeder feeding low-temperature raw water to the first-stage raw water tank via the condenser.

The invention relates to a continuous oscillatory flow membrane crystallization method of erythritol. The technical scheme is as follows: erythritol crystallization mother liquor is preheated and then sent into a hydrophobic hollow tubular membrane module; by arranging a circular baffle plate in the membrane module and producing oscillatory flow, fluid flowing and micromixing state on the surface of the membrane is remarkably improved, and the technical problem that concentration polarization is easy to happen in the membrane crystallization process or crystals on the membrane surface are easy to deposit and solvent out is effectively solved; water in the crystallization mother liquor entering the membrane module penetrates through the membrane in the form of water vapor and then is drawn out from the other side of the membrane by a vacuum pump and condensed into liquid water; the crystallization mother liquor which leaves the membrane module is concentrated to be saturated and then sent into a crystallizer; erythritol crystals undergo fluidization-suspension for growth; the upper layer of crystallization mother liquor in the crystallizer is pumped into the membrane module for internal circulation; and an erythritol crystallization product is led out of the lower part of the crystallizer. The method of the invention also has advantages as follows: continuous production is realized; and erythritol crystallization production cost can be effectively reduced.