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100 results about "Palate carcinoma" patented technology
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According to the American Cancer Society, 90 percent of all oral and oropharynx cancers are squamous cell carcinomas. (The palate is considered part of the oropharynx.) Squamous cell carcinomas are a type of cancer that affect the squamous cell, the top- and mid-level layers of skin and tissue.
Method for the diagnosis, prognosis and treatment of cancer metastasis
InactiveUS20170002357A1Peptide/protein ingredientsMicrobiological testing/measurementCancer preventionLymphatic Spread
This study describes a method to determine the likelihood of the development of metastasis in a subject suffering from cancer, in addition to a method to design a customized therapy in a subject suffering from cancer, in particular breast, colon, lung, kidney and thyroid cancer, based on the determination of the expression level of one or more genes whose expression is modulated by an increase in c-MAF expression. It also describes a method for the identification of marker genes with a propensity for metastatic cancer based on inducing the modulation of the c-MAF expression Finally, the use of PTHLH and PODXL inhibitors and RERG activators in the treatment and / or prevention of the cancer, in particular breast, colon, lung, kidney and thyroid cancer.
Owner:FUNDACIO INST DE RECERCA BIOMEDICA (IRB BARCELONA) +1
Method for detecting carcinomas in a solubilized cervical body sample
ActiveUS7306926B2Biological material analysisPeptide preparation methodsCervical intraepithelial neoplasiaMultiple Tumor Suppressor-1
Owner:VENTANA MEDICAL SYST INC
Application of microRNA in preparation of kit for diagnosis of cervical carcinoma or precancerous lesions
The invention relates to an application of microRNA in preparation of a kit for diagnosis of cervical carcinoma or precancerous lesions. According to the invention, obvious low expression of miR-375 and miR-424 in tissues and cells of cervical carcinoma or precancerous lesions is revealed, and the low expression is obviously relative to the cervical carcinoma or precancerous lesions. The invention also provides a cervical carcinoma or precancerous lesions diagnosis method and the kit for determining existence amount of miR-375 and / or miR-424.
Owner:HANGZHOU DALTON BIOSCI
Chinese medicinal formula for treating atrophic gastritis and precancerous lesion
InactiveCN101954048ALow recurrence rateRecently goodDigestive systemAntineoplastic agentsMedicinal herbsBarbed Skullcap Herb
The invention discloses a Chinese medicinal formula for treating atrophic gastritis and precancerous lesion. The effective ingredients comprise the following Chinese medicinal herbs by weight: 10 to 50 grams of sauted pilose asiabell root, 10 to 50 grams of sauted large-headed atractylodes rhizome, 10 to 30 grams of tuckahoe, 5 to 20 grams of pinellia tuber, 5 to 20 grams of dried orange peel, 3 to 10 grams of raw licorice root, 5 to 15 grams of root powder of pseudo-ginseng, 5 to 20 grams of zedoary, 5 to 20 grams of Zhejiang fritillaria bulb, 15 to 60 grams of spreading hedyotis herb, 10 to 60 grams of hairy-vein agrimonia herb and bud, 10 to 60 grams of barbed skullcap herb, 5 to 20 grams of fruit of princesplume ladysthumb and 5 to 20 grams of creeping fig fruit. The Chinese medicinal formula has the effects of tonifying spleen, regulating qi, dissipating blood stasis and detoxifying, treats both principal and secondary aspects of diseases aiming at the pathogenesis of the chronic atrophic gastritis and precancerous lesion, has low recurrence rate after healing and good short-term and long-term curative effect, and has not toxic or side effect.
Owner:胡一莉
Kit for morbidity-related tumor suppressor gene epigenetic mutation detection of gastrointestinal neoplasms and application thereof
The invention relates to a kit for morbidity-related tumor suppressor gene epigenetic mutation detection of gastrointestinal neoplasms and application thereof. The kit mainly comprises 25 pairs of gastrointestinal neoplasm morbidity-related tumor suppressor gene promotor region CpG-island amplification and sequencing primers of 9 kinds and a polymerase chain reaction (PCR) amplification reagent. Through a PCR amplification product obtained through the kit, a gene CpG-island methylation state can be analyzed through the methods of methylation specific PCR (MSP), combined bisulphite-restrictionanalysis (COBRA) or bisulfite sequencing PCR (BSP) and the like. The kit has the efficient effect of detecting CpG-island methylation and is used for the morbidity-related tumor suppressor gene epigenetic mutation detection of the gastrointestinal neoplasms.
Owner:NANJING UNIV
Post-treatment breast cancer prognosis
InactiveUS20130281502A1Accurate assessmentBiocideMicrobiological testing/measurementInitial treatmentCancer metastasis
The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat a patient. The levels of gene expression are disclosed as a molecular index for predicting clinical outcome, and so prognosis, for the patient. The disclosure further includes methods for predicting cancer recurrence, and / or predicting occurrence of metastatic cancer, after initial treatment with an anti-estrogen agent. The disclosure further includes methods for determining or selecting the treatment of a subject based upon the likelihood of life expectancy, cancer recurrence, and / or cancer metastasis.
Owner:THE GENERAL HOSPITAL CORP +1
Application of cancer suppressor gene FBXW7 in preparation of drugs used for preventing or treating breast tumors, expression vector and diagnosis medicine
ActiveCN103191443ARealize detectionGenetic material ingredientsMicrobiological testing/measurementIndividualized treatmentPrognostic prediction
The invention discloses application of a cancer suppressor gene FBXW7 in preparation of drugs used for preventing or treating breast tumors, an expression vector and a diagnosis medicine, belonging to the field of medical biotechnology. Specifically, the invention provides application of the cancer suppressor gene FBXW7 in preparation of drugs used for preventing or treating breast tumors, the expression vector constructed from the gene FBXW7 and a vector pcDNA3.1 and a preparation method thereof, and the breast tumor diagnosis medicine at least including a pair of primers capable of specific amplification of the gene FBXW7 and composed of an upstream primer and a downstream primer. Expression of the cancer suppressor gene FBXW7 is closely related to breast cancer molecular subtyping; the cancer suppressor gene FBXW7 has specific low expression in a breast cancer with high grade malignancy and exerts an inhibitory effect on growth of breast cancer cells. Thus, screening of breast cancers with low expression of the gene has significant meaning to prognostic prediction of the breast cancers; and specific recovery of expression of the cancer suppressor gene in breast cancer cells provides a novel approach for targeted individualized treatment of the breast cancers.
Owner:SHANDONG UNIV
Application of METRNL protein as colon cancer diagnostic marker and kit
The invention provides application of METRNL protein as a protein molecule marker for detecting colon cancer and application of the METRNL protein in preparing a colon cancer diagnostic reagent or a kit. Immunohistochemistry is carried out on 30 pairs of human colon cancer tissues and para-carcinoma tissues through immunohistochemistry tests, and the result proves that the METRNL protein has differential expression in cancer tissues and para-carcinoma tissues of the human colon cancer. Therefore, whether a patient has the colon cancer can be detected according to the expression quantity of the METRNL protein in colon tissues.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Composition for treatment and diagnosis of pancreatic cancer
InactiveUS20140010756A1Inhibit growthInhibiting metastasisIn-vivo radioactive preparationsPeptide/protein ingredientsCytotoxicityOncology
This invention relates to a pharmaceutical composition for inhibiting the growth and / or metastasis of invasive pancreatic cancer in a subject, comprising a molecular-targeted anticancer agent and a pharmaceutically acceptable carrier, wherein the molecular-targeted anticancer agent is a conjugate of a toxin or cytotoxic agent and an antibody or fragment thereof which immunologically and specifically binds to a cell-surface folate receptor β (FRβ) protein of an FRβ (+) macrophage that exists around pancreatic cancer cells at the invasive front, and to a diagnostic agent and kit for determining the degree of malignancy of pancreatic cancer or the presence of invasive pancreatic cancer, characterized by determining that the cancer tissue is invasive and metastatic when FRβ (+) macrophage is distributed around pancreatic cancer cells at the invasive front.
Owner:KAGOSHIMA UNIV
System used for predicting prognosis of liver cancer patient
ActiveCN107657149AAccurately predict clinical prognosisImproving the level of prognosis predictionHealth-index calculationMedical automated diagnosisData treatmentBiology
The invention discloses a system used for predicting prognosis of a liver cancer patient. The system comprises a system for detecting expression quantities of four proteins c-Met, Caspase8, CXCR4 andP-P21, and a protein expression quantity data processing system. The system for detecting the expression quantities of the four proteins measures the expression quantities of the proteins through an immunohistochemistry staining method; and the protein expression quantity data processing system converts the expression quantities of the four proteins in a para-carcinoma tissue of the to-be-predicted liver cancer patient into prognosis score values, and predicts the prognosis of the liver cancer patient according to the prognosis score values.
Owner:BIOMEDICAL ANALYSIS CENT OF ACADEMY OF MILITARY MEDICAL SCI
LncRNA molecule ENST00000438553 and application thereof in auxiliary diagnosis of nasopharyngeal carcinoma
ActiveCN105936904AHelps further elucidate the mechanism of developmentElucidate the mechanism of developmentMicrobiological testing/measurementDNA/RNA fragmentationMedicineNasopharyngeal carcinoma
The invention discloses an lncRNA molecule ENST00000438553 and application thereof in auxiliary diagnosis of nasopharyngeal carcinoma. The nucleotide sequence of ENST00000438553 is shown as SEQ ID NO.1. The expression quantity of TCONS_00003617 in nasopharyngeal carcinoma tissues is significantly higher than that of pericarcinomatous tissues. The lncRNA molecule ENST00000438553 can be used as a nasopharyngeal carcinoma molecular marker or target in early clinical diagnosis, prognosis or targeted therapy of nasopharyngeal carcinoma, and is beneficial to further explication of the occurrence and development mechanism, signal pathway and the like of nasopharyngeal carcinoma, thus having remarkable application prospect and theoretical value.
Owner:THE FIRST PEOPLES HOSPITAL OF FOSHAN
Method for establishing pancreatic cancer model
ActiveCN105132463AHigh simulationEfficient methodGenetic engineeringFermentationWilms' tumorTumor suppressor gene
The invention relates to a method for establishing a pancreatic cancer model, and belongs to the technical field of the establishment of an animal model. According to the method, a slow virus for over-expressing one cancer gene and simultaneous knocking down two cancer suppressor genes is constructed according to cancer genes and cancer suppressor genes having the maximum mutation rate in human pancreatic cancer in TCGA database, and the slow virus is applied to the pancreas head of a tree shrew through orthotopic injection so as to induce pancreatic cancer of the tree shrew; and specifically, the method comprises the following steps: (1) construction of a slow virus vector; (2) virus packaging, titre determination and in vitro verification; (3) virus injection; and (4) monitoring and pathological investigation of the tree shrew. The method disclosed by the invention has the advantages that the method is short in inducing cycle, high and stable in morbidity, and simple and convenient in operation, and is capable of rapidly and effectively establishing a tree shrew pancreatic cancer model for simulating the genetic mechanism of human pancreatic cancer to the greatest extent; and the pancreatic cancer model is applicable to the research of the pathogenesis of human pancreatic cancer, the exploration of cancer therapy targets and the development of novel antineoplastic drugs, so as to offer a reference for the treatment of human pancreatic cancer.
Owner:成都豆麦科技有限公司
Cancer compound 10-hydroxycamptothecine and crizotinib for treating lung cancer and application
InactiveCN109091480AGood curative effectLittle side effectsOrganic active ingredientsAntineoplastic agentsSide effectWilms' tumor
Owner:TIANJIN UNIV OF SCI & TECH
LncRNA related to colorectal cancer and application thereof
The invention discloses an lncRNA related to colorectal cancer and application thereof. An inventor conducts transcriptome lncRNA-mRNA sequencing analysis on cancer tissue and para-carcinoma tissue ofpatients suffering from the colorectal cancer, 1ncRNAs obvious in differential expression and co-expression genes thereof are sought, and LOC105374879 closely related to the colorectal cancer and co-expression genes of the LOC105374879 are found. Accordingly, a new molecular marker is provided for the early diagnosis of the colorectal cancer, and a foundation is laid for clinical application.
Owner:TIANJIN CITY THIRD CENT HOSPITAL
Method for Treating Cancer Harboring a p53 Mutation
InactiveUS20130281493A1Preventing or delaying the onset (or reoccurrence)Reduce the possibilityBiocideOrganic chemistryCancer cellFhit gene
A method for determining if a subject with cancer or precancerous lesions or a benign tumor, will respond to treatment with an inhibitor selected from the group comprising an inhibitor of one or more enzymes in the mevalonate pathway, an inhibitor of geranylgeranyl transferase, an inhibitor of farnesyl transferase or an inhibitor of squalene synthase, by (i) obtaining a sample of the cancer cells, precancerous cells or benign tumor cells from the subject, (ii) assaying the cells in the sample for the presence of a mutated p53 gene or a mutant form of p53 protein or a biologically active fragment thereof, and (iii) if the cells have the mutated p53 gene or mutant form of the p53 protein, then determining that the subject will respond to treatment with the inhibitor or combinations thereof. Some embodiments are directed to treatment with the inhibitors.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Tumour Vaccine Comprising Allogenic or Xenogeneic Tumour Cells
ActiveUS20100055136A1Increase awarenessSmall sizeBiocideMammal material medical ingredientsImmunologic functionWilms' tumor
Owner:STATHOPOULOS APOSTOLOS
Biomarker for early breast cancer diagnosis
InactiveCN109628600AMicrobiological testing/measurementAntineoplastic agentsEarly breast cancerTissue sample
The invention discloses a biomarker for early breast cancer diagnosis. The biomarker is LINC01929. By the detection of tissue samples and paracancerous tissues of breast cancer in stage I-II, it is found that the expression level of LINC01929 in cancer tissues is significantly up-regulated, suggesting that LINC01929 can be used for the diagnosis and treatment of early breast cancer.
Owner:赣南医学院第一附属医院
Application of dendrophenol in preparing medicines for inhibiting proliferation of cervical carcinoma cells and for inducing autophagic apoptosis of cervical carcinoma cells
InactiveCN105943523APrevent proliferationInduced cycle arrestEther/acetal active ingredientsAntineoplastic agentsCervical tumorMedicine
The invention discloses an application of dendrophenol in preparing medicines for inhibiting proliferation of cervical carcinoma cells and for inducing autophagic apoptosis of cervical carcinoma cells, and belongs to the field of medicines. By inhibiting the proliferation of the cervical carcinoma cells and inducing the autophagic apoptosis activity of the cervical carcinoma cells in vitro, an anti-tumor effect of the dendrophenol in resisting the cervical carcinoma cells is detected, and an anti-tumor concentration of the dendrophenol is analyzed, proving that the dendrophenol has an obvious inhibitory effect on the cervical carcinoma cells; therefore, novel medicines for treating human cervical carcinoma can be developed conveniently. The human cervical carcinoma cells are Hela cells. The effective concentration range of the dendrophenol of inhibiting the proliferation of the cervical carcinoma cells and inducing the autophagic apoptosis of the cervical carcinoma cells is 25-200 [mu]mol / L.
Owner:HEFEI NORMAL UNIV
Development of universal cancer drugs and vaccines
ActiveUS9394538B2Reduce the number of copiesStrong specificitySugar derivativesMicrobiological testing/measurementLymphatic SpreadEmbryo
Owner:LIN SHI LUNG +1
Hepatocellular carcinoma marker
ActiveCN106662588AReduce functionPreparing sample for investigationBiological material analysisEpitopeHigh mannose
Owner:NAT INST OF ADVANCED IND SCI & TECH
Berberine-containing pharmaceutical composition for inhibiting cancer stem cell growth or carcinoma metastasis and application thereof
InactiveUS20120321726A1Inhibit cell growthReduced viabilityBiocideOrganic chemistryBerberineCancer research
Owner:NATIONAL TAIWAN NORMAL UNIVERSITY +1
Method for detecting precancerous lesions
ActiveUS20160153050A1Efficient detectionMicrobiological testing/measurementLibrary screeningBiomarker (petroleum)Phases of clinical research
The present invention relates to the novel use of syndecan-2 (SDC2) gene as a CpG methylation biomarker for detecting precancerous lesions, and more particularly, to the use of the SDC2 gene as a biomarker to early diagnose colorectal precancerous lesions by measuring the degree of methylation of the SDC2 gene. The present invention provides a method of providing information for diagnosis of precancerous lesions by detecting methylation of the CpG islands of the SDC2 gene. In addition, the use of the methylation detection and kit according to the present invention makes it possible to diagnose colorectal precancerous lesions at an early transformation stage, thus enabling the early diagnosis of colorectal precancerous lesions. Furthermore, the methylation detection method and kit of the present invention enables colorectal precancerous lesions to be effectively diagnosed in an accurate and rapid manner compared to conventional methods.
Owner:GENOMICTREE
MicroRNA markers for discriminating constitutional lung cancer tissue and paracancerous tissue
InactiveCN102851282AMicrobiological testing/measurementVector-based foreign material introductionMicroRNABiology
The invention relates to microRNA makers for discriminating constitutional lung cancer tissue and paracancerous tissue. More specifically, the invention relates to 38 microRNA markers for discriminating constitutional lung cancer tissue and paracancerous tissue. It has been proved by examination that, these specific microRNA markers can effectively discriminate constitutional lung cancer tissue and paracancerous tissue. The invention also relates to a chip and a test kit for detecting the microRNA markers.
Owner:SHANGHAI INST OF ONCOLOGY
Method for establishing pancreatic cancer model in wild-type adult mouse through lentiviruses
The invention discloses a method for establishing a pancreatic cancer model in a wild-type adult mouse through lentiviruses. The method comprises lentiviral vector construction, virus packaging, titerdetermination and in-vitro verification, virus injection, and pathological identification. The method comprises selecting an oncogene Kras with the highest variation rate of the human pancreatic cancer and cancer suppressor genes of Tp53, Cdkn2a and Cdkn2b, overexpressing the oncogene KrasG12D in the same lentiviral vectors, simultaneously, knocking down Tp53, Cdkn2a and Cdkn2b through shRNA, carrying out virus injection, and after 40 days, detecting significant pancreatic tumors in the adult mouse which is killed by the pancreatic cancer. The method has a short induction period and high andstable incidence, is easy to operate and fast builds the adult mouse pancreatic cancer model. The pancreatic cancer model simulates the genetic mechanism of human pancreatic cancer to the maximum extent, can be used to study the pathogenesis of human pancreatic cancer and the screening of new therapeutic drugs and therapeutic target points and provides a reference for the treatment on human pancreatic cancer.
Owner:成都豆麦科技有限公司
Application of melittin in preparation of drug used for inhibiting invasion metastasis of breast cancer cells
InactiveCN104784677ATransfer barrierPeptide/protein ingredientsAntineoplastic agentsLymphatic SpreadCancer cell
The invention specifically relates to application of melittin in preparation of a drug used for inhibiting invasion metastasis of breast cancer cells, which belongs to the field of bioengineering technology. CD147 and MMP9 proteins exert significant effects on invasion and metastasis of breast cancer MCF-7 cells. The invention aims to find a CD147 expression inhibitor which is capable of hindering or reducing secretion of MMP9 and inhibiting invasion metastasis of cancer cells to cancerous peripheral tissue. According to the invention, MCF-7 cells are cultured at first, then different doses of melittin is used, and flow cytometry, ELISA and RT-PCR experimental results prove that expression of CD147 and MMP9 is suppressed in the MCF-7 cells treated by melittin; and then Transwell invasion chamber experiments are conducted to detect the migration rate of the MCF-7 cells treated by melittin. Melittin can inhibit invasion metastasis of the MCF-7 cells. Thus, a novel anti-breast cancer drug can be developed from melittin.
Owner:NORTHEAST NORMAL UNIVERSITY
Methods for Detection, Staging, and Surveillance of Colorectal Adenomas and Carcinomas
Owner:WISCONSIN ALUMNI RES FOUND
Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for cancer stem cells cancer
PendingCN105339390AImmunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsBiomarker (petroleum)Diagnostic strategy
Owner:OGD2 PHARMA +1
A method of targeting patient-specific oncogenes in extrachromosomal DNA to treat glioblastoma
PendingUS20190360029A1Inhibits tumor glioma growthCompounds screening/testingMicrobiological testing/measurementBAP1Present method
Provided are methods of targeting patient-specific oncogenes in extrachromosomal DNA (ecDNA) to treat glioma in a human. The present methods include identifying a drug that targets against an oncogene present in ecDNA of a human suffering from glioma, such as glioblastoma. The identified oncogenes present in ecDNA include MET, MET / CAPZA2, MDM2, CDK4, SOX2, PIK3CA, MECOM, PDGFRA, EGFR, MYCN, MYC, TERT, SMARCA4, RP56, FBXW7, CDK6, CCND2, ERBB2, BRCA1, and BAP1. The present methods include identifying a drug targeted against the ecDNA oncogene, which drug inhibits the function of the identified oncogene, so as to inhibit tumor growth or progression of the glioma in the human. Also provided are PDX mouse models to further identify and / or confirm patient-specific drugs that target the identified oncogene(s) present in ecDNA. Also provided are methods of diagnosing gliomas or recurrent gliomas and methods of screening or monitoring for recurrence of gliomas. Further provided are methods of validating a predicted presence of ecDNA in a brain tumor using fluorescence in situ hybridization (FISH). Also provided are methods of screening drug candidates for a patient by implanting different identified drugs that target an identified oncogene into PDX mouse models.
Owner:HENRY FORD HEALTH SYST
Oral cancer detection marker and oral cancer detection kit
The invention belongs to the technical field of biology and particularly discloses an oral cancer detection marker and an oral cancer detection kit. The levels of mRNA of CDC6, CDT1, MCM2 and CDC45 in buccal mucosal cells of a normal person, a person with oral inflammation, a person with precancerous lesions, a person with oral cancer and a person at the postoperation period are quantitatively detected, the detection shows that CDC6, CDT1, MCM2 and CDC45 are ideal tumor markers for the screening of the oral cavity in the early stage, and the normal buccal mucosal cells and the canceration exfoliated cells are effectively distinguished. The oral cancer detection marker and the oral cancer detection kit are of great significance for the exploration of the mechanism of the content change of the tumor marker in the buccal mucosal cells and the clinical value of prognosis judgement.
Owner:SHENZHEN UNIV
Treatment of nut midline carcinoma
InactiveUS20180193350A1Good curative effectOrganic active ingredientsDisease diagnosisOncologyCarcinoma
Owner:TENSHA THERAPEUTICS
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