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Oral cancer detection marker and oral cancer detection kit

A technology of oral cancer and a kit, which is applied in the field of detection of oral cancer markers and kits, and can solve the problem of no report on DNA replication initiation protein

Active Publication Date: 2017-05-10
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the study of DNA replication initiation protein in oral exfoliated cells

Method used

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  • Oral cancer detection marker and oral cancer detection kit
  • Oral cancer detection marker and oral cancer detection kit
  • Oral cancer detection marker and oral cancer detection kit

Examples

Experimental program
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Embodiment 1

[0017] 1. Research objects: 76 cases of patients in the disease group and 24 cases of normal healthy people were used as the control group;

[0018] Diseased group: 76 patients were selected from the Department of Stomatology of the First Affiliated Hospital of Sun Yat-sen University School of Medicine from 2007 to 2008, including 14 cases of inflammation, 14 cases of precancerous lesions (white spots), 20 cases of oral cancer, and 28 cases of postoperative In all cases, the primary lesion was resected by surgery. The inflammation group was mostly periodontitis and floor cellulitis, the precancerous injury group was leukoplakia and oral benign tumors, and the oral cancers were mostly squamous cell carcinoma of the tongue, buccal carcinoma, and jaw bone. Cancer, gingival cancer, the clinical diagnosis of the patients was confirmed as oral squamous cell carcinoma by pathological diagnosis, and no other malignant tumors were found in the systemic examination. The age of the patien...

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PUM

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Abstract

The invention belongs to the technical field of biology and particularly discloses an oral cancer detection marker and an oral cancer detection kit. The levels of mRNA of CDC6, CDT1, MCM2 and CDC45 in buccal mucosal cells of a normal person, a person with oral inflammation, a person with precancerous lesions, a person with oral cancer and a person at the postoperation period are quantitatively detected, the detection shows that CDC6, CDT1, MCM2 and CDC45 are ideal tumor markers for the screening of the oral cavity in the early stage, and the normal buccal mucosal cells and the canceration exfoliated cells are effectively distinguished. The oral cancer detection marker and the oral cancer detection kit are of great significance for the exploration of the mechanism of the content change of the tumor marker in the buccal mucosal cells and the clinical value of prognosis judgement.

Description

technical field [0001] The invention relates to the field of biotechnology, and specifically discloses a marker for detecting oral cancer and a kit thereof. Background technique [0002] DNA replication initiation protein is currently recognized as a marker to characterize the state of cell proliferation, and has been widely used in various cancers such as cervical cancer, bladder cancer, and prostate cancer. Williams was the first to apply DNA replication initiation protein in the detection of exfoliated cells in urine. MCM5, CDC6, PCNA and Ki67 were detected in 92 cases of cervical cancer exfoliated cell smears and 57 tissue sections. The results of immunofluorescence experiments showed that, The differences in expression of these proteins at different pathological stages can be observed in malignant cells, among which MCM5 and CDC6 are more sensitive than PCNA and Ki67. It reflects that DNA replication initiation protein is more sensitive than traditional cell proliferat...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158
Inventor 李建娜陈思高开屏
Owner SHENZHEN UNIV
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