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System used for predicting prognosis of liver cancer patient

A technology for liver cancer and patients, applied in the field of biomedicine, can solve problems such as few

Active Publication Date: 2018-02-02
BIOMEDICAL ANALYSIS CENT OF ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, tumor research reports a large number of tumor markers, and various liver cancer markers emerge in endlessly, but few of them can be effectively used clinically.

Method used

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  • System used for predicting prognosis of liver cancer patient
  • System used for predicting prognosis of liver cancer patient
  • System used for predicting prognosis of liver cancer patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1. Discovery of liver cancer-related protein profile, combined molecular marker model, liver cancer prognosis judgment, P4-HCC prognosis liver cancer method and validation of its effectiveness

[0058] 1. Discovery of liver cancer-related protein profiles

[0059] 1.1. Cases and samples

[0060] Formalin-fixed and paraffin-embedded human liver tumor tissue and paired paracancerous tissue samples were provided by the Department of Pathology, Southwest Hospital of Chongqing. Providers (ie, patients) of liver tumor tissue and matched paracancerous tissue underwent liver cancer surgery at Chongqing Southwest Hospital between 2005 and 2008. The present invention does not include the following cases: cases with malignant tumors in the past, cases treated by other means such as chemoembolization for liver cancer before surgery, and those cases that died within 30 days after surgery. Patients who provided liver tumor tissue and matched paracancerous tissue gave inform...

Embodiment 2

[0118] Example 2. Further prognosis of BCLC-graded liver cancer patients by P4-HCC prognosis method for liver cancer

[0119]The method for further prognosis of liver cancer patients graded by BCLC is as follows: for liver cancer patients of any grade graded by BCLC (such as patients with stage O&A liver cancer), the expression score of P4-HCC is obtained according to the method of Example 1, and then the P4-HCC expression score is obtained. The expression score was obtained according to the method in step 2.1 of Example 1 to obtain a prognosis score; each prognosis score was determined according to the method in step 2.2 of Example 1 to determine whether the liver cancer patient had a good prognosis or a poor prognosis.

[0120] Using the P4-HCC prognosis liver cancer method, each patient in the liver cancer test group can be further divided into a poor prognosis group or a good prognosis group on the basis of BCLC grading (P figure 2 ). The results showed that the P4-HCC pro...

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Abstract

The invention discloses a system used for predicting prognosis of a liver cancer patient. The system comprises a system for detecting expression quantities of four proteins c-Met, Caspase8, CXCR4 andP-P21, and a protein expression quantity data processing system. The system for detecting the expression quantities of the four proteins measures the expression quantities of the proteins through an immunohistochemistry staining method; and the protein expression quantity data processing system converts the expression quantities of the four proteins in a para-carcinoma tissue of the to-be-predicted liver cancer patient into prognosis score values, and predicts the prognosis of the liver cancer patient according to the prognosis score values.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a system for predicting the prognosis of liver cancer patients. Background technique [0002] Liver cancer is the fifth most common cancer in the world, and the cancer-related death rate ranks third after lung cancer and gastric cancer. According to data released by the World Health Organization in 2011, about 700,000 people worldwide die of liver cancer every year. The incidence of liver cancer is on the rise in the world. The incidence of liver cancer in western countries is lower than that in developing countries, but the upward trend is also obvious (the incidence of liver cancer in the United States has doubled in the past 10 years). Therefore, in recent years, research on liver cancer in western countries has also received great attention. To sum up, liver cancer is a major disease that seriously threatens the health and life safety of the Chinese people and restricts s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18G16H50/30G16H50/20
CPCG16B20/00
Inventor 夏晴张学敏周涛宫琳
Owner BIOMEDICAL ANALYSIS CENT OF ACADEMY OF MILITARY MEDICAL SCI
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