40 results about "P-aminothiophenol" patented technology

The invention discloses a p-aminophenyl-beta-hydroxyethyl sulfide preparation method comprising the steps that: (1) under the effect of a catalyst, sodium sulfide, sodium hydrosulfide and nitro chlorobenzene are mixed, such that nucleophilic substitution reaction, and nitro reduction reaction are carried out; and post-treatment is carried out, such that sodium p-aminothiophenol is obtained; (2) sodium p-aminothiophenol is subjected to a reaction with ethylene oxide, such that p-aminophenyl-beta-hydroxyethyl sulfide is obtained. According to the invention, a mixed solution of sodium sulfide and sodium hydrosulfide is used for replacing a polysulfide solution for carrying out the substitution and reduction reactions, such that the nucleophilic reagent SH<-> has high concentration at the beginning, and the substitution reaction can be smoothly carried out, side reaction can be inhibited, and yield can be improved. Ethylene oxide is used for replacing 2-chloroethanol in a condensation reaction with sodium p-aminothiophenol, such that production process is reduced, and production cost is reduced.

The invention discloses a method for forming a SERS active substrate by assembling gold nanoparticles to an electrostatic spinning polymer nanofiber membrane and aims at building the active SERS substrate for sensitive detection. The method is based on the gold nanoparticles assembled by the electrostatic spinning polycarpolaction nanofiber membrane; the method comprises the following steps: firstly, inducing the crylic acid to perform grafting modification on the hydrophobic surface of the polycarpolaction nanofiber membrane by adopting the ultraviolet light, and then soaking the polycarpolaction nanofiber membrane in a gold nanoparticle solution for promoting the gold nanoparticles to be assembled to the polycarpolaction nanofiber so as to form the SERS active substrate; a p-aminothiophenol (4-ATP) molecule is adopted as an experiment probe molecule for SERS research, and the research shows that the substrate has the high SERS response sensitivity; the method has great advantages on environment-friendly synthesis, large scale, high stability and good repeatability; the highly active SERS substrate can be used for probing medicine molecules such as 2-thiouracil.

The invention discloses a method for rapid on-site detection of formaldehyde and acetaldehyde in wine. The present invention uses a paper-based microfluidic analysis device μ-PAD to extract formaldehyde and acetaldehyde in edible wine samples, uses p-aminothiophenol ATP as a probe molecule, and uses silver nanoparticles Ag NPs prepared by silver mirror reaction as a surface-enhanced puller. With the enhanced substrate of Mann scattering, the relationship between the peak intensity of p-aminothiophenol and the content of formaldehyde or acetaldehyde is established by a portable Raman spectrometer, so as to realize the on-site rapid quantitative and qualitative detection of formaldehyde and acetaldehyde in the wine sample to be tested. Compared with the existing on-site rapid detection method of formaldehyde and acetaldehyde, the present invention has the characteristics of high selectivity, rapid analysis, high sensitivity, less sample consumption, wide application range, simple operation and convenient portability. The detection limits of this method were 0.0046 μM for formaldehyde and 0.0032 μM for acetaldehyde.

The invention discloses a method for fast detecting nitrite in food through fluorescent / colorimetric double probes. The method comprises the following steps of (1) preparing a gold nanometer rod modified by p-aminothiophenol; (2) preparing gold nanometer spheres modified by 1,8-diaminonaphthalene; (3) proportionally mixing the two kinds of nanometer materials; adding the mixture into the same kind of food to be tested with different known nitrite concentrations; obtaining optical photos in a fluorescent lamp and an ultraviolet lamp; (4) dripping the two kinds of nanometer materials mixed in the step (3) into the food to be tested; performing analysis and detection at the same time by a colorimetric method and a fluorescent method. The field fast qualitative and quantitive analysis on the nitrite in the food can be realized through comparing the color in the fluorescent lamp and the ultraviolet lamp. The method has the characteristics that the use cost is low; the instrument equipment is simple; the analysis is fast; the sensitivity is high; the sample consumption is low; the application range is wide, and the like. The field fast detection on the nitrite in the food can be realized.