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SERS detection method employing nano semiconductor material as substrate

A nano-semiconductor, semiconductor technology, applied in the field of molecular recognition, can solve the problem of non-compliance of SERS intensity

Inactive Publication Date: 2009-06-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, many complex phenomena observed in experiments cannot be explained by the existing SERS theory
For example, for ordinary Raman spectroscopy, the intensity of the Raman signal is proportional to the fourth power of the excitation light frequency, but the SERS intensity does not follow this relationship; only a few substrates have the SERS effect, etc.

Method used

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  • SERS detection method employing nano semiconductor material as substrate
  • SERS detection method employing nano semiconductor material as substrate
  • SERS detection method employing nano semiconductor material as substrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Surface functionalization of CdTe quantum dots:

[0058] Dissolve 80 mg of sodium borohydride in 1 ml of deionized water, add 127.5 mg of tellurium powder, and cool with an ice-water bath. During the reaction, the system communicates with the outside world through a small pinhole in order to release the generated hydrogen. After about 8 hours, the black tellurium powder disappeared and white sodium borate crystals were produced. A clear NaHTe solution was thus obtained.

[0059] Thiol-stabilized CdTe nanocrystals via Cd 2+ And NaHTe reaction preparation. 100ml of 4-mercaptopyridine (4-MPY), mercaptoamine (2DMAET) and cadmium nitrate (Cd(NO 3 ) 2 ) The pH value of the mixed solution was adjusted to 5.0-6.0 with 0.1N NaOH, and stirred vigorously. During this process, N 2 Gas deoxygenation. Then quickly add the self-prepared NaHTe solution, and continue to stir for 10-30 minutes to obtain a CdTe precursor solution. Among them, Cd 2+ 、HTe - , 4-MPY, 2DMAET molar r...

Embodiment 2

[0069]Surface functionalization of CdS quantum dots:

[0070] Nitrogen was passed through 100ml of purified water, 0.05g of 4-MPY was added, stirred vigorously until completely dissolved, and 2ml of 0.1M Cd(NO 3 ) 2 solution. After 5h, add 1.8ml of 0.1M Na 2 S aqueous solution. After continuing to stir for 12 hours, centrifuge and wash with water to obtain 4-MPY modified CdS particles.

[0071] SERS test of surface functionalized CdS quantum dots:

[0072] The CdS quantum dots prepared by the above method are used as the surface-enhanced Raman scattering (SERS) substrate, and it is directly confirmed that the CdS quantum dots have SERS activity, such as Figure 4 The SERS of 4-MPY on silver sol, CdTe nanoparticles and the Raman spectrum of 4-MPY respectively. (a) is the SERS spectrum of 4-Mpy adsorbed on CdTe nanoparticles, (b) is the SERS spectrum of 4-Mpy adsorbed on Ag sol (c) is the Raman spectrum of 4-MPY powder. Compared with the Raman spectrum of bulk molecules i...

Embodiment 3

[0075] Surface functionalization of ZnS quantum dots:

[0076] Nitrogen was passed through 100ml of purified water, 0.05g of 4-MPY was added, stirred vigorously until completely dissolved, and 2ml of 0.1M Zn(NO 3 ) 2 solution. After 5h, add 1.8ml of 0.1M Na 2 S aqueous solution. After continuing to stir for 12 hours, centrifuge and wash with water to obtain 4-MPY modified ZnS particles.

[0077] SERS test of surface functionalized ZnS quantum dots:

[0078] The CdS quantum dots prepared by the above method are used as the surface-enhanced Raman scattering (SERS) substrate, and it is directly confirmed that the ZnS quantum dots have SERS activity, such as Figure 5 The SERS of 4-MPY on silver sol, ZnS nanoparticles and the Raman spectrum of 4-MPY respectively. (a) is the SERS spectrum of 4-Mpy adsorbed on CdTe nanoparticles, (b) is the SERS spectrum of 4-Mpy adsorbed on Ag sol (c) is the Raman spectrum of 4-MPY powder.

[0079] Semiconductor ZnS nanoparticles exhibit str...

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Abstract

The SERS test method uses nano semiconductor material as surface enhancement of Raman scattering base, and enhances the SERS signal up to 104 times. Wherein, this invention is fit to cadmium telluride, cadmium sulphide, ZnO, ZnS, lead sulfide, TiO2, Pb3O4 or Pb2O3, and mercaptopyridine, p-aminobenzenethiol, pyridine, sulfhydrylbenzoic acid, 1,4-2[(4-pyridyl) vinyl]-benzene, 2-2bipyridyl or 4-4bipyridyl. This invention has wide application.

Description

technical field [0001] The invention belongs to the technical field of molecular recognition, and in particular relates to a new method for detecting probe molecules by surface-enhanced Raman spectroscopy (SERS) using nano-scale semiconductor materials as substrates. Background technique [0002] Raman spectroscopy belongs to molecular vibration spectroscopy, which can reflect the characteristic structure of molecules. It is widely used in the natural state of molecular recognition and chemisorption of conjugates. However, the Raman scattering effect is a very weak process, and generally its light intensity is only about 10 of the incident light intensity. -10 . Therefore, the Raman signals are very weak, and some kind of enhancement effect is almost always used to study the Raman spectroscopy of surface adsorbed species. [0003] In 1974, after roughening the surface of a smooth silver electrode, Fleischmann et al. obtained for the first time high-quality Raman spectra o...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 赵冰徐蔚青赵纯王延飞孙志华王蕴馨胡海龙
Owner JILIN UNIV
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