63 results about "Metastasis tumor" patented technology

Therapeutic methods for inhibiting the growth of preneoplastic / neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably organic compounds, preferably aromatic and heterocylic sulfonamides, which inhibit the enzymatic activity of MN / CA IX and that are useful for treating patients with preneoplastic / neoplastic disease. Further, the CA IX-specific inhibitors when labeled or linked to an appropriate visualizing means can also be used diagnostically / prognostically for preneoplastic / neoplastic disease, and for imaging use, for example, to detect hypoxic precancerous cells, tumors and / or metastases, by selectively binding to activated CA IX, preferably CA IX activated under hypoxic conditions, and not to inactive CA IX. Such detection of hypoxic conditions can be helpful in determining effective treatment options, and in predicting treatment outcome and the prognosis of disease development. Still further, the CA IX-specific inhibitors can be used therapeutically to selectively target hypoxic cells expressing activated CA IX. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy of hypoxic cells. Alternatively, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to hypoxic preneoplastic / neoplastic cells expressing activated CA IX on their surfaces. In an alternative mode of the invention, CA IX-specific inhibitors may be used therapeutically to target acidic conditions of a tumor, e.g., to increase pHe in order to enhance the efficacy of weak base chemotherapeutic drugs.

The present invention provides a combination therapy for effectively treating and / or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

According to the invention, a carboxylated platinum prodrug is designed and synthesized, and a coordination nano core is prepared by utilizing the coordination effect of ions and the prodrug. Lipid is wrapped outside the nano-core, and a photosensitizer is dispersed in the nano-core to construct the prodrug nano-carrier. A nano prodrug is loaded by utilizing the phagocytic function of macrophages (BMDM), so that a near-infrared light (NIR) activated macrophage-nano prodrug delivery system is prepared. The system has the characteristics of high drug loading capacity, light-operated activation and retention of self activity and functions, and efficient and synchronous drug delivery of primary tumors and metastatic tumors can be realized after intravenous injection. Meanwhile, after primary tumors are irradiated by NIR, drugs can be triggered to be released quickly, chemotherapy-photodynamic combined therapy is achieved, and the purposes of killing tumor cells and activating an immune system are achieved. Through combination of three modes of chemotherapy, photodynamic and immunization, dual treatment of primary and metastatic tumors is finally realized.

The invention provides a method for diagnosing bone metastases in nuclide bone imaging based on deep learning. The method relates to a bone scanning diagnosis classification model, a bone metastasis tumor region segmentation model and a bone metastasis tumor load evaluation and automatic report generation model. By the adoption of the method, the bone metastasis tumor can be judged, automatic region segmentation can be conducted, the recognition accuracy is high, and full-automatic analysis from original image input to report generation is preliminarily achieved.

The invention belongs to the technical field of cells and discloses novel adult stem cells, a method for screening the same, a kit and application thereof. Biopsy samples, in vitro tissue samples, and cell line samples of normal tissues and tumors, precancerous tissues and tumors, carcinogenic tissues and metastatic tumors or cancer tissues of rodent, human or other mammals are screened by using chemotherapeutics and cell markers which are combined so as to obtain the stem cell groups. Moreover, the invention also discloses a method for screening and identifying the stem cells from the mixed cell groups, and the kit; and the method and the kit have the advantages of strong specificity, simplicity, convenience, quickness, practicality and effectiveness. The novel stem cells, the method for screening the same and the kit can be applied to clinic treatment, basis and application research, treatment, tissue engineering, medicine screening, and repairing and regeneration of diseased tissues and organs which loose functions well, and have wide prospect.

The invention relates to a sunitinib sustained-release implant capability for curing solid tumors, such as lung cancer, esophageal cancer, gastric cancer, liver cancer, breast cancer, ovarian cancer, prostatic cancer, bladder cancer, colon cancer and rectum cancer. The invention is characterized in that: the sustained-release implant comprises sunitinib, sustained-release excipient and a certain amount of sustained-release regulator; the sustained-release excipient is mainly one or the combination of the copolymer of glycolic acid and hydroxyacetic acid, polifeprosan, poly (L-lactide-co-ethyl phosphate) and poly (L-lactide-co-propyl phosphate); the sunitinib can be released slowly into part of the tumor during the degradation and adsorption, significantly reducing the systemic toxicity and sustaining the effective medicine concentration simultaneously. The invention has the advantages that: the systemic toxicity of sunitinib can be significantly reduced; the effective medicine concentration can be improved selectively at part of the tumor; the invention can be applied to the prevention of tumor recurrence after operation and chemotherapy and combined therapy of various solid tumors and metastatic tumors that are not suitable for operation.