56 results about "Bone imaging" patented technology

Embodiments of systems and methods for planning and / or delivering an oral or facial endosseous implantation in a patient are described. In certain embodiments, systems according to the invention include a processing module; a bone imaging module that communicates bone data about the patient to the processing module; a surface imaging module that communicates surface data about the patient to the processing module; and the processing module processes the bone data and the surface data into an output that includes three-dimensional (3-D) representation data indicative of at least one of an oral structure and a facial structure of the patient. In certain embodiments, a system includes a fabrication module that produces a physical model based on the 3-D representation data and indicating a planned location of an endosseous implant. In certain embodiments, a system includes a surgical module that guides implantation of an endosseous implant based on the 3-D representation data.

Embodiments of systems and methods for planning and / or delivering an oral or facial endosseous implantation in a patient are described. In certain embodiments, systems according to the invention include a processing module; a bone imaging module that communicates bone data about the patient to the processing module; a surface imaging module that communicates surface data about the patient to the processing module; and the processing module processes the bone data and the surface data into an output that includes three-dimensional (3-D) representation data indicative of at least one of an oral structure and a facial structure of the patient. In certain embodiments, a system includes a fabrication module that produces a physical model based on the 3-D representation data and indicating a planned location of an endosseous implant. In certain embodiments, a system includes a surgical module that guides implantation of an endosseous implant based on the 3-D representation data.

Embodiments of systems and methods for planning and / or delivering an oral or facial endosseous implantation in a patient are described. In certain embodiments, systems according to the invention include a processing module; a bone imaging module that communicates bone data about the patient to the processing module; a surface imaging module that communicates surface data about the patient to the processing module; and the processing module processes the bone data and the surface data into an output that includes three-dimensional (3-D) representation data indicative of at least one of an oral structure and a facial structure of the patient. In certain embodiments, a system includes a fabrication module that produces a physical model based on the 3-D representation data and indicating a planned location of an endosseous implant. In certain embodiments, a system includes a surgical module that guides implantation of an endosseous implant based on the 3-D representation data.

A method of producing an image to aid detection of a change in progress of a disease in a patient is described. In the method, a first image of a distribution of a radioisotope in the patient is obtained. A second image of the distribution of the radioisotope in the patient is also obtained. At least one of the first and second images are then normalized (1:140). One of the images is warped to match the other image using a multiple-segment matching method (1:160). The first image is subtracted from the second image to form a subtraction image (1:220). Finally, the resulting subtraction image is displayed.

The invention provides a method for recognizing an image of carcinoma bone metastasis in bone scan in the technical field of image processing. The method comprises the following steps of: detecting positive information and negative information by extracting a whole body bone scan image of a human body; finding out a reference point according to image information, positioning a key part of the human body, and dividing the image into a plurality of main blocks; extracting a hot spot region by using an adaptive region-specific and characteristic-maximum-based (ARC) hot spot detection algorithm of each region; extracting a characteristic vector according to a hot spot detection result and the original image; using a support vector machine (SVM) training model according to the extracted characteristic vector; testing and modifying an obtained classifying model, and simultaneously performing checking, matching and human body calibration on a recognition result so as to obtain a correct diagnosis report. Compared with other methods of recognizing the image of carcinoma bone metastasis, the hot spot detection precision and patient recognition accuracy are improved, the blank in the new developing field of China is recovered, and a uniform diagnosis standard on carcinoma bone metastasis diagnosis in China is established.

A method and device for detection of bone in meat identifies fragments larger than about 1 mm using spectral optical imaging and ultrasound. Spectral imaging can detect foreign material proximate to the surface and ultrasound can detect material within the sample. The sample is irradiated by light and reflected light or Raman scattered light measured. The sample is similarly irradiated by ultrasound and reflected or transmitted sound waves give a set of amplitude data points, which include temporal delay. These data points are then processed by statistical methods to derive a set of vectors in n-dimensional space, which are compared to a calibrated data set of derived vectors which have distinct identifying loci for each type of surface, are indicative of the presence or absence of defects.

The invention discloses a cone-beam CT multi-directional scanner, which comprises a host machine frame, a cone-beam CT scanning device, a scanning frame and a rotary drive device; the cone-beam CT scanning device is installed on the frame body of the scanning frame, The scanning frame is connected with the host frame through a rotary driving device, so that the scanning frame can turn over inside the host frame. When flipped to a horizontal state, the human body can be scanned in a standing position; when the flipped to a vertical state, a human body can be scanned in a supine position. The cone-beam CT multi-directional scanner of the present invention can change the current situation that it is impossible to obtain three-dimensional bone image data in the upright position of the human body, and can also change the current situation that the image resolution accuracy of the sagittal plane of the CT image is relatively low. Three-dimensional cone-beam CT imaging and two-dimensional DR shaping can be performed in the standing and lying positions to obtain high-quality three-dimensional images of the human skeletal system and soft tissues with high-quality spatial precision and high-quality density precision.

Embodiments of systems and methods for planning and / or delivering an oral or facial endosseous implantation in a patient are described. In certain embodiments, systems according to the invention include a processing module; a bone imaging module that communicates bone data about the patient to the processing module; a surface imaging module that communicates surface data about the patient to the processing module; and the processing module processes the bone data and the surface data into an output that includes three-dimensional (3-D) representation data indicative of at least one of an oral structure and a facial structure of the patient. In certain embodiments, a system includes a fabrication module that produces a physical model based on the 3-D representation data and indicating a planned location of an endosseous implant. In certain embodiments, a system includes a surgical module that guides implantation of an endosseous implant based on the 3-D representation data.

The invention discloses a whole-body bone imaging bone segmentation method based on atlas registration. The method comprises the following steps: acquiring original whole-body bone imaging data collected by professional equipment; subjecting the original whole-body bone imaging data to preprocessing including pollution detection processing, pollution repair processing, standardization processing,registration processing and regularization processing; and according to a deformation segmentation template stored in the system, carrying out segmentation processing on the preprocessed whole-body bone development image to obtain a segmentation result of whole-body bone development. By means of the method, bone positioning can be conducted on an image obtained through single whole-body bone scanning examination, a basis is provided for bone lesion positioning, development quality is improved by automatically reducing a difference through bone development pollution detection and a pollution repair algorithm, and the development difference between different whole-body bone scans is solved; and rapid, accurate and intelligent positioning of the whole-body bone imaging skeleton is achieved.

Presented herein are systems and methods that provide for improved computer aided display and analysis of nuclear medicine images. In particular, in certain embodiments, the systems and methods described herein provide improvements to several image processing steps used for automated analysis of bone scan images for assessing cancer status of a patient. For example, improved approaches for image segmentation, hotspot detection, automated classification of hotspots as representing metastases, and computation of risk indices such as bone scan index (BSI) values are provided.

The invention relates to a bone-seeking 99mTc-IPrDP coordination compound, belonging to the fields of radiopharmaceuticals and nuclear medicine. The structural formula of the bone-seeking 99mTc-IPrDP coordination compound is shown in the specification. The preparation method of the coordination compound is as follows: mixing ligand IPrDP, reducing agent, pH buffer solution and pertechnetic acid (99mTcO<4->) solution to react to obtain an IPrDP coordination compound labeled by technetium-99m. The 99mTc-IPrDP coordination compound is used for nuclear medical diagnostic imaging. Through comparison, the product provided by the invention has the advantages of good product specificity, high bone / tissue intake (Am, bone) (% ID / g) and (Am, bone / Am, blood) and good tissue clearance rate, thus being expected to become novel bone imaging agent.

The invention relates to a human body part segmentation method and system based on SPECT imaging, based on a bone imaging data matrix, a human body region is extracted from a bone imaging image to obtain effective information of the bone imaging data matrix, the calculation amount is reduced, and the segmentation precision is improved. Then the human body area is divided into a head area, a chest area, a pelvic bone area and a leg area based on the data matrix corresponding to the human body area and human morphological characteristics, then the chest area is divided into a trunk area, a left upper limb and a right upper limb based on the data matrix corresponding to the chest area, and finally based on the data matrix corresponding to the leg area, the leg area is divided into the left lower limb and the right lower limb, so that the human body is divided into the head, the trunk, the four limbs, the pelvis and other parts, accurate segmentation of the human body parts is achieved, and accurate segmentation of the head, the trunk, the four limbs, the pelvis and other parts can be effectively conducted on any SPCET bone imaging image.

A computer aided bone scan assessment system and method provide automated lesion detection and quantitative assessment of bone disease burden changes.

The invention provides a method for diagnosing bone metastases in nuclide bone imaging based on deep learning. The method relates to a bone scanning diagnosis classification model, a bone metastasis tumor region segmentation model and a bone metastasis tumor load evaluation and automatic report generation model. By the adoption of the method, the bone metastasis tumor can be judged, automatic region segmentation can be conducted, the recognition accuracy is high, and full-automatic analysis from original image input to report generation is preliminarily achieved.

The invention discloses a novel bone seeking complex. The complex comprises a nuclide <99m>Tc and a ligand, wherein the ligand is a diphosphate derivative containing NO-donors and has a general formula represented by the following formula, wherein R1 is an aliphatic hydrocarbon, an aromatic ring or a nitrogen-containing heterocyclic ring containing 1 to 2 NO-donors; X is a group of -H, -OH, -NH2 and the like; Y is oxygen, sulfur or amino; and n is an integer between 2 and 9. The invention also discloses a preparation method for the complex and application of the complex as a bone imaging agent. Compared with the current bone imaging agent <99m>Tc-MDP widely used in the clinic at home and abroad, the bone imaging agent has high bone tissue initial stage uptake, long stay time and low non-target tissue uptake, particularly low liver uptake, and is expected to become a novel bone imaging agent with better performance.

This invention is directed to a method for quantifying cancer treatment response in patients with bone metastases using computer aided bone scan assessment, comprising:(a) obtaining a bone scan image;(b) normalizing the obtained bone scan image to identify normalized bone scan lesions; and(c) quantitatively assessing the normalized bone scan lesions using bone scan lesion area, bone scan intensity, or bone scan lesion count.

The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with 68Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof.

Disclosed is a method of creating a digital abutment design of a customized dental abutment, the including comprising: obtaining a bone scan comprising a digital representation of at least a part of a patient's jaw including the surface of the jawbone; and designing the digital abutment design of the customized dental abutment; wherein the design of the digital abutment design is at least partly based on fulfilling a set of predefined design criteria including the relationship between the digital representation of the jawbone and the digital abutment design.

The invention relates to a mark product of <89>Zr marked denosumab. The mark product is [<89>Zr]-Df-Bz-NCS-denosumab; and Df-Bz-NCS-denosumab is marked by adopting <89>Zr. The mark product disclosed by the invention is accurate and reliable in development result, proper in half-life period, good in specificity, targeting property and in-vitro stability and higher in radioactive chemical purity; a good imaging effect can be realized; for bone imaging, the mark product is capable of responding internal metabolism conditions of drugs objectively and accurately; and therefore, osteoporosis and solid tumour osseous metastasis can be diagnosed earlier.

The invention provides a preparation capable of bone imaging and bone metastases tumor curing, and belongs to the technical field of bone metastases tumor curing. The preparation is <177>Lu-ibandronicacid. The invention further provides a preparation method of the preparation. According to the preparation method, ibandronic acid is added into a <177>LuCl3 solution, the solution pH is adjusted bymeans of hydrochloric acid, after reaction is carried out at a certain temperature for a certain time, sterilization is conducted, and filtering is conducted to obtain the preparation. According to the preparation capable of bone imaging and bone metastases tumor curing and the preparation method, by combining a radionuclide <177> Lu and the ibandronic acid, the preparation <177>Lu-ibandronic acidcapable of bone imaging and achieving bone metastases tumor curing is provided; the <177> Lu is a bone-seeking imaging agent, a large dose of the <177> Lu has curing action on bone metastases, and the ibandronic acid also has higher action on curing bone metastases, so that the <177>Lu-ibandronic acid preparation can bring the curing action of the radionuclide <177> Lu and the ibandronic acid onthe bone metastases tumor into play better.

The invention provides an unconstrained scanning and voxel-based three-dimensional real-time bone imaging method. According to the method, a voxel-based reconstruction algorithm in a traditional three-dimensional reconstruction technology is applied to skeletal system imaging, a traditional projection method used in the algorithm is optimized and accelerated, and an FDP method is proposed to achieve a real-time reconstruction effect. Because the method provided by the invention is a voxel-based reconstruction algorithm, large-area and large-range imaging (covering the whole back area of a general adult) can be carried out. The method is different from a traditional stacked scanning reconstruction method for three-dimensional bone imaging to the greatest extent. Finally, the technology provided by the invention is also suitable for general non-real-time reconstruction, and is used for accelerating the whole reconstruction process.

The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with 68Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof.

A device for orienting a bone cutting tool with respect to a locking screw hole of an intramedullary nail inserted within a bone is provided. The device includes a device body which is configured with a cutting path for a cutting device and a distal end portion which is adapted for positioning against a surface of the bone. The device also includes an ultrasound probe holder which serves for aligning the cutting path with the screw locking feature using at least one ultrasound signal of at least one ultrasound probe attached to the device.