52 results about "Living birth" patented technology

The present invention relates to the use of an oxytocin receptor antagonist in females undergoing embryo transfer as part of an assisted reproductive technology. In particular, methods are provided for increasing ongoing implantation rate, increasing ongoing pregnancy rate, increasing clinical pregnancy rate, and / or increasing live birth rate in a female subject undergoing embryo transfer. Specifically, the antagonists are released in the luteal phase when the endometrium is receptive for embryo implantation and / or when the embryo has reached the blastocyst-stage.

There is set forth herein an apparatus comprising: a non-contacting array of sensors adapted for positioning at a position spaced from and proximate a position of a patient; and a signal processing circuit in communication with the array of sensors, wherein the signal processing circuit is configured for: generating a plurality of time varying signals using the array of sensors; processing the plurality of time varying signals; and outputting one or more indicator based on the processing. The apparatus can be adapted for use in a variety of applications including emergency applications such as live birth applications in which neonate resuscitation protocols are observed.

Cumulus cell (CC) gene expression is explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention.

Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.

The invention discloses an SNP (single nucleotidepolymorphism) marker related to sow farrowing character as well as a detection method and application thereof. The locus of the SNP marker is a g. 95537674 nucleotide locus on a No.9 chromosome of an international pig genomic 10.2 version reference sequence, belongs to G / T mutation, and corresponds to the 255th site on the SEQ ID NO: 1; the SNP marker has significant correlation with the number of live births of sows. A primer pair for detecting the SNP marker provided by the invention comprises an upstream primer SEQ ID NO: 2 and a downstream primer SEQ ID NO: 3. The SNP marker provided by the invention is related to the farrowing performance of Suhuai sows, so that a high-yield sow strain can be screened through identifying the SNP marker, and the obtained high-yield sow strain has important economic benefit and social value.

The invention discloses a method for improving the test-tube baby clinical outcome by selecting an embryo with good development potential. The method comprises five steps that the transplanting embryo with good development potential is selected mainly according to IL-8 in an embryo culture solution before the transplanting; concretely, a liquid phase chip high-flux protein analysis technology is used for detecting the content of IL-8 in a sample; an IL-8 positive embryo in the culture solution is selected to be combined with a morphology evaluation method to perform transplantation; the IL-8 positive embryo in the culture solution before the transplantation is used for being combined with the morphological high-quality embryo to perform transplantation; the pregnancy rate can be improved by more than 8 percent, and can reach 60.76 percent; compared with the existing transplantation method for selecting the embryo singly by a morphology method, the method provided by the invention has the advantages that the pregnancy rate can be improved by more than 8 percent to 12 percent. When the method is combined with the existing morphology method for selecting high-quality embryo; or the high-quality embryo and the ordinary embryo are transplanted to an in vitro fertilization person, the embryo planting rate can also be improved; the baby live birth number is increased; the patient clinic pregnancy rate is improved; the abortion rate is reduced.

The invention relates to the technology of molecular marker detection, and in particular discloses a sheep prolificacy related SNP molecular marker and an application thereof. Nucleotide on the 71874104bp site (XM_015101463.1, based on version number of sheep genome sequence information: Oar_v4.0, December, 2015) on the No.17 chromosome of sheep is subjected to single nucleotide detection; in accordance with a detection result, it is judged that a sheep HIRA gene is homozygous or heterozygous; and the average number of live births of a multipara ewe is predicted. With the application of the method, automatic detection can be conducted on an SNP site of the histone regulation (HIRA) gene. By selecting sheep HIRA genotype, AG heterozygous individuals and GG homozygous individuals, having a prolificacy character, can be reserved, so that the reproductive capacity of the sheep is improved; and the SNP molecular marker has a potential application value in large-scale molecular breeding of the sheep.

A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with the chemical ingredients and uptake requirements required to recover and prosper during and after the cryopreservation process. The solution supplies nutrients to the specimens that will replenish depletion and damage to the specimens and their mitochondria, spindles and structural features, such as cell walls. One formulation addresses the additional requirements of frozen specimens as opposed to the current media solutions and methods which treat the un-frozen specimens the same as the frozen specimens when recovering them from cryopreservation.

A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human blastocysts is enhanced in vitro by culturing with a prostacyclin agonist, Iloprost. The in vivo implantation potential and live birth potential of an in vitro fertilization embryo is thereby enhanced and establishment of a viable pregnancy is facilitated.