52 results about "Living birth" patented technology

Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.

The present invention relates to the use of an oxytocin receptor antagonist in females undergoing embryo transfer as part of an assisted reproductive technology. In particular, methods are provided for increasing ongoing implantation rate, increasing ongoing pregnancy rate, increasing clinical pregnancy rate, and / or increasing live birth rate in a female subject undergoing embryo transfer. Specifically, the antagonists are released in the luteal phase when the endometrium is receptive for embryo implantation and / or when the embryo has reached the blastocyst-stage.

The present invention relates to the use of an oxytocin receptor antagonist in females undergoing embryo transfer as part of an assisted reproductive technology. In particular, methods are provided for increasing ongoing implantation rate, increasing ongoing pregnancy rate, increasing clinical pregnancy rate, and / or increasing live birth rate in a female subject undergoing embryo transfer. Specifically, the antagonists are released in the luteal phase when the endometrium is receptive for embryo implantation and / or when the embryo has reached the blastocyst-stage.

Systems and methods are provided for provided for automatic evaluation of a human embryo. An image of the embryo is obtained and provided to a neural network to generate a plurality of values representing the morphology of the embryo. The plurality of values representing the morphology of the embryo are evaluated at an expert system to provide an output class representing one of a current quality of the embryo, a future quality of the embryo, a likelihood that implantation of the embryo will be successful, and a likelihood that implantation of the embryo will result in a live birth.

The invention discloses a feed formula for sows. According to the formula, feed is mainly prepared from following raw materials in parts by weight through crushing and even mixing: 50-60 parts of corn flour, 40-50 parts of soybean meal, 20-25 parts of peanut meal, 20-24 parts of bran, 15-20 parts of wheat middling, 10-15 parts of corn gluten meal, 3-5 parts of fish meal, 1-3 parts of table salt, 15-16 parts of soybean oil, 4-5 parts of donkey-hide gelatin, 1-1.4 parts of lysine, 1.5-2 parts of baking soda, 1-1.5 parts of methionine, 1-1.2 parts of choline chloride, 0.8-1.2 parts of yeast, 2-4 parts of multivitamins and 10-12 parts of a traditional Chinese medicine additive. The feed for the sows is reasonable in ratio, rich in nutrition and good in palatability, multiple Chinese herbal medicines are added, the meat quality of animals is improved, the disease resistance is enhanced, the immunity of the animals can be significantly improved, the death and culling rate is decreased, feed absorption is accelerated, reproductive performance of the sows is effectively improved, the number of live births is increased, and the economic benefit is increased; the feed contains no antibiotics and chemical synthetic drugs and is high in safety.

There is set forth herein an apparatus comprising: a non-contacting array of sensors adapted for positioning at a position spaced from and proximate a position of a patient; and a signal processing circuit in communication with the array of sensors, wherein the signal processing circuit is configured for: generating a plurality of time varying signals using the array of sensors; processing the plurality of time varying signals; and outputting one or more indicator based on the processing. The apparatus can be adapted for use in a variety of applications including emergency applications such as live birth applications in which neonate resuscitation protocols are observed.

The invention relates to a method of assessing pregnancy outcome. The inventors investigated endometrial miRNAs associated with pregnancy outcome by studying miRNAs associated with endometrial receptivity, implantation failure and embryo miscarriage. They performed a miRNomic study to find miRNAs that are differentially expressed according to the endometrial receptivity status, compared the endometrial miRNome between receptive patients with negative beta-hCG and receptive patients with positive beta-hCG, and compared the endometrial miRNome between receptive patients with a miscarriage between 8-12 weeks of amenorrhoea and receptive patients with a live birth. They demonstrated miRNA differential expression in endometrial samples according to the pregnancy outcome. Thus, the invention relates to a method of assessing pregnancy outcome of a patient, comprising a step of measuring in a biological sample obtained from said patient the expression level of at least one miRNA selected from the group consisting of miR-455-3p, miR-4423-3p, miR-4445-3p, miR-3128, miR-3201, let-7b-5p, let-7c-5p, miR-4534, miR-214-3p, miR-15b-5p, miR-424-3p, miR-181a-5p, miR-574-3p, miR-92a-3p, miR-320c, let-7d-5p, miR-125a-5p, miR-320a, miR-320b and let-7f-5p.

A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with the chemical ingredients and uptake requirements required to recover and prosper during and after the cryopreservation process. The solution supplies nutrients to the specimens that will replenish depletion and damage to the specimens and their mitochondria, spindles and structural features, such as cell walls. One formulation addresses the additional requirements of frozen specimens as opposed to the current media solutions and methods which treat the un-frozen specimens the same as the frozen specimens when recovering them from cryopreservation.

Cumulus cell (CC) gene expression is explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention.

The present invention discloses unhatched-egg-extract-containing senile cardiovascular disease prevention instant powder, and relates to the technical field of health food products, and the unhatched-egg-extract--containing senile cardiovascular disease prevention instant powder is made from the following raw materials in parts by weight: 5-10 parts of a live-birth unhatched-egg-extract, 8-15 parts of live-birth unhatched-egg yolk powder, 20-25 parts of ginkgo biloba leaf, 15-20 parts of black fungus, 15-20 parts of spinach root, 15-20 parts of coconut powder, 13-16 parts of cattail pollen, 10-15 parts of maltodextrin, 10-15 parts of angelica, 10-15 parts of grape seed, 8-13 parts of cinnamon leaf, 7-11 parts of myotonin rice bran oil, 6-10 parts of cortex periplocae, 6-10 parts of wine residue, 5-8 parts bitter gourd seeds and 4-6 parts of kelp. The unhatched-egg-extract-containing senile cardiovascular disease prevention instant powder has rich nutritional value and good preventive effect, has no side effects after taking, is easy to take, can be quickly dissolved in water, can be easily absorbed and metabolized by human body after taking, and is an effective senile cardiovascular disease prevention product.

A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human blastocysts is enhanced in vitro by culturing with a prostacyclin agonist, Iloprost. The in vivo implantation potential and live birth potential of an in vitro fertilization embryo is thereby enhanced and establishment of a viable pregnancy is facilitated.

The invention discloses an SNP (single nucleotidepolymorphism) marker related to sow farrowing character as well as a detection method and application thereof. The locus of the SNP marker is a g. 95537674 nucleotide locus on a No.9 chromosome of an international pig genomic 10.2 version reference sequence, belongs to G / T mutation, and corresponds to the 255th site on the SEQ ID NO: 1; the SNP marker has significant correlation with the number of live births of sows. A primer pair for detecting the SNP marker provided by the invention comprises an upstream primer SEQ ID NO: 2 and a downstream primer SEQ ID NO: 3. The SNP marker provided by the invention is related to the farrowing performance of Suhuai sows, so that a high-yield sow strain can be screened through identifying the SNP marker, and the obtained high-yield sow strain has important economic benefit and social value.

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for improving endometrial receptivity and a preparation method and application thereof. The preparation accords with traditional Chinese medicine treatment principles, and can supplement and condition viscera, qi, blood and channels and collaterals. The traditional Chinese medicine compound preparation for improving endometrial receptivity is prepared from extracts of traditional Chinese medicine materials including prepared rehmannia root, white peony root, fleece-flower root, ligustrum lucidum ait, cornus officinalis, radix ophiopogonis, morinda officinalis, radix codonopsis, rhizoma cyperi and semen cuscutae. The preparation can improve endometrial receptivity, easily simplifies the treatment step of in-vitro fertilization and embryo transfer, namely test tube baby, increases the pregnancy rate and the live birth rate, and builds effective intervening measures combining traditional Chinese medicine and western medicine. The composite preparation can be used for preparing medicine preparations for treating infertility.

The invention discloses a method for improving the test-tube baby clinical outcome by selecting an embryo with good development potential. The method comprises five steps that the transplanting embryo with good development potential is selected mainly according to IL-8 in an embryo culture solution before the transplanting; concretely, a liquid phase chip high-flux protein analysis technology is used for detecting the content of IL-8 in a sample; an IL-8 positive embryo in the culture solution is selected to be combined with a morphology evaluation method to perform transplantation; the IL-8 positive embryo in the culture solution before the transplantation is used for being combined with the morphological high-quality embryo to perform transplantation; the pregnancy rate can be improved by more than 8 percent, and can reach 60.76 percent; compared with the existing transplantation method for selecting the embryo singly by a morphology method, the method provided by the invention has the advantages that the pregnancy rate can be improved by more than 8 percent to 12 percent. When the method is combined with the existing morphology method for selecting high-quality embryo; or the high-quality embryo and the ordinary embryo are transplanted to an in vitro fertilization person, the embryo planting rate can also be improved; the baby live birth number is increased; the patient clinic pregnancy rate is improved; the abortion rate is reduced.

The invention relates to the field of animal cloning methods, in particular to a method for improving the development efficiency of a porcine cloned embryo. The method mainly comprises the step of adding a uterine fluid of a sow into a basic culture solution for the porcine cloned embryo. By the method, the blastocyst rate during early development of the cloned embryo and the total number of cellsin a blastocyst are significantly increased; a transcriptome sequencing result of the early embryo shows that culture through addition of the uterine fluid of the sow reduces the number of differentially expressed genes between the cloned embryo and a normal in-vivo fertilized embryo; most importantly, through the addition of the uterine fluid of the sow, also increased the fertility rate of therecipient sow of the cloned embryos and the number of litters per litter, the parturition rate of a receptor sow with the cloned embryo and the number of live births are also increased, which means that by the method, the final efficiency of the in-vivo development of the cloned embryo is effectively improved.

The invention provides for a process that enables live-bearing fresh water fish to live and breed in a salt water environment such as an aquarium. The process starts with a live birth of fry in an aquarium where the salinity of the water matches the salinity of amniotic fluids. Once the fry stabilize, the salinity can be gradually increased to match the salinity of a standard salt water aquarium. The fry and their offspring mature, live, and breed in salt water with no future intervention.

The invention relates to the field of animal husbandry, in particular to a method of improving the pregnancy rate of a sow. In order to improve the pregnancy rate of the sow, before and after gestation, by adopting different formulas to feed the sow, the quality of the sow's egg cell is improved, therefore, the pregnancy rate of one fetuses of the sow is improved, the pregnancy rate is up to 94%.After gestation, feed 2 is fed to the sow, the nutrients have balanced collocation, the sow growth status is good, the body weight gain and the back fat thickness are increased, the embryo loss is reduced and the health of newborn piglets is improved, so that the number of live births is up to 12-13 head / fetus, and the weight of each newborn piglet is as high as 1.5-1.6 kg.

The invention discloses an individualized living yield prediction model and a construction method. The construction method comprises the following steps: a, collecting living yield outcome, individualized ovarian function information, individualized biological information and individualized ovarian excretion promoting information of each sample patient; b, extracting parameter variables accordingto the accumulated live birth outcome and the individualized information; c, constructing a semi-parameter generalized additive model gm2 of the parameter variable; d, performing verification and sensitivity analysis on the model gm2, and training and evaluating the stability of the model gm2; and e, drawing a living yield prediction model curve graph. The method has the advantages that guidance can be provided for doctors and patients receiving ART treatment, the possibility of obtaining at least one live delivery infant can be predicted according to the age of the patients and the egg takingnumber, and the patients can be informed whether the live delivery possibility of the patients is remarkably increased or not after the patients receive extra stimulation periods.

The invention relates to the technology of molecular marker detection, and in particular discloses a sheep prolificacy related SNP molecular marker and an application thereof. Nucleotide on the 71874104bp site (XM_015101463.1, based on version number of sheep genome sequence information: Oar_v4.0, December, 2015) on the No.17 chromosome of sheep is subjected to single nucleotide detection; in accordance with a detection result, it is judged that a sheep HIRA gene is homozygous or heterozygous; and the average number of live births of a multipara ewe is predicted. With the application of the method, automatic detection can be conducted on an SNP site of the histone regulation (HIRA) gene. By selecting sheep HIRA genotype, AG heterozygous individuals and GG homozygous individuals, having a prolificacy character, can be reserved, so that the reproductive capacity of the sheep is improved; and the SNP molecular marker has a potential application value in large-scale molecular breeding of the sheep.

A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with the chemical ingredients and uptake requirements required to recover and prosper during and after the cryopreservation process. The solution supplies nutrients to the specimens that will replenish depletion and damage to the specimens and their mitochondria, spindles and structural features, such as cell walls. One formulation addresses the additional requirements of frozen specimens as opposed to the current media solutions and methods which treat the un-frozen specimens the same as the frozen specimens when recovering them from cryopreservation.

The invention discloses unhatched-egg-extract containing healthcare wine for treating rheumatic arthritis and relates to the technical field of healthcare wine. The unhatched-egg-extract containing healthcare wine is prepared from, by weight, 130-150 parts of mead, 5-8 parts of live-birth unhatched egg extract, 20-25 parts of ginkgo leaves, 15-20 parts of lotus leaves, 15-20 parts of buckwheat sprouts, 13-17 parts of hawthorn leaves, 12-16 parts of radix angelicae sinensis, 10-15 parts of divaricate saposhnikovia roots, 10-15 parts of citrus peel, 8-12 parts of taro leaves, 6-10 parts of pawpaws, 5-8 parts of purple perilla, 5-8 parts of red dates, 3-6 parts of lemons, 3-6 part of fresh ginger and 2-4 parts of pepper. The prepared healthcare wine has the remarkable rheumatic arthritis treatment effect, contains rich nutrient substances, is free of any side effect after being drunk, and is a novel product capable of effectively treating rheumatic arthritis.

The invention discloses feed for improving reproductive performance of a lactating sow. The feed comprises the following components as raw materials in parts by weight: 50-60 parts of corn, 20-23 parts of soybean meal, 6-15 parts of bran, 6-12 parts of rice bran, 0.1-1 part of calcium hydrogen phosphate, 0.5-2 parts of stone powder, 0.1-1 part of table salt, 0.01-0.1 part of trace elements, 0.01-0.1 part of vitamins and 1-6 parts of a pomace fermentation material. The invention further discloses a preparation method of the feed. The feed for enhancing the reproductive performance of the sow isprepared by mixing the pomace fermentation material and the other raw materials according to a specific formula and the specific preparation method, and the feed can significantly improve the digestive capacity and the nutrient absorbing capacity of the sow to improve the physique of the sow and promote rapid reproduction of the sow so as to achieve the purpose of improving the reproductive performance of the sow; and when the sow is fed during the first three months of pregnancy and during weaning, the number of live births of the sow is significantly increased, the lactating capacity is significantly improved and the number of weaned piglets is significantly increased, so that the reproductive performance of the sow is improved.

The invention discloses a nurse rabbit, comprising an adult rabbit shaped shell; the adult rabbit shaped shell is bestrewn with real rabbit skin villi; the back of the adult rabbit shaped shell is provided with through holes; an electric heating rod is arranged in the adult rabbit shaped shell; connecting wires of the electric heating rod are led out from the through holes and are connected with a constant-temperature adjustable attaching plug; the tail of the adult rabbit shaped shell is provided with cleaning holes with plugs; the belly of the adult rabbit shaped shell is provided with two rows of nipples communicated with the shell. The nurse rabbit is reasonable in structure design and convenient in baby rabbit feeding and solves the technical problem that in the prior art, as the baby rabbits can not be fed by mother rabbits, healthy growth of the baby rabbits is affected. The nurse rabbit is characterized in that the whole body is bestrewn with real rabbit skin villi, therefore, the nurse rabbit has good softness and has double heat preservation effects on the baby rabbits and the milk in the shell; milk sources for feeding are diversified, and anti-disease medicines can be added; the temperature of the milk liquid for feeding is adjustable; high live birth indexes of the baby rabbits contribute to high economic benefits and long service life.

The invention discloses a composite ewe feed. The composite ewe feed is prepared by crushing the raw materials according to weight parts and uniformly mixing the crushed raw materials. The composite ewe feed has the following raw materials: 80-100 parts of niblet, 25-35 parts of soybean meal, 12-18 parts of wheat straw, 8-10 parts of barley husk, 20-30 parts of bagasse pith, 2-6 parts of mulberry leaf, 20-30 parts of peanut vine, 3-5 parts of poplar leaf, 6-8 parts of pawpaw powder, 50-80 parts of sunflower stem, 40-60 parts of sweet potato vine, 6-8 parts of hawthorn, 3-5 parts of silkworm chrysalis powder, 2-4 parts of chicken liver powder, 0.4-0.8 parts of ferrous sulfate heptahydrate, 0.1-0.3 parts of zinc sulfate heptahydrate, 0.4-0.8 parts of manganese sulfate, 0.1-0.3 parts of sodium sulfite, 0.2-0.4 parts of progesterone, 3-5 parts of a phagostimulant, 1-3 parts of composite vitamin and 1-3 parts of salt. The ewe feed has the advantages that the feed proportion is reasonable, the nutrition is abundant, a plurality of Chinese herbal medicines is added, the meat quality is improved, the disease resistance is enhanced, animal immunization capability is obviously increased, ewe breeding performance can be effectively increased, and the number of live birth is increased.

A method of producing a preparation of embryonic DNA that can be performed without risking damage to a developing embryo is described. A sample of cell-free media in which an embryo was grown in vitro from the 4-blastomeres stage to the blastocyst stage of development is obtained, wherein the sample comprises cell-free embryonic DNA (cfeDNA). cfeDNA is obtained from the sample and recovered. These steps can be carried out non-invasively, without performing a biopsy of the embryo. The method can be used for optimizing the likelihood of a live birth after implantation of human egg fertilized in vitro, and for reducing the risk of damage to a normal embryo that has been fertilized in vitro.

The invention discloses a method for improving sow reproductive performance. The method includes: using a cordyceps strain fermentation product as a feed additive to feed sows. The cordyceps strain fermentation product is adopted to feed the sows, nest average birth, nest average live birth, piglet newborn average weight, 21-day-old weaned piglet number, 21-day-old weaned piglet average weight and21-day-old weaned nest average weight of the sows can be increased remarkably, oestrus interval time of the sows is reduced, sow oestrus rate and expression level of estradiol and progesterone are increased, and the sow reproductive performance is improved.

The invention discloses a method for increasing a survival rate of piglets, wherein rational delivery is implemented to female pigs according to time intervals of birth of the piglets, whether stillbirth takes place and delivery behaviors of the female pigs; when the quantity of the born piglets exceeds an effective quantity of nipples of the female pig, in-batch lactation is carried out during a colostrum period, and rational fostering is carried out through a fostering method combining a stage method and an equalization method 24 hours later since the birth. According to the method, the stillbirth quantity of the born piglets can be obviously reduced and the number of live births can be increased. Meanwhile, management in the colostrum period and the fostering work are carried out during a lactation period, so that the survival rate and a uniformity degree during lactation of the piglets can be increased, and the quantity of the weaned piglets and weaning weights can be increased.

The invention discloses a Chinese herbal preparation for improving sow fertility, a preparation method thereof and application thereof. The Chinese herbal preparation is prepared from, by weight, 20 g of the fruit of Chinese wolfberry, 30 g of glossy privet fruit, 30 g of Semen Cuscutae, 30 g of Herba Leonuri, 30 g of Radix Codonopsis, 25 g of Rhizoma Atractylodis Macrocephalae, 25 g of Chinese yam rhizome, 30 g of Herba Epimedii, 20 g of Herba Cistanches and 15 g of clove. The invention further discloses the application of the Chinese herbal preparation in increasing total number born per litter, the number of live births per littler, the number of strong births per litter, average weight of newborn per litter, and otherness; the result shows that a pill for more three piglets is added in the sow feed, so that the sow fertility is improved.