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Traditional Chinese medicine compound preparation for improving endometrial receptivity and preparation method and application thereof

A technology of endometrium and compound preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, diseases, etc., can solve the problems of aggravating patients' physical and mental distress and economic burden, increasing the probability of fresh embryo transfer, and increasing the number of visits to the doctor, etc. , to improve the poor environment of endometrial implantation, increase the probability of fresh embryo transfer, and improve the effect of endometrial receptivity

Inactive Publication Date: 2016-10-05
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Studies have shown that the long program applied to young women and the short program applied to elderly women (also known as the classic program) have gradually produced the following disadvantages. Among them, the long time and large dosage of ovulation induction drugs cause obvious clinical complications, Mainly manifested in ovarian hyperstimulation syndrome (OHSS), the incidence of moderate and severe ovarian hyperstimulation syndrome is 10-30%; OHSS is an iatrogenic disease caused by ovulation induction therapy, mainly manifested in systemic vascular permeability Systemic lesions such as pleural effusion, ascites, insufficient effective blood circulation, liver and kidney damage, and respiratory dysfunction caused by sexual changes, which are life-threatening in severe cases; The risk of bleeding and patients' concerns about estrogen-dependent diseases such as ovarian cysts and breast tumors; in addition, the treatment cycle is significantly prolonged and the number of visits to the doctor is increased, which aggravates the patient's physical and mental distress and economic burden
[0004] With the development of IVF-ET technology, the micro-stimulation ovulation induction program has gradually attracted the attention and application of the field of reproductive medicine, and has also been widely recognized and accepted by patients; however, practice shows that in micro-stimulation (or mild stimulation) treatment Endometrial receptivity is negatively affected, thus resulting in a low likelihood (<10%) of fresh embryo transfer, and most patients require frozen embryo transfer
[0005] In view of the disadvantages of serious complications, long time and high cost in the traditional ovulation induction scheme of the prior art, the inventor of the present application intends to provide a Chinese medicine compound preparation for improving endometrial receptivity, so as to treat , Supplement and regulate viscera, qi and blood and meridians, improve endometrial receptivity, increase the probability of fresh embryo transfer, improve the success rate of fresh embryo transfer, and further increase the pregnancy rate and live birth rate

Method used

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  • Traditional Chinese medicine compound preparation for improving endometrial receptivity and preparation method and application thereof
  • Traditional Chinese medicine compound preparation for improving endometrial receptivity and preparation method and application thereof
  • Traditional Chinese medicine compound preparation for improving endometrial receptivity and preparation method and application thereof

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Effect test

Embodiment 1

[0036] Example 1 Preparation of traditional Chinese medicine compound preparation for improving endometrial receptivity

[0037]Take the raw materials of the following composition: Rehmannia glutinosa, Radix Paeoniae Rubra, Polygoni multiflorum, Ligustrum lucidum, Cornus officinalis, Morinda officinalis Dangsheng, Cuscuta cyperus; according to the weight ratio of the raw materials in each pair of traditional Chinese medicines, the extracts of each raw drug are made into granules ; Firstly, each Chinese herbal medicine is made into decoction pieces with a diameter of 0.1mm to 3mm, dried, and then packaged with non-toxic heat-sealed paper by an automatic granule packaging machine to be directly compatible and decocted. Small packages of 6g, 9g, 10g, 12g, and 30g, the Chinese herbal medicine in the small package accounts for one-half to two-thirds of the volume of the packaging bag; 20-500 times, using a vacuum packaging machine for vacuum packaging; taking samples, and making mi...

Embodiment 2

[0038] Example 2 In vivo experiment

[0039] Preliminary clinical trials have been carried out on this compound preparation, and the results show that: this compound preparation can significantly supplement and regulate viscera, qi and blood, and meridians, improve endometrial receptivity (including thickness, shape, blood flow, etc.), and increase fresh embryo transfer. Chance, improve the success rate of fresh embryo transfer.

Embodiment 3

[0040] Embodiment 3 clinical trial research

[0041] 1. Patient enrollment selection

[0042] Patients receiving IVF-ET treatment (between 25 and 40 years old), without the following conditions, PCOS, obesity (BMI ≥ 30), hydrosalpinx, no uterine cavity lesions (adhesions, polyps), smoking;

[0043] Clinically determined as patients with kidney deficiency and Qi deficiency; according to the age group of patients, they are divided into normal response group (36-40 years old), and then according to the degree of ovarian response to ovulation induction drugs (number of retrieved eggs, high-quality embryos) number) were again divided into multiple embryo group (≥4) and low embryo group (≤3) for stratified research;

[0044] 2. Observe the effect of applying this compound preparation on the thickness, shape and blood flow of the patient's intima

[0045] According to the grouping, the patients were divided into the compound preparation treatment group and the non-treatment group b...

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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for improving endometrial receptivity and a preparation method and application thereof. The preparation accords with traditional Chinese medicine treatment principles, and can supplement and condition viscera, qi, blood and channels and collaterals. The traditional Chinese medicine compound preparation for improving endometrial receptivity is prepared from extracts of traditional Chinese medicine materials including prepared rehmannia root, white peony root, fleece-flower root, ligustrum lucidum ait, cornus officinalis, radix ophiopogonis, morinda officinalis, radix codonopsis, rhizoma cyperi and semen cuscutae. The preparation can improve endometrial receptivity, easily simplifies the treatment step of in-vitro fertilization and embryo transfer, namely test tube baby, increases the pregnancy rate and the live birth rate, and builds effective intervening measures combining traditional Chinese medicine and western medicine. The composite preparation can be used for preparing medicine preparations for treating infertility.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating endometriosis and a preparation method thereof. Background technique [0002] According to literature reports, infertility has become a serious health problem affecting family health. When traditional treatment methods (ovulation induction, hysteroscopic surgery, artificial insemination, etc.) fail, in vitro fertilization-embryo transfer (IVF-ET, commonly known as " Test-tube baby) has become the most effective means of infertility treatment. Affected by the delay of marriage and childbearing age and various factors, the number of cases receiving IVF-ET treatment in my country is on the rise. In vitro fertilization-embryo transfer treatment includes controlled ovulation induction (COH), surgical egg retrieval, in vitro fertilization, embryo culture and embryo transfer, etc. In these multiple links, controlle...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61P15/08A61P15/00
Inventor 童国庆戴德英
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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