40results about How to "Improved implant" patented technology

Systems and methods for enhanced implantation of an electrode lead for neuromuscular electrical stimulation of tissue associated with control of the lumbar spine for treatment of back pain, in a midline-to-lateral manner are provided. The implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system without disruption of the electrode lead post-implantation due to anatomical structures.

A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers is provided, as well as enriched populations of mesenchymal precursor cells and compositions comprising the cells. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilizing MACS recognizing expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilising two colour FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.

A bone plate formed of a fiber-reinforced polymer composite, comprising a radiopaque marker that delineates at least a part of the contour of the plate. In some embodiments, the radiopaque marker comprises a metal wire section embedded proximal to an edge of the contour, for example at a distance of 1 mm from an edge of the contour. In some embodiments, the radiopaque marker extends along a head portion of the plate, and / or along a stem portion of the plate. In some embodiments, the metal wire is formed as an intermittent line. Alternatively, the wire is formed as a continuous line.

An assembly for wireless energy communication to an implanted device comprises an external belt (7) accommodating a wearer control (1) followed by controller (2), a battery pack (4), an inverter (3), a transmission coil (8) connected in parallel by a plurality of capacitors, and an infrared transceiver 9. Provided furthermore is an implanted device comprising a receiver coil (11) having the same dimensions as the transmission coil (8), a rectifier following said receiver coil (11), an infrared transceiver (10) followed by a controller and an sensor assembly (17) assigned thereto as well as a battery pack (16) for powering said implanted device via an energy manager (14).

Radiolucent composite implants. Some embodiments include reconfiguration indicators. Some embodiments include radio-opaque markers, especially along contours. Some embodiments are provided in kit form with accessories such as radiolucent drill guides and / or drives. Some embodiments have fiber reinforcement adapted for various usage scenarios. Some embodiments include metal components, for example, to increase strength. Also described are manufacturing methods.

A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilizing MACS recognizing expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilizing two color FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.

Methods for treating surfaces of polymeric substrates (as used in medical implants) with inert plasmas to promote the growth of bioentities (such as cells) on these surfaces is disclosed. The treated surfaces are subsequently exposed to an environment to form functionalities associated with enhanced growth of the bioentity on the surface. For example, the substrate may be exposed to the ambient environment. The bioentity may then be deposited on the modified surface. This inert plasma treatment and exposure to a suitable environment does not degrade the implants, and thus improved implants are created. Also, due to the specific functional groups at the modified surface, high cell densities are achieved.

The invention discloses a metal bone supporter for medical bone substitute, which comprises a supporter and a connector component; every component of the metal bone supporter is functionally and structurally designed according to anatomical data and biomechanical data; the data of the supporter component is input to an electron beam melting fabrication device, and titanium alloy powders in the device is able be scanned, melted and molded through electron beams, to form a cylinder with the strength and elastic modulus similar to cancellous bones of human body; the supporter component is a porotic spongy body structure with threads on an end, and porous structure forms a rough surface; The connector component is made through mechanical treatment, with smooth surface and dense solid mass inside, and thread on an end, and is connected to the supporter component as a removable body. The invention has the porous structure for bone growing, high surface friction coefficient, stable structures and mechanical properties similar to bones, and is able to support the femoral head necrosis parts, slow down the necrosis speed and prolong or avoid the hip joint replacement. Thus, the invention is convenient for popularization and application.

Several tools and simplified implant methods utilizing minimal surgical intrusion into a subject are disclosed for the proper inserting, advancement and positioning of a subcutaneous implantable medical device (IMD). A kit disclosed herein includes a poker for penetrating the skin and generating a small incision, a tissue spreader for increasing the incision width and an introducer and cannula for the proper insertion of the ILR subcutaneously. Diverse IMDs can be implanted using the kit, tools and methods included in the disclosure, including implantable pulse generators (IPGs), implantable loop recorders (ILRs) for collecting and transmitting cardiac activity signals and implantable cardioverter-defibrillators (ICDs) for delivering high voltage cardiac therapy via electrodes spaced from the myocardium.

Medical implants are formed at least in part from porous metal wherein the pores of the metal are filled with a hardenable material. The hardenable material can be used to assist in the manufacture of the implant, permitting detailed machining of the implant. Further, the hardenable material can be a resorbable material that strengthens the implant during implantation but is resorbed, once implanted, to permit bone growth and infiltration. Further, in an alternate embodiment, the hardenable material can be a thermoplastic material that can be heated by ultrasonic energy to create an adhesive bond between a fastener and bone structure.

An improved medical implant for treating mitral regurgitation is provided. The medical implant comprises proximal and distal anchors connected by a bridge. The medical implant is configured to be delivered into a coronary sinus using a minimially invasive procedure. The bridge is preferably made of a shape memory material which is biased to contract after the implant is delivered. The medical implant further comprises a reinforcement mechanism configured to limit stresses and strains along the length of the bridge. In a preferred embodiment, the reinforcement mechanism is fixed to a plurality of attachment points along the bridge, thereby preventing excessive elongation between any two attachment points. A resorbable material is preferably disposed within gaps along the length of the bridge to temporarily maintain the bridge in an elongated condition. After the proximal and distal anchors are secured in the coronary sinus, the resorbable material gradually resorbs, thereby creating tension in the bridge which applies a force along the mitral valve annulus. The reinforcement mechanism ensures that stresses and strains and distributed evenly while the bridge is in tension.

Planar index guided vertical cavity surface emitting laser (PIG VCSEL) utilizes index guiding to provide improved optical confinement and proton implantation to improve current confinement. Index guiding is achieved by etching index guide openings (holes or partial ridges) around the optical confinement region and may be adjusted by varying the etched volume of the index guide openings (holes and partial ridges). The top contact surface area is increased in the PIG VCSEL thereby lowering contact and device resistance to improve VCSEL performance further. The PIG VCSEL is a substantially planarized device for ease of manufacture.

A spinal implant for implantation within a spinal facet joint is provided. The spinal implant may include a main body including opposing top and bottom surfaces, opposing front or distal and rear or proximal surfaces, and opposing side surfaces. At least one retaining feature may be associated with at least one surface of the main body to frictionally engage the implant within the spinal facet joint. At least one securement feature may be associated with at least one surface of the main body to selectively secure the implant within the spinal facet joint.

A fixation component for a bone-supporting component of a bone implant, comprising a body including a core, and a head portion. A distal end of the component comprises an insert formed of a hard material, which covers a portion of the distal end, and acts a thread cutting tool. In some embodiments, the insert comprises a planar portion abutting against a material of the fixation component. In some embodiments, the fixation component is a screw, and the insert covers at least a portion of a cutting edge of the screw.

Methods of improving embryo implantation are disclosed and comprise contacting a receptive uterus and / or an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.

A method for manufacturing a MOS transistors in a semiconductor device includes the step of implanting a dopant in a channel layer or source / drain regions by using a multi-step implantation and an associated multi-step heat treatment, wherein the multi-step implantation includes a number of steps of implantation each for implanting the dopant at a dosage lower than 1×1013 / cm2. The total dosage of the multi-step implantation ranges between 1×1013 / cm2 and 3×1013 / cm2.

It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions is provided. As a result, the time required for the formation of a stereoscopic bond can be shortened and, moreover, a bond can be self-repaired owning to cell actions even in the case where a pair of the bond is injured by a wound, etc. As a material for designing a scaffold, titanium fibers of less than 100 μm in size and having an aspect ratio of 20 or more are selected. Then these fibers are entangled together to form a layer which is integrally fixed by vacuum sintering to a periphery surface of the various implant bodies, and coated with apatite. The fact that the layer contains spaces of an excellent ability to induce a biological hard tissue and fix the same is proved by the material, in which the layer is fixed to the periphery of an implant.

Medical implants are formed at least in part from porous metal wherein the pores of the metal are filled with a hardenable material. The hardenable material can be used to assist in the manufacture of the implant, permitting detailed machining of the implant. Further, the hardenable material can be a resorbable material that strengthens the implant during implantation but is resorbed, once implanted, to permit bone growth and infiltration. Further, in an alternate embodiment, the hardenable material can be a thermoplastic material that can be heated by ultrasonic energy to create an adhesive bond between a fastener and bone structure.

Systems and methods for enhanced implantation of an electrode lead for neuromuscular electrical stimulation of tissue associated with control of the lumbar spine for treatment of back pain, in a midline-to-lateral manner are provided. The implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system without disruption of the electrode lead post-implantation due to anatomical structures.

A method and related apparatus for the minimally invasive implantation about a heart of at least a deployable device such as a heart assist device or cardiac compression device. The method comprises the steps of performing a left thoracotomy or subxiphoid incision; obtaining access to the pericardial sac; making a generally linear incision in the pericardial sac; positioning an assembly having an insertion aperture member with an upper ring and a lower ring or flange and insertion tube having therein a deployable device. The apparatus of the present invention includes an insertion aperture member having an upper ring and a lower ring or flange; and an insertion tube having therein a deployable device adapted to be deployed from the insertion tube inside the pericardial sac via a generally linear incision.

A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilizing MACS recognizing expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilizing two colour FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.

A method and related apparatus for the minimally invasive implantation about a heart of at least a deployable device such as a heart assist device or cardiac compression device. The method comprises the steps of performing a left thoracotomy or subxiphoid incision; obtaining access to the pericardial sac; making a generally linear incision in the pericardial sac; positioning an assembly having an insertion aperture member with an upper ring and a lower ring or flange and insertion tube having therein a deployable device. The apparatus of the present invention includes an insertion aperture member having an upper ring and a lower ring or flange; and an insertion tube having therein a deployable device adapted to be deployed from the insertion tube inside the pericardial sac via a generally linear incision.

A dental implant that comprises a top section having a C first length, an intermediate section having a second length, and a bottom section having a third length, wherein the first length corresponds to the third length by a preset ratio, wherein the third length corresponds to the sum of the first length and the second length by the preset ratio, and wherein the preset ratio is in the range of 1.5-1.7.

A metal bone supporter for medical bone substitute including a supporter and a connector component which are functionally and structurally designed according to anatomical data and biomechanical data. The titanium alloy powders in the device are able to be scanned, melted and molded through electron beams, to form a cylinder with the strength and elastic modulus similar to cancellous bones of the human body. The supporter component is a porotic spongy body structure with threads on an end, and porous structure forms a rough surface. The connector component is made with a smooth surface and a dense solid mass inside, a thread on an end, and is connected to the supporter component as a removable body. The porous structure enables bone growth, and the device has a high surface friction coefficient, and has a stable structure and mechanical properties are similar to bones.

A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilising MACS recognising expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilising two colour FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.