Nanodevice and method for in vivo monitoring and release of drugs are provided. The disclosed nanodevice is characterized in having a drug-loaded nanosphere that is capable of releasing the encapsulated drugs upon magnetically stimulation. The nanodevice may also be used as a contrast agent for in vivo imaging and monitoring the concentration and distribution of the released drugs and / or active compounds injected separately into a target site of a subject.
The invention discloses a hydrophobic drug nanometer capsule of pH response of near-infrared fluorescent trace and a preparation method of the hydrophobic drug nanometer capsule and belongs to the technical field of preparation of nanometer materials. The hydrophobic drug nanometer capsule is applied to research of in-vivo imaging, cancer treatment and drug trace. The hydrophobic drug nanometer capsule of pH response of near-infrared fluorescent trace, which is wrapped with hydrophobic anticancer drugs and Ag2s nanometer particles, responds to pH (degraded in the acidic environment) and is in the diameter of 70-150 nm, has stable dispersibility in water phase, emits stable and strong near-infrared second-district fluorescent light under excitation of 808 nm, and can be used for tracing drug in real time in the blood circulation and the tumor position. The preparation method of the hydrophobic drug nanometer capsule is novel and simple, a drug carrier has cancercell target and pH response characteristics as compared with a reported drug transport carrier and can emit near-infrared second-district fluorescent light, fluorescent signals are strong and can be used for tracing drug in real and identifying curative effect.