33 results about "Ibuprofen arginine" patented technology

The invention relates to a preparation method of ibuprofen arginine salt, belonging to the technical field of pharmaceutical chemistry. The preparation method of the ibuprofen arginine salt comprises the following steps of: firstly adding arginine and ethanol for heating and stirring; and then adding ibuprofen to obtain the ibuprofen arginine salt through crystallization, temperature reduction, standing, filtering and drying. The invention can well solve the dissolution problem in the reaction process and the crystallization problem after reaction, and has the advantages of simple process, easy implementation, reliable quality and high yield.

The present invention provides a preparation method of granules containing ibuprofen arginine composite, and the described composite is formed from ibuprofen arginine, diluting agent and adhesive, and said preparation method includes two steps of granurating and coating, and uses the coating material containing silicon dioxide to make coating liquor, and uses the prepared coating liquor to coat the granules. Said granules can be tabletted, also cna be capsulized, and the conventional solid soage form prepared by using said method has good stability, quick disintegration speed and high biological utilization rate.

The invention discloses a preparation method of an arginine ibuprofen salt. The method is that ibuprofen is adopted to dissolve into ethanol with 95 percent concentration and added with solid arginine while stirring, and then heated to 40 to 80 DEG C, stirred for 15 to 60 minutes, after reaction, cooled to room temperature and crystallized. The preparation method of the invention adopts that the solid arginine is directly added to the ibuprofen solution and no solvent is added before the solid arginine addition, thus shortening production technique steps and reducing reaction equipment. The process that directly crystallization from mother liquid in room temperature, need not be added with other solvent to dilute, thus reducing consumption of solvent and kinds, shortening production technique flow; as the solvent can be recycled and reused, thus reducing production cost and saving energy.

The invention relates to an ibuprofen arginine granule, which is composed of ibuprofen arginine, a filler, a taste masking agent, an adhesive, a flavoring agent, a smelling agent, and a coloring agent by weight part. The invention also provides a preparation method of the ibuprofen arginine granule. The ibuprofen arginine granule provided by the invention covers up the intrinsic spicy taste of ibuprofen arginine, and has the advantages of good children compliance, fast effect, simple prescription composition, easily available and cheap auxiliary materials with fewer variety and dosage, and no need of coating. The preparation method has the characteristics of simple process, easy operation, no need for special equipment, short production cycle, and low cost, thus being suitable for industrialized production.

The invention relates to a stable ibuprofen arginine injection and a preparation method thereof. The injection comprises ibuprofen, arginine, and meglumine. Also, sodium dihydrogen phosphate and sodium thiosulfate can be contained in the injection. The injection can be an injection liquid, a transfusion liquid or a lyophilized powder injection. The ibuprofen arginine injection provided by the invention brings no problem in respects of haemolyticus, vascular stimulation or allergy. When a prior product is diluted by using physiological saline or a 5% glucose injection, a white opalescence or turbid phenomenon is occurred. With the injection and the preparation provided by the invention, the problem is solved, the physical stability problem of the product is solved, and the quality stability and safety of the product are ensured.

The invention relates to a preparation method of ibuprofen arginine salt. The method comprises the following steps of: reacting ibuprofen with arginine in water; and after reacting, drying a reaction liquid. In the preparation method provided by the invention, an arginine solid and an ibuprofen solid are directly added into a reaction kettle, and purified water is added for reacting, so that the use of an organic solvent is avoided, the problem of environmental pollution is solved, and the production cost is reduced. After the reaction, drying is performed directly, and the organic solvent is not contacted, so that the production cost is reduced, the problem of environmental pollution is avoided, the yield is increased, and the production safety is enhanced. The method has the advantages of mild reaction conditions, implementation at the room temperature, reduction in energy consumption, energy saving, reduction in cost and environmental friendliness.

A composite medicine of ibuprofen, arginine and codeine is proportionally prepared from ibuprofen, arginine and codeine or its pharmacologically acceptable salt.It has high water solubility and less stimulation to stomach and intestine.

The invention discloses an ibuprofen medicine composition for injection, which consists of ibuprofen and arginine glutamate, and is characterized in that the weight ratio of the ibuprofen to the arginine glutamate is 1:1.44. A preparation method of the medicine composition comprises the following steps of: taking injection water with weight being 70 percent of prescribed dosage, adding the arginine glutamate with prescribed dosage at 70-80DEG C, and agitating the mixture for dissolution; adding the ibuprofen with prescribed dosage and agitating the mixture till the ibuprofen is fully dissolved; adding medicinal charcoal into the solution, evenly agitating the mixture and standing the mixture; conducting suction filtration, replenishing the injection water to full dosage and evenly mixing the solution; determining the initial PH (potential of hydrogen) value, and regulating the pH value to 7.7 plus or minus 0.2 by using 4% sodium hydroxide solution and 10% hydrochloric acid solution according to the initial pH value; conducting refined filtration and filling; conducting sterilization; conducting lamp inspection; and warehousing the product to obtain the finished product. The ibuprofen medicine composition has high light stability, is reliable in quality and has more obvious advantages for product yield improvement, cost reduction, industrialization realization and better clinical application.

The invention discloses an ibuprofen injection for intravenous administration and a preparation method thereof. The ibuprofen injection for intravenous administration consists of ibuprofen, arginine, a cosolvent and water for injection. The cosolvent is Poloxamer 188. The ibuprofen injection disclosed by the invention has stable quality, high aseptic level, moderate pH and good compatibility in clinical application. The preparation method of the ibuprofen injection disclosed by the invention has the advantages of simple and efficient process, controllable quality, and is beneficial to large-scale industrial production.

The present invention relates to an orally disintegrating tablet of febrifuge and analgesic ibuprofen arginine and a preparing method thereof. The orally disintegrating of ibuprofen arginine according to the invention is composed of active component of ibuprofen arginine and appropriate medical supplementary material. The weight percent is as follows: 20%-60% of ibuprofen arginine, and 40%-80% of supplementary material. The supplementary material comprises the following components: one component or a plurality of components selected from thinning agent (filling agent), disintegrating agent, adhesive, wetting agent, lubricant, flavor correcting agent, colorant and effervescence disintegrating agent. The orally disintegrating of ibuprofen arginine can adopt the flavor correcting agent, mucilage, packing technique or integratedly use the plurality of methods for covering the biting taste of principal agent. The orally disintegrating of ibuprofen arginine of the invention has the advantages of excellent mouth feel, no requirement of water in medicine taking, quick disintegrating in oral cavity, quickly medicine releasing in stomach, guarantee of quick function, better hardness, no requirement of special device in production process and suitability of industrial production.

The invention belongs to the technical field of medicine synthesis and in particular relates to a method for preparing an amide impurity of an ibuprofen arginine injection. The method comprises the following steps: under the action of a catalyst, an acylation reaction of ibuprofen and an acylation reagent firstly is performed to obtain an ibuprofen acylation intermittent; secondly, a salting reaction with arginine is performed to obtain a crude ibuprofen arginine injection amide impurity product, then the crude ibuprofen arginine injection amide impurity product is fed through a methanol column rapidly, and methanol is concentrated to obtain a pure amide impurity. The method for preparing the amide impurity of the ibuprofen arginine injection, which is provided by the invention, has the advantages of being simple and feasible in process, short in course, gentle in reaction condition, easy in raw material obtaining, free of pollution, simple in reaction aftertreatment, and the like.

The invention discloses a medicine compound containing ibuprofen arginine and a preparation method thereof. The medicine compound containing ibuprofen arginine comprises the following components in parts by weight: 1 part of ibuprofen arginine, 0.5-50 parts of saccharose, 0.5-50 parts of stearic acid and 0.05-5 parts of purified water. The medicine compound containing ibuprofen arginine according to the invention has simple components, includes two accessories of saccharose and stearic acid except for ibuprofen arginine, not only can effectively solve the problem of pungent smell of ibuprofen arginine and tastes nice, but also is low in production cost. Besides, the medicine compound containing ibuprofen arginine provided by the invention adopts water as a wetting agent, not only has the problem of ethyl alcohol residue, but also guarantees the medication safety of the patient suffering from alcohol allergy.

The invention discloses an ibuprofen pharmaceutical composition, comprising ibuprofen, arginine and tween. According to the invention, by adding tween in the ibuprofen and arginine solution, the stability of the ibuprofen pharmaceutical composition in clinic application is improved. Experiments show that the ibuprofen pharmaceutical composition solution can be stable for 48 hours after being diluted by using normal saline, glucose injection or Sodium Lactate Ringer's Injection.