33 results about "Ibuprofen arginine" patented technology

The invention discloses a method for preparing ibuprofen arginine salts. In the invention, arginine is added in ibuprofen ethanol sollution under the ambient temperature and agitation, salt precipitation and crystallization are performed in a container in order. The preparing process is simple, convenient, high in yield, good in reproduction. The ibuprofen arginine salts can be used in preparing oral preparations and injections, is good for quickening adsorption speed, increasing bioavailability and enlarging application range.

The present invention provides a preparation method of granules containing ibuprofen arginine composite, and the described composite is formed from ibuprofen arginine, diluting agent and adhesive, and said preparation method includes two steps of granurating and coating, and uses the coating material containing silicon dioxide to make coating liquor, and uses the prepared coating liquor to coat the granules. Said granules can be tabletted, also cna be capsulized, and the conventional solid soage form prepared by using said method has good stability, quick disintegration speed and high biological utilization rate.

The invention relates to a preparation method of ibuprofen arginine salt, belonging to the technical field of pharmaceutical chemistry. The preparation method of the ibuprofen arginine salt comprises the following steps of: firstly adding arginine and ethanol for heating and stirring; and then adding ibuprofen to obtain the ibuprofen arginine salt through crystallization, temperature reduction, standing, filtering and drying. The invention can well solve the dissolution problem in the reaction process and the crystallization problem after reaction, and has the advantages of simple process, easy implementation, reliable quality and high yield.

The invention relates to a stable ibuprofen arginine injection and a preparation method thereof. The injection comprises ibuprofen, arginine, and meglumine. Also, sodium dihydrogen phosphate and sodium thiosulfate can be contained in the injection. The injection can be an injection liquid, a transfusion liquid or a lyophilized powder injection. The ibuprofen arginine injection provided by the invention brings no problem in respects of haemolyticus, vascular stimulation or allergy. When a prior product is diluted by using physiological saline or a 5% glucose injection, a white opalescence or turbid phenomenon is occurred. With the injection and the preparation provided by the invention, the problem is solved, the physical stability problem of the product is solved, and the quality stability and safety of the product are ensured.

The invention relates to an ibuprofen arginine medicament for children and its use in treating children's toothache, aches caused by trauma (such as sport injury), knuckle and ligament ache, back pain, headache, and fever caused by common cold, acute upper respiratory tract infection disease or acute laryngitis. The dosage types of the preparation include powder, tablets, capsules or liquid preparations.

The present invention relates to an orally disintegrating tablet of febrifuge and analgesic ibuprofen arginine and a preparing method thereof. The orally disintegrating of ibuprofen arginine according to the invention is composed of active component of ibuprofen arginine and appropriate medical supplementary material. The weight percent is as follows: 20%-60% of ibuprofen arginine, and 40%-80% of supplementary material. The supplementary material comprises the following components: one component or a plurality of components selected from thinning agent (filling agent), disintegrating agent, adhesive, wetting agent, lubricant, flavor correcting agent, colorant and effervescence disintegrating agent. The orally disintegrating of ibuprofen arginine can adopt the flavor correcting agent, mucilage, packing technique or integratedly use the plurality of methods for covering the biting taste of principal agent. The orally disintegrating of ibuprofen arginine of the invention has the advantages of excellent mouth feel, no requirement of water in medicine taking, quick disintegrating in oral cavity, quickly medicine releasing in stomach, guarantee of quick function, better hardness, no requirement of special device in production process and suitability of industrial production.

The invention relates to a preparation method of ibuprofen arginine salt. The method comprises the following steps of: reacting ibuprofen with arginine in water; and after reacting, drying a reaction liquid. In the preparation method provided by the invention, an arginine solid and an ibuprofen solid are directly added into a reaction kettle, and purified water is added for reacting, so that the use of an organic solvent is avoided, the problem of environmental pollution is solved, and the production cost is reduced. After the reaction, drying is performed directly, and the organic solvent is not contacted, so that the production cost is reduced, the problem of environmental pollution is avoided, the yield is increased, and the production safety is enhanced. The method has the advantages of mild reaction conditions, implementation at the room temperature, reduction in energy consumption, energy saving, reduction in cost and environmental friendliness.

The present invention provides a preparation method of granules containing ibuprofen arginine composite, and the described composite is formed from ibuprofen arginine, diluting agent and adhesive, and said preparation method includes two steps of granurating and coating, and uses the coating material containing silicon dioxide to make coating liquor, and uses the prepared coating liquor to coat the granules. Said granules can be tabletted, also cna be capsulized, and the conventional solid soage form prepared by using said method has good stability, quick disintegration speed and high biological utilization rate.

The invention relates to preparation methods of ibuprofen arginine powder injection for injection, relating to preparation methods of ibuprofen arginine powder injection, which are used for solving the problems of being complex, high in cost and high in quality control difficulty in the traditional ibuprofen preparation method. The first method comprises the following steps of: mixing ibuprofen and arginine, and adding the mixture into purified water to be stirred till the mixture is completely dissolved so as to obtain a solution; carrying out ultra-filtration of the solution under a sterile environment, and split charging in a sterile manner; and freezing and drying to obtain white frozen powder, namely the ibuprofen arginine powder injection for injection. The second method comprises the following steps of: after dissolving the arginine into the purified water, adding the ibuprofen to obtain a solution; carrying out ultra-filtration of the solution under a sterile environment, and split charging in a sterile manner; and freezing and drying to obtain white frozen powder, namely the ibuprofen arginine powder injection for injection. Recovery, separation and crystallization of a solvent are not required. The methods disclosed by the invention are simple in process, low in cost, free from solvent residual, high in product yield and easy for quality control, wherein the product yield can be up to 93.1-95.8%.

The invention discloses a preparation method of an arginine ibuprofen salt. The method is that ibuprofen is adopted to dissolve into ethanol with 95 percent concentration and added with solid arginine while stirring, and then heated to 40 to 80 DEG C, stirred for 15 to 60 minutes, after reaction, cooled to room temperature and crystallized. The preparation method of the invention adopts that the solid arginine is directly added to the ibuprofen solution and no solvent is added before the solid arginine addition, thus shortening production technique steps and reducing reaction equipment. The process that directly crystallization from mother liquid in room temperature, need not be added with other solvent to dilute, thus reducing consumption of solvent and kinds, shortening production technique flow; as the solvent can be recycled and reused, thus reducing production cost and saving energy.

The invention provides an intravenous administration preparation which can be directly used without being diluted and contains arginine and ibuprofen at a molar rate of 0.92, wherein the adding amount of sodium chloride is 0.75-0.9 percent by weight per volume. The intravenous administration preparation is prepared by the following steps of: a, adding injection water into a dosing tank, and adding ibuprofen, sodium chloride and arginine according to ingredient amount; b, stirring the mixture, and regulating pH value to about 7.4 by using 10 percent of sodium hydroxide solution, adding the injection water to the required amount, adding activated carbon for injection, stirring, removing carbon by using a titanium rod, and performing fine filtering on the mixture by microporous filter membrane (preferably, a cylindrical filter with the pore diameters of 0.45 microns or 0.22 microns); c, filling the injection after the detection of an intermediate is qualified; and d, feeding the filled semi-finished product into a sterilization cabinet for sterilizing in a hot-pressing mode.

The invention relates to a method for preparing ibuprofen arginine salt, which includes: reacting ibuprofen and arginine in C1-C4 fatty alcohol, cooling until crystals are precipitated after the reaction is completed, and collecting and drying the crystals to obtain the ibuprofen arginine salt. The solid raw material and the liquid raw material are directly reacted by a one-step method, complex steps and process of dissolving and charging respectively are avoided, a synthesis process step and reaction equipment are omitted, solvent usage is greatly reduced, and conditions are mild by using a cooling crystallization method. In a word, the method for preparing ibuprofen arginine salt has the advantages of short operating steps, simple process, easiness in implementation, low cost, reliability in quality, high yield and the like, and is more applicable to massive industrial production.

The invention discloses an ibuprofen medicine composition for injection, which consists of ibuprofen and arginine glutamate, and is characterized in that the weight ratio of the ibuprofen to the arginine glutamate is 1:1.44. A preparation method of the medicine composition comprises the following steps of: taking injection water with weight being 70 percent of prescribed dosage, adding the arginine glutamate with prescribed dosage at 70-80DEG C, and agitating the mixture for dissolution; adding the ibuprofen with prescribed dosage and agitating the mixture till the ibuprofen is fully dissolved; adding medicinal charcoal into the solution, evenly agitating the mixture and standing the mixture; conducting suction filtration, replenishing the injection water to full dosage and evenly mixing the solution; determining the initial PH (potential of hydrogen) value, and regulating the pH value to 7.7 plus or minus 0.2 by using 4% sodium hydroxide solution and 10% hydrochloric acid solution according to the initial pH value; conducting refined filtration and filling; conducting sterilization; conducting lamp inspection; and warehousing the product to obtain the finished product. The ibuprofen medicine composition has high light stability, is reliable in quality and has more obvious advantages for product yield improvement, cost reduction, industrialization realization and better clinical application.

The invention belongs to the technical field of pharmacy and in particular provides dextral ibuprofen arginine. The molecular formula of the dextral ibuprofen arginine is C19H32N4O4; the molecular weight is 380.48178[g / mol]; the structural formula is shown as (I); the dextral ibuprofen arginine is white powder and well soluble in water; the pH value of 20 percent aqueous solution is 6.5; the melting point is 170 to 172 DEG C; and the optical rotation is dextral. The dextral ibuprofen arginine has the characteristic of high solubility in water and can be prepared into various water-soluble preparations according to clinical requirements; the formula does not comprise cosolvents such as alcohol and the like; and the aqueous solution is neutral. The dextral ibuprofen arginine is absorbed by a human body easily, can relieve irritation on a gastrointestinal tract, and has antifebrile, antalgic and anti-inflammatory effects.

A composite medicine of ibuprofen, arginine and codeine is proportionally prepared from ibuprofen, arginine and codeine or its pharmacologically acceptable salt.It has high water solubility and less stimulation to stomach and intestine.

The compound preparation contains ibuprofen-arginine and pseudoephedrine or its pharmaceutically accedptable salt in the weight ratio of 1-40. The combination of ibuprofen with arginine results in raised water solubility of ibuprofen to increase the absorption rate in body and reduce the irritation to gastrointestinal tract. The compound preparation has fast, stable and lasting curative effect.

The invention belongs to the field of pharmaceutical chemistry and discloses a preparation method of ibuprofen-arginine. The preparation method is characterized by comprising the following steps of: under the conditions of room temperature and stirring, simultaneously dissolving ibuprofen and arginine in an alcohol-water solution by using the difference between solubility of the components, then adding a right amount of alcohol to clear reaction liquid, salifying and crystallizing. The preparation method has the advantages of simple preparation technology, mild reaction conditions, low cost, high yield, controlled quality and suitability for industrial production.

The invention relates to an ibuprofen arginine tablet which comprises, by weight, 90.01 to 99.00% of ibuprofen arginine, with the balance being adjuvant. The invention further relates to a preparation method for the ibuprofen arginine tablet. In the tablet provided by the invention, the content of ibuprofen arginine is greater than 90%, and a small amount of the adjuvant is contained; the tablet has better stability and higher security; after granulation, the tablet undergoes coating, so a better taste masking effect is obtained, and an obtained granule has better fluidity and smaller hygroscopicity. The preparation method provided by the invention has the advantages of a simple process, a short production period, high efficiency, more effective conservation of production cost and suitability for large scale industrial production.

The invention relates to a preparation method of ibuprofen arginine salt. The method comprises the following steps of: reacting ibuprofen with arginine in water; and after reacting, drying a reaction liquid. In the preparation method provided by the invention, an arginine solid and an ibuprofen solid are directly added into a reaction kettle, and purified water is added for reacting, so that the use of an organic solvent is avoided, the problem of environmental pollution is solved, and the production cost is reduced. After the reaction, drying is performed directly, and the organic solvent is not contacted, so that the production cost is reduced, the problem of environmental pollution is avoided, the yield is increased, and the production safety is enhanced. The method has the advantages of mild reaction conditions, implementation at the room temperature, reduction in energy consumption, energy saving, reduction in cost and environmental friendliness.

A composite medicine of ibuprofen, arginine and codeine is proportionally prepared from ibuprofen, arginine and codeine or its pharmacologically acceptable salt.It has high water solubility and less stimulation to stomach and intestine.

The invention discloses a medicine compound containing ibuprofen arginine and a preparation method thereof. The medicine compound containing ibuprofen arginine comprises the following components in parts by weight: 1 part of ibuprofen arginine, 0.5-50 parts of saccharose, 0.5-50 parts of stearic acid and 0.05-5 parts of purified water. The medicine compound containing ibuprofen arginine according to the invention has simple components, includes two accessories of saccharose and stearic acid except for ibuprofen arginine, not only can effectively solve the problem of pungent smell of ibuprofen arginine and tastes nice, but also is low in production cost. Besides, the medicine compound containing ibuprofen arginine provided by the invention adopts water as a wetting agent, not only has the problem of ethyl alcohol residue, but also guarantees the medication safety of the patient suffering from alcohol allergy.

The invention discloses an ibuprofen medicine composition for injection, which consists of ibuprofen and arginine glutamate, and is characterized in that the weight ratio of the ibuprofen to the arginine glutamate is 1:1.44. A preparation method of the medicine composition comprises the following steps of: taking injection water with weight being 70 percent of prescribed dosage, adding the arginine glutamate with prescribed dosage at 70-80DEG C, and agitating the mixture for dissolution; adding the ibuprofen with prescribed dosage and agitating the mixture till the ibuprofen is fully dissolved; adding medicinal charcoal into the solution, evenly agitating the mixture and standing the mixture; conducting suction filtration, replenishing the injection water to full dosage and evenly mixing the solution; determining the initial PH (potential of hydrogen) value, and regulating the pH value to 7.7 plus or minus 0.2 by using 4% sodium hydroxide solution and 10% hydrochloric acid solution according to the initial pH value; conducting refined filtration and filling; conducting sterilization; conducting lamp inspection; and warehousing the product to obtain the finished product. The ibuprofen medicine composition has high light stability, is reliable in quality and has more obvious advantages for product yield improvement, cost reduction, industrialization realization and better clinical application.

The invention discloses an ibuprofen injection for intravenous administration and a preparation method thereof. The ibuprofen injection for intravenous administration consists of ibuprofen, arginine, a cosolvent and water for injection. The cosolvent is Poloxamer 188. The ibuprofen injection disclosed by the invention has stable quality, high aseptic level, moderate pH and good compatibility in clinical application. The preparation method of the ibuprofen injection disclosed by the invention has the advantages of simple and efficient process, controllable quality, and is beneficial to large-scale industrial production.

The present invention relates to an orally disintegrating tablet of febrifuge and analgesic ibuprofen arginine and a preparing method thereof. The orally disintegrating of ibuprofen arginine according to the invention is composed of active component of ibuprofen arginine and appropriate medical supplementary material. The weight percent is as follows: 20%-60% of ibuprofen arginine, and 40%-80% of supplementary material. The supplementary material comprises the following components: one component or a plurality of components selected from thinning agent (filling agent), disintegrating agent, adhesive, wetting agent, lubricant, flavor correcting agent, colorant and effervescence disintegrating agent. The orally disintegrating of ibuprofen arginine can adopt the flavor correcting agent, mucilage, packing technique or integratedly use the plurality of methods for covering the biting taste of principal agent. The orally disintegrating of ibuprofen arginine of the invention has the advantages of excellent mouth feel, no requirement of water in medicine taking, quick disintegrating in oral cavity, quickly medicine releasing in stomach, guarantee of quick function, better hardness, no requirement of special device in production process and suitability of industrial production.

The invention belongs to the technical field of medicine synthesis and in particular relates to a method for preparing an amide impurity of an ibuprofen arginine injection. The method comprises the following steps: under the action of a catalyst, an acylation reaction of ibuprofen and an acylation reagent firstly is performed to obtain an ibuprofen acylation intermittent; secondly, a salting reaction with arginine is performed to obtain a crude ibuprofen arginine injection amide impurity product, then the crude ibuprofen arginine injection amide impurity product is fed through a methanol column rapidly, and methanol is concentrated to obtain a pure amide impurity. The method for preparing the amide impurity of the ibuprofen arginine injection, which is provided by the invention, has the advantages of being simple and feasible in process, short in course, gentle in reaction condition, easy in raw material obtaining, free of pollution, simple in reaction aftertreatment, and the like.

The invention discloses a medicine compound containing ibuprofen arginine and a preparation method thereof. The medicine compound containing ibuprofen arginine comprises the following components in parts by weight: 1 part of ibuprofen arginine, 0.5-50 parts of saccharose, 0.5-50 parts of stearic acid and 0.05-5 parts of purified water. The medicine compound containing ibuprofen arginine according to the invention has simple components, includes two accessories of saccharose and stearic acid except for ibuprofen arginine, not only can effectively solve the problem of pungent smell of ibuprofen arginine and tastes nice, but also is low in production cost. Besides, the medicine compound containing ibuprofen arginine provided by the invention adopts water as a wetting agent, not only has the problem of ethyl alcohol residue, but also guarantees the medication safety of the patient suffering from alcohol allergy.

The invention provides a salifying preparation process of ibuprofen arginine. A mode of firstly adding water is adopted, high temperature heating is performed to adjust the feeding sequence and the interval time of adding the ibuprofen and the arginine, the specific heating temperature and heating time are set, and vacuum drying is performed after mixing and stirring. The problems encountered by material transfer can be reduced while it is guaranteed that qualified and uniform samples are obtained; meanwhile, residual temperature vacuum drying is performed in situ, the drying time is shorter and the safety is also guaranteed.