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Compound prepn. contg. Brufen arginine codeine

A technology of arginine codeine and compound preparations, which can be applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of slow onset of action and gastrointestinal stimulation, and achieve rapid onset of action , Improve water solubility, improve the effect of human body absorption rate

Inactive Publication Date: 2005-01-05
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But, because the ibuprofen in this composition is almost insoluble in water, pharmacokinetic parameter T max (The time to reach the maximum blood concentration) is 1.5-2h. Like other oral NSAIDs (non-steroidal anti-inflammatory drugs), the onset of action is relatively slow, and it has a certain stimulating effect on the gastrointestinal tract.

Method used

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  • Compound prepn. contg. Brufen arginine codeine
  • Compound prepn. contg. Brufen arginine codeine
  • Compound prepn. contg. Brufen arginine codeine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: Preparation of ibuprofen arginine codeine compound tablet

[0070]Prescription (per 1000 tablets):

[0071] Ibuprofen Arginine 370g

[0072] Codeine Phosphate 12.5g

[0073] Lactose 37.5g

[0074] Starch 37.5g

[0075] Microcrystalline Cellulose 15g

[0076] 2% povidone aqueous solution 25ml

[0077] Talc powder 2.8g

[0078] Magnesium stearate 0.9g

[0079] Process:

[0080] (1) Pass the raw materials and auxiliary materials through an 80-mesh sieve respectively;

[0081] (2) get ibuprofen arginine and codeine phosphate prescription quantity and mix with starch, then add lactose, microcrystalline cellulose and mix;

[0082] (3) Add 2% povidone aqueous solution to make soft material, granulate, dry at 70°C, granulate with 16 meshes, add talcum powder and magnesium stearate, mix evenly, and compress into tablets.

Embodiment 2

[0083] Embodiment 2: Preparation of ibuprofen arginine codeine compound capsule

[0084] Prescription (per 1000 capsules):

[0085] Ibuprofen Arginine 570g

[0086] Codeine Phosphate 12.5g

[0087] Hydroxypropyl ethyl cellulose 10g

[0088] Starch 5g

[0089] Micronized silica gel 5g

[0090] Process:

[0091] (1) respectively process ibuprofen arginine and codeine phosphate, hydroxypropyl ethyl cellulose, starch, micropowder silica gel of prescription quantity and cross 40 mesh sieves, mix homogeneously;

[0092] (2) Pack capsules.

Embodiment 3

[0093] Embodiment 3: Preparation of ibuprofen arginine codeine compound sustained-release tablet

[0094] Prescription (per 1000 tablets)

[0095] Sustained release tablet core:

[0096] Ibuprofen Arginine 400g

[0097] Lactose 30g

[0098] HPMC60g

[0099] (Hydroxypropylmethylcellulose)

[0100] Ethyl cellulose 20g

[0101] Magnesium stearate 8.2g

[0102] Immediate release layer:

[0103] Ibuprofen Arginine 500g

[0104] Codeine Phosphate 12.5g

[0105] Coloring layer:

[0106] Opadry 45g

[0107] Process:

[0108] (1) According to the above prescription, with 75% ethanol as a wetting agent, the sustained-release tablet core group is distributed with profen arginine, lactose, HPMC, ethyl cellulose and mixed evenly according to the prescription amount to make granules, add hard Magnesium fatty acid is used as a lubricant, and compressed into tablets to obtain sustained-release tablet cores;

[0109...

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Abstract

A composite medicine of ibuprofen, arginine and codeine is proportionally prepared from ibuprofen, arginine and codeine or its pharmacologically acceptable salt.It has high water solubility and less stimulation to stomach and intestine.

Description

(1) Technical field [0001] The invention relates to a compound preparation containing ibuprofen arginine and codeine or a pharmaceutically acceptable salt composition thereof. (2) Background technology [0002] Codeine or its pharmaceutically acceptable salts (such as codeine phosphate) are considered by those skilled in the art to directly inhibit the cough center of the brain and have a strong antitussive effect. Ibuprofen, a non-steroidal anti-inflammatory drug, is also known to have antipyretic, anti-inflammatory, and analgesic effects. Therefore, the oral composition containing both ibuprofen and codeine or a pharmaceutically acceptable salt thereof is suitable for severe dry cough and irritating cough caused by various reasons, especially for severe dry cough accompanied by chest pain. Its analgesic effect can be used for moderate pain, such as postoperative pain and moderate cancer pain. [0003] But, because the ibuprofen in this composition is almost insoluble in ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K9/52A61K31/485A61P11/14
Inventor 陆峰胡雅芳
Owner CHINA PHARM UNIV
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