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Method for preparing ibuprofen arginine salt

A technology of arginine salt and arginine, which is applied in the field of preparation of ibuprofen arginine salt, can solve the problem that the preparation method cannot be reproduced and the like, and achieves a technology with good reproducibility, simple preparation process and high yield. Effect

Inactive Publication Date: 2008-08-13
北京法玛赛科医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation methods of the above two patents cannot be reproduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take by weighing ibuprofen 10.3g, be dissolved in dehydrated alcohol 35ml, obtain ibuprofen ethanol solution; At room temperature and under stirring, add arginine 9.3g in the ibuprofen ethanol solution gradually, after adding 10ml of water and ethanol, continue to stir until the solution is transparent; continue to stir for about 15 minutes and become turbid, then stir for about 4 hours; filter, wash twice with 10ml of cold absolute ethanol, and vacuum dry at 50°C to obtain a white solid, which is Buluo Fen arginine salt.

Embodiment 2

[0012] Weigh ibuprofen 10.3g, dissolve it in 45ml of dehydrated ethanol to obtain ibuprofen ethanol solution; at room temperature and under stirring, gradually add arginine 9.3g in the ibuprofen ethanol solution, after adding, the reaction solution If it is opaque, add a little ethanol and continue to stir until the solution is transparent; continue to stir for about 15 minutes and then turn cloudy, then stir for about 4 hours; filter, wash twice with 10ml of cold absolute ethanol, and vacuum dry at 50°C to obtain white The solid is ibuprofen arginine salt.

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PUM

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Abstract

The invention discloses a method for preparing ibuprofen arginine salts. In the invention, arginine is added in ibuprofen ethanol sollution under the ambient temperature and agitation, salt precipitation and crystallization are performed in a container in order. The preparing process is simple, convenient, high in yield, good in reproduction. The ibuprofen arginine salts can be used in preparing oral preparations and injections, is good for quickening adsorption speed, increasing bioavailability and enlarging application range.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a preparation method of ibuprofen arginine salt. Background technique [0002] Ibuprofen (Ibuprofen) is a phenylpropionic acid non-steroidal anti-inflammatory analgesic, which has strong antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects, and its curative effect is similar to that of aspirin and phenylbutazone. Phenol is good, and the gastrointestinal side effects are mild and well tolerated. It is an antipyretic and analgesic widely used at present. The dosage forms of ibuprofen listed both at home and abroad include ordinary tablets, sustained-release tablets, capsules, suspensions, suppositories, creams, etc. [0003] Ibuprofen is widely used clinically as a phenylpropionic acid antipyretic and analgesic with definite curative effect, less adverse reactions and high safety. But because ibuprofen is almost insoluble in water, it brings a lot of inconvenience ...

Claims

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Application Information

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IPC IPC(8): C07C57/30A61K31/192A61K31/198A61P29/00
Inventor 刘杏敏
Owner 北京法玛赛科医药科技有限公司
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