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Ibuprofen medicine composition for injection

A composition and injection technology, which is applied in the pharmaceutical field in the field of medicine, can solve problems such as safety risks, inconvenient use, storage and transportation, and achieve the effects of good stability, reduced market risk, and stable quality

Active Publication Date: 2014-06-18
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] The ibuprofen injection produced by the prior art has very strict requirements on storage and protection from light, which is inconvenient in use, storage and transportation
At the same time, a large number of non-injection-grade pharmaceutical excipients are added, which brings great risks to the safety of clinical applications

Method used

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  • Ibuprofen medicine composition for injection
  • Ibuprofen medicine composition for injection
  • Ibuprofen medicine composition for injection

Examples

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Comparison scheme
Effect test

Embodiment 1

[0072] Every 1000 described ibuprofen pharmaceutical compositions, its formula consists of:

[0073] Ibuprofen 400g

[0074] Arginine Glutamate 576g

[0075] Add water for injection to 4L.

[0076] Preparation process: Take 70% of the prescribed amount of water for injection, at a temperature of 70-80 ° C, add the prescribed amount of arginine glutamic acid, stir to dissolve; add the prescribed amount of ibuprofen, stir until completely dissolved; add to the above solution Add 0.2% medicinal charcoal in the amount of liquid medicine, stir evenly, and place; filter with suction, add water for injection to the full amount, and mix well; measure the initial pH value, according to the initial pH value, use 4% sodium hydroxide solution and 10% Hydrochloric acid solution adjusts the pH range to 7.7±0.2; fine filtration; filling; sterilization; light inspection; storage; the finished product is obtained.

Embodiment 2

[0078] Every 1000 described ibuprofen pharmaceutical compositions, its formula consists of:

[0079] Ibuprofen 800g

[0080] Arginine Glutamate 1152g

[0081] Add water for injection to 8L.

[0082] Preparation process: with embodiment 1.

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Abstract

The invention discloses an ibuprofen medicine composition for injection, which consists of ibuprofen and arginine glutamate, and is characterized in that the weight ratio of the ibuprofen to the arginine glutamate is 1:1.44. A preparation method of the medicine composition comprises the following steps of: taking injection water with weight being 70 percent of prescribed dosage, adding the arginine glutamate with prescribed dosage at 70-80DEG C, and agitating the mixture for dissolution; adding the ibuprofen with prescribed dosage and agitating the mixture till the ibuprofen is fully dissolved; adding medicinal charcoal into the solution, evenly agitating the mixture and standing the mixture; conducting suction filtration, replenishing the injection water to full dosage and evenly mixing the solution; determining the initial PH (potential of hydrogen) value, and regulating the pH value to 7.7 plus or minus 0.2 by using 4% sodium hydroxide solution and 10% hydrochloric acid solution according to the initial pH value; conducting refined filtration and filling; conducting sterilization; conducting lamp inspection; and warehousing the product to obtain the finished product. The ibuprofen medicine composition has high light stability, is reliable in quality and has more obvious advantages for product yield improvement, cost reduction, industrialization realization and better clinical application.

Description

technical field [0001] The invention relates to medicines in the medical field, in particular to a pharmaceutical composition of ibuprofen for injection with little skin irritation and a preparation method thereof. Background technique [0002] Pain is a complex physiological and psychological activity, and it is one of the most common clinical symptoms. It includes the pain sensation caused by noxious stimuli acting on the body and the body's pain response to noxious stimuli. Pain can be used as a warning that the body is injured, triggering a series of defensive protective reactions in the body, which is a symbol of danger signals and prompts people to act urgently to avoid danger and eliminate harm. [0003] Fever is caused by the action of fever activators on the body, which in turn leads to the generation of endogenous pyrogens (EP) that merge into the brain and act on the thermoregulatory center, which in turn leads to the release of mediators in the fever center and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/192A61K47/16A61P29/00
Inventor 黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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