Ibuprofen fat emulsion injection and preparation method thereof
A technology for injection and fat emulsion, which can be used in emulsion delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. High bioavailability, prolonged duration of action, high stability and safety
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Embodiment 1
[0030] prescription:
[0031]
[0032] Preparation process: filter soybean oil and lecithin with microporous membrane respectively, put them into the container according to the above amount, heat to about 50°C, stir evenly, and make the oil phase; add ibuprofen into the oil phase, mix homogeneously to obtain a mixed solution; put water for injection in another container, add glycerin, stir evenly, and filter through a 0.45 μm microporous membrane to make an aqueous phase; mix the mixed solution containing ibuprofen, soybean oil and lecithin with After high-speed stirring at 1800rpm, pour it into the aqueous phase containing glycerin to make colostrum, adjust the pH of the solution to 8.0 with sodium hydroxide solution; transfer the prepared colostrum into a high-pressure homogenizer, homogenize, and set the pressure at 880bar , under the condition of temperature 45±2°C, high-pressure cycle 3 times to obtain emulsion, filter the emulsion through 5μm microporous membrane, fil...
Embodiment 2
[0034] prescription:
[0035]
[0036] Preparation process: with embodiment 1.
Embodiment 3
[0038] prescription:
[0039]
[0040] Preparation process: with embodiment 1.
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