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Ibuprofen medicine composition for injection

A composition and injection technology, applied in the field of medicines in the field of medicine, can solve problems such as safety risks, inconvenience in use, storage and transportation, and achieve the effects of good stability, reduced market risks, and simple and easy methods.

Active Publication Date: 2013-04-10
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0026] The ibuprofen injection produced by the prior art has very strict requirements on storage and protection from light, which is inconvenient in use, storage and transportation
At the same time, a large number of non-injection-grade pharmaceutical excipients are added, which brings great risks to the safety of clinical applications

Method used

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  • Ibuprofen medicine composition for injection
  • Ibuprofen medicine composition for injection
  • Ibuprofen medicine composition for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] For every 1000 pieces of the ibuprofen pharmaceutical composition, the formula is as follows:

[0074] Ibuprofen 400g

[0075] Arginine Glutamic Acid 576g

[0076] The water for injection is increased to 4L.

[0077] Preparation process: Take 70% of the prescription amount of water for injection, the temperature is 70-80℃, add the prescription amount of arginine glutamic acid, stir to dissolve; add the prescription amount of ibuprofen, stir until the dissolution is complete; add to the above solution Add 0.2% medicinal charcoal of the amount of medicinal solution, stir evenly, place; filter with suction, add water for injection to the full amount, and mix well; measure the initial pH value, according to the initial pH value, use 4% sodium hydroxide solution and 10% The hydrochloric acid solution adjusts the pH value in the range of 7.7±0.2; fine filtration; filling; sterilization; light inspection; storage; the finished product is obtained.

Embodiment 2

[0079] For every 1000 pieces of the ibuprofen pharmaceutical composition, the formula is as follows:

[0080] Ibuprofen 800g

[0081] Arginine Glutamic Acid 1152g

[0082] The water for injection is increased to 8L.

[0083] Preparation process: the same as in Example 1.

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Abstract

The invention discloses an ibuprofen medicine composition for injection, which consists of ibuprofen and arginine glutamate, and is characterized in that the weight ratio of the ibuprofen to the arginine glutamate is 1:1.44. A preparation method of the medicine composition comprises the following steps of: taking injection water with weight being 70 percent of prescribed dosage, adding the arginine glutamate with prescribed dosage at 70-80DEG C, and agitating the mixture for dissolution; adding the ibuprofen with prescribed dosage and agitating the mixture till the ibuprofen is fully dissolved; adding medicinal charcoal into the solution, evenly agitating the mixture and standing the mixture; conducting suction filtration, replenishing the injection water to full dosage and evenly mixing the solution; determining the initial PH (potential of hydrogen) value, and regulating the pH value to 7.7 plus or minus 0.2 by using 4% sodium hydroxide solution and 10% hydrochloric acid solution according to the initial pH value; conducting refined filtration and filling; conducting sterilization; conducting lamp inspection; and warehousing the product to obtain the finished product. The ibuprofen medicine composition has high light stability, is reliable in quality and has more obvious advantages for product yield improvement, cost reduction, industrialization realization and better clinical application.

Description

technical field [0001] The invention relates to medicines in the medical field, in particular to a pharmaceutical composition of ibuprofen for injection with little skin irritation and a preparation method thereof. Background technique [0002] Pain is a complex physiological and psychological activity, and it is one of the most common clinical symptoms. It includes the pain sensation caused by noxious stimuli acting on the body and the body's pain response to noxious stimuli. Pain can be used as a warning that the body is injured, triggering a series of defensive protective reactions in the body, which is a symbol of danger signals and prompts people to act urgently to avoid danger and eliminate harm. [0003] Fever is caused by the action of fever activators on the body, which in turn leads to the generation of endogenous pyrogens (EP) that merge into the brain and act on the thermoregulatory center, which in turn leads to the release of mediators in the fever center and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/192A61K47/16A61P29/00
Inventor 黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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