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Water-soluble ibuprofen pharmaceutical composition

A composition and drug technology, applied in the field of medicine, can solve the problems of poor water solubility of ibuprofen

Active Publication Date: 2016-01-20
南通春秋软件科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Through a large number of experiments, the applicant has surprisingly found that adding Tween to the solution of ibuprofen and arginine not only solves the problem of poor water solubility of ibuprofen, but also the prepared composition solution is effective in sodium chloride injection. Or the stability in glucose injection or sodium lactate Ringer's injection has been significantly improved, especially the stability in normal saline has been extremely significantly improved, obviously better than ibuprofen arginine in the prior art Stability of Injection in Sodium Chloride Injection or Dextrose Injection or Sodium Lactated Ringer Injection

Method used

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  • Water-soluble ibuprofen pharmaceutical composition
  • Water-soluble ibuprofen pharmaceutical composition
  • Water-soluble ibuprofen pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] Take 500ml of water for injection, add arginine and ibuprofen, stir until dissolved, then add Tween 40, stir to dissolve and mix evenly, add 0.2% (2g / L) medicinal activated carbon, stir for 30min, filter to remove medicinal carbon, cooled to room temperature, then added water to 1 L, and finely filtered through a 0.22 μm microporous membrane to obtain a solution of the composition of the present invention with a concentration of 100 mg / mL.

[0025] The ibuprofen pharmaceutical composition solution is packaged in ampoules, sterilized at 121° C. for 15 minutes, packaged and then stored, and divided into 1000 bottles. In clinical use, it is diluted to the required concentration with physiological saline or glucose solution.

Embodiment 2

[0027]

[0028]

[0029] Take 2.5L of water for injection, add arginine and ibuprofen, stir until dissolved, then add Tween 60, stir to dissolve and mix evenly, add 0.2% medicinal activated carbon, stir for 30min, filter to remove medicinal carbon, and then continue Add water for injection to dilute to 5 L, fine filter with a 0.22 μm microporous membrane, and obtain the composition solution of the present invention. The concentration is 100mg / mL.

[0030] Injection was prepared according to the method of Example 1.

Embodiment 3

[0032]

[0033]Take 3L of water for injection, add arginine, ibuprofen, Tween 80, stir until dissolved, then add propylene glycol, stir to mix evenly, add 0.2% (2g / L) medicinal activated carbon, stir for 30min, filter to remove drug Dilute to 5 L with carbon, and then continue to add water for injection, fine filter with a 0.22 μm microporous membrane, and obtain the solution of the composition of the present invention. The concentration is 100mg / mL.

[0034] Injection was prepared according to the method of Example 1.

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Abstract

The invention discloses an ibuprofen pharmaceutical composition, comprising ibuprofen, arginine and tween. According to the invention, by adding tween in the ibuprofen and arginine solution, the stability of the ibuprofen pharmaceutical composition in clinic application is improved. Experiments show that the ibuprofen pharmaceutical composition solution can be stable for 48 hours after being diluted by using normal saline, glucose injection or Sodium Lactate Ringer's Injection.

Description

technical field [0001] The invention discloses a pharmaceutical composition of ibuprofen, which is a solution, specifically a pharmaceutical composition comprising ibuprofen, arginine and Tween, and belongs to the field of medicine. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory and analgesic drug commonly used in clinical practice. Its chemical name is 2-(4-isobutylphenyl)propionic acid. It has significant antipyretic, analgesic and anti-inflammatory effects. It mainly treats arthritis, Relieves various types of mild and moderate pains such as colds, dysmenorrhea, etc. The currently used ibuprofen is mainly a racemate. Existing studies have confirmed that S-ibuprofen has pharmacological activity in the human body, while R-ibuprofen is basically ineffective. After R-ibuprofen enters the human body, about 60 % converted to S-ibuprofen to have pharmacological activity. Since S-ibuprofen tastes better than racemic ibuprofen, it is gaining popular...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K31/198A61P29/00A61P31/00
Inventor 郝守祝张宝军
Owner 南通春秋软件科技有限公司
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