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Arginine ibuprofen oral disintegrating tablets and preparation method thereof

A technology of arginine ibuprofen and oral disintegrating tablets, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of poor patient tolerance and no arginine seen The related literature and patents of acid ibuprofen oral disintegrating tablets, pungent taste and other problems, to achieve the effect of easy packaging and transportation, easy industrial production, good hardness

Inactive Publication Date: 2013-03-06
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although syrups and granules can achieve quick effects, the problem is that they have a spicy taste and are poorly tolerated by patients, especially children's medication compliance is more obvious
[0006] Through the search, there are no relevant literature and patents related to ibuprofen arginine orally disintegrating tablets

Method used

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  • Arginine ibuprofen oral disintegrating tablets and preparation method thereof
  • Arginine ibuprofen oral disintegrating tablets and preparation method thereof
  • Arginine ibuprofen oral disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0020] Component Amount (g) Weight percent (%)

[0021] Arginine ibuprofen 185 37.0

[0022] Mannitol 197 41.6

[0023] Crospovidone 50 10.0

[0024] Aspartame 12 2.4

[0025] Povidone 2 0.4

[0026] Hypromellose 1 0.2

[0027] Eudragit E100 30 6.0

[0028] PEG 6000 3 0.2

[0029] Talc 15 1.2

[0030] Magnesium stearate 5 1.0

[0031] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0032] (1) The ethanol solution of povidone for arginine ibuprofen powder is made into a soft material, granulated through a 40-mesh sieve, and dried.

[0033] (2) The dry granules of (1) are sieved, placed in a fluidized bed bottom spray device, first coated with 1% hypromellose alcohol solution, after drying, then coated with Eudragit E100 alcohol solution (containing polyethylene g...

Embodiment 2

[0037] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0038] Component Amount (g) Weight percent (%)

[0039] Arginine ibuprofen 185 37.0

[0040] Mannitol 211 43.4

[0041] Crospovidone 40 8.0

[0042] Aspartame 12 2.4

[0043] Povidone 2 0.4

[0044] Hypromellose 1 0.2

[0045] Polyacrylic resin IV 30 6.0

[0046] PEG 6000 3 0.2

[0047] Talc 15 1.2

[0048]Micropowder silica gel 1 0.2

[0049] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0050] (1) Add arginine ibuprofen powder with ethanol solution of povidone to make a soft material, granulate through a 40-mesh sieve, and dry.

[0051] (2) the dry granules of (1) are sieved, put in the spraying device at the bottom of the fluidized bed, first use 1% hypromellose alcohol solution coating, after drying, then use the alcohol solution of polyacrylic resin IV ( ...

Embodiment 3

[0055] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0056] Component Amount (g) Component Percentage (%)

[0057] Arginine ibuprofen 185 37.0

[0058] Mannitol 202 40.2

[0059] Crospovidone 40 8.0

[0060] Aspartame 12 2.4

[0061] Hypromellose 1 0.2

[0062] Polyacrylic resin IV 20 4.0

[0063] Ethyl cellulose 10 2.0

[0064] Diethyl phthalate 1 0.2

[0065] Talc 12 2.4

[0066] Micronized silica gel 2 0.4

[0067] Fragrance 10 2.0

[0068] Magnesium stearate 5 1.0

[0069] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0070] (1) Make arginine ibuprofen powder and 1 / 3 amount of mannitol with water to make a soft material, granulate through a 40-mesh sieve, and dry.

[0071] (2) The dry granules of (1) are sieved, placed in a fluidized bed bottom spray device, coated with 2% hypromellose alcohol solution (tal...

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Abstract

The present invention relates to an orally disintegrating tablet of febrifuge and analgesic ibuprofen arginine and a preparing method thereof. The orally disintegrating of ibuprofen arginine according to the invention is composed of active component of ibuprofen arginine and appropriate medical supplementary material. The weight percent is as follows: 20%-60% of ibuprofen arginine, and 40%-80% of supplementary material. The supplementary material comprises the following components: one component or a plurality of components selected from thinning agent (filling agent), disintegrating agent, adhesive, wetting agent, lubricant, flavor correcting agent, colorant and effervescence disintegrating agent. The orally disintegrating of ibuprofen arginine can adopt the flavor correcting agent, mucilage, packing technique or integratedly use the plurality of methods for covering the biting taste of principal agent. The orally disintegrating of ibuprofen arginine of the invention has the advantages of excellent mouth feel, no requirement of water in medicine taking, quick disintegrating in oral cavity, quickly medicine releasing in stomach, guarantee of quick function, better hardness, no requirement of special device in production process and suitability of industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an orally disintegrating tablet of an antipyretic and analgesic arginine ibuprofen and a preparation method thereof. Background technique [0002] Orally disintegrating tablet is a new form of pharmaceutical preparation, which is a tablet that can disintegrate or dissolve in the oral cavity without water. It disintegrates quickly in the mouth, has no gritty feeling, has a good taste, is easy to swallow, and is non-irritating to the oral mucosa. [0003] The salient features of this dosage form: 1. Fast absorption and high bioavailability; 2. The method of administration does not require water, which is convenient for some people, such as the elderly, children, patients with difficulty swallowing or patients in special circumstances. [0004] Ibuprofen is an antipyretic and analgesic commonly used clinically, and its antipyretic and analgesic effect is remarkabl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K31/192A61K9/20A61K47/38A61P29/00
Inventor 王润玲杨金荣张庆伟
Owner TIANJIN MEDICAL UNIV
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