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Ibuprofen arginine tablet and preparation method thereof

A technology of arginine ibuprofen and tablets, which can be used in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve the problems of large amount of excipients, achieve rapid onset, high safety, and correct the effect of liver toxicity

Inactive Publication Date: 2013-04-24
HEFEI JINKE BIOPHARML TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defect that the amount of adjuvant in the existing arginine ibuprofen tablet is large, it is necessary to find a kind of arginine ibuprofen tablet with a small amount of adjuvant and is convenient for tabletting. The purpose of this invention is to provide a Arginine Ibuprofen Tablets

Method used

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  • Ibuprofen arginine tablet and preparation method thereof
  • Ibuprofen arginine tablet and preparation method thereof
  • Ibuprofen arginine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. For every 1000 arginine ibuprofen tablets, weigh the materials according to the following formula:

[0034] Arginine ibuprofen: 370.0g;

[0035] Crospovidone: 18.5g;

[0036] Gastric-soluble film coating premix: 16.3g;

[0037] Magnesium stearate: 4.0 g.

[0038] 2. The preparation process (such as figure 1 shown)

[0039] (1) Crush ibuprofen arginine and pass through a 80-mesh sieve, mix it with crospovidone in a tank mixer for about 30 minutes, then add an appropriate amount of purified water into the aforementioned tank mixer and stir for about 30 minutes Minutes to make soft materials.

[0040] (2) Pass the soft material through a 40-mesh sieve for oscillating granulation, dry the wet granules in a blast drying oven at 60°C, and pass the obtained dry granules through a 40-mesh sieve for granulation.

[0041] (3) Dissolve the gastric-soluble film coating premix in purified water, stir for about 45 minutes, and make a coating solution with a solid content of ...

Embodiment 2

[0044] 1. For every 1000 arginine ibuprofen tablets, weigh the materials according to the following formula:

[0045] Arginine ibuprofen: 370.0g;

[0046] Croscarmellose sodium: 14.3g;

[0047] Gastric-soluble film coating premix: 10.0g;

[0048] Magnesium stearate: 4.0 g.

[0049] 2. Preparation process

[0050] (1) Crush ibuprofen arginine and pass through 80 sieves, mix with croscarmellose sodium in a tank mixer for about 30 minutes, then add an appropriate amount of purified water into the aforementioned tank mixer and stir About 30 minutes to make soft materials.

[0051] (2) Pass the soft material through a 40-mesh sieve for oscillating granulation, dry the wet granules in a blast drying oven at 60°C, and pass the obtained dry granules through a 40-mesh sieve for granulation.

[0052] (3) Dissolve the gastric-soluble film coating premix in purified water, stir for about 45 minutes, and make a coating solution with a solid content of about 16wt% for later use, and pl...

Embodiment 3

[0055] 1. For every 1000 arginine ibuprofen tablets, weigh the materials according to the following formula:

[0056] Arginine ibuprofen: 370.0g;

[0057] Sodium carboxymethyl starch: 12.1g;

[0058] Hypromellose: 11.0g;

[0059] Micro silica gel: 2.4g;

[0060] Magnesium stearate: 1.2g.

[0061] 2. Preparation process

[0062] (1) Grind ibuprofen arginine and pass through 80 sieves, mix it with sodium carboxymethyl starch in a tank mixer for about 30 minutes, then add an appropriate amount of 5wt% ethanol aqueous solution into the aforementioned tank mixer and stir About 30 minutes to make soft materials.

[0063] (2) Pass the soft materials through 40 sieves for shaking granulation, dry the wet granules in a blast drying oven at 65°C, and pass the obtained dry granules through 40 sieves for granulation.

[0064] (3) Dissolve hypromellose in purified water and stir for about 30 minutes to make a coating solution with a solid content of about 12wt% for later use. Put the...

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Abstract

The invention relates to an ibuprofen arginine tablet which comprises, by weight, 90.01 to 99.00% of ibuprofen arginine, with the balance being adjuvant. The invention further relates to a preparation method for the ibuprofen arginine tablet. In the tablet provided by the invention, the content of ibuprofen arginine is greater than 90%, and a small amount of the adjuvant is contained; the tablet has better stability and higher security; after granulation, the tablet undergoes coating, so a better taste masking effect is obtained, and an obtained granule has better fluidity and smaller hygroscopicity. The preparation method provided by the invention has the advantages of a simple process, a short production period, high efficiency, more effective conservation of production cost and suitability for large scale industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an arginine ibuprofen tablet and a preparation method thereof. Background technique [0002] Ibuprofen is a commonly used non-steroidal anti-inflammatory and analgesic drug in clinic, and its analgesic effect is remarkable. Ibuprofen is almost insoluble in water, the pharmacokinetic parameter T of its tablet max The value (time to reach maximum blood concentration) is 1.5-2 hours, and the onset of action is relatively slow. Arginine ibuprofen is the arginine salt of ibuprofen, which is a water-soluble derivative. The reported dosage forms include syrup and granules 2, all of which are water-soluble quick-acting preparations, which increase the absorption rate in the body. But although syrup and granule can achieve quick effect, the problem of existence is that taste is pungent, and patient tolerance is poor. And the production and storage takes up a lot of space, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/32A61K9/36A61K31/205A61K31/192A61P29/00
Inventor 耿燕王雯俞林龙余丹丹李芳芳
Owner HEFEI JINKE BIOPHARML TECH
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