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Medicine compound containing ibuprofen arginine and preparation method thereof

A technology of arginine ibuprofen and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve problems such as high production cost and irritating odor of arginine ibuprofen granules , to achieve the effects of low production cost, ensuring drug safety, and simple components

Active Publication Date: 2017-10-10
HAIHE PHARMA WENZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a kind of arginine ibuprofen granule with low production cost, high safety and good drug compliance of patients and its preparation method, which overcomes the problem of arginine ibuprofen granule in the prior art. It has defects such as pungent smell, high production cost, and hidden dangers of drug safety

Method used

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  • Medicine compound containing ibuprofen arginine and preparation method thereof
  • Medicine compound containing ibuprofen arginine and preparation method thereof
  • Medicine compound containing ibuprofen arginine and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A pharmaceutical composition containing arginine ibuprofen, comprising the following components in parts by weight:

[0030]

[0031]

[0032] The preparation method of the above-mentioned pharmaceutical composition containing arginine ibuprofen, comprises the steps:

[0033] 1) Take stearic acid and heat it to melt, and the temperature is controlled at 60°C;

[0034] 2) Add ibuprofen arginine to the stearic acid molten liquid, and stir well;

[0035] 3) Spray drying, the sample temperature is controlled at 70°C, the air temperature is controlled at 20°C, and the obtained particles are passed through a 60-mesh sieve;

[0036] 4) Take sucrose, pass through a 60-mesh sieve, mix with the above-mentioned granules, and pass through a 40-mesh sieve to mix;

[0037] 5) Take purified water as a wetting agent, and pass through a 60-mesh sieve to make soft materials;

[0038] 6) Take the above soft material and dry it at 60°C for 1 hour;

[0039] 7) Sieve through a 40-m...

Embodiment 2

[0041] A pharmaceutical composition containing arginine ibuprofen, comprising the following components in parts by weight:

[0042] Arginine ibuprofen

1 copy

sucrose

0.5 parts

stearic acid

0.5 parts

purified water

0.05 parts

[0043] The preparation method of the above-mentioned pharmaceutical composition containing arginine ibuprofen, comprises the steps:

[0044] 1) Take stearic acid and heat it to melt, and the temperature is controlled at 100°C;

[0045] 2) Add ibuprofen arginine to the stearic acid molten liquid, and stir well;

[0046] 3) Spray drying, the sample temperature is controlled at 95°C, the air temperature is controlled at 40°C, and the obtained particles are passed through a 100-mesh sieve;

[0047] 4) Take sucrose, pass through a 100-mesh sieve, mix with the above-mentioned granules, and pass through a 40-mesh sieve to mix;

[0048] 5) Take purified water as a wetting agent, and pass through a 60-mesh siev...

Embodiment 3

[0052] A pharmaceutical composition containing arginine ibuprofen, comprising the following components in parts by weight:

[0053] Arginine ibuprofen

[0054] The preparation method of the above-mentioned arginine-containing ibuprofen-containing pharmaceutical composition is the same as in Example 1.

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Abstract

The invention discloses a medicine compound containing ibuprofen arginine and a preparation method thereof. The medicine compound containing ibuprofen arginine comprises the following components in parts by weight: 1 part of ibuprofen arginine, 0.5-50 parts of saccharose, 0.5-50 parts of stearic acid and 0.05-5 parts of purified water. The medicine compound containing ibuprofen arginine according to the invention has simple components, includes two accessories of saccharose and stearic acid except for ibuprofen arginine, not only can effectively solve the problem of pungent smell of ibuprofen arginine and tastes nice, but also is low in production cost. Besides, the medicine compound containing ibuprofen arginine provided by the invention adopts water as a wetting agent, not only has the problem of ethyl alcohol residue, but also guarantees the medication safety of the patient suffering from alcohol allergy.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing arginine ibuprofen and a preparation method thereof. Background technique [0002] Ibuprofen Arginine is a non-steroidal anti-inflammatory drug, which can inhibit the synthesis of prostaglandins and has analgesic, anti-inflammatory and antipyretic effects. The chemical name of arginine ibuprofen is 2-(4-isobutylphenyl)propionic acid-L-arginine salt, the molecular formula is C19H32N4O4, and the molecular weight is 380.48. Arginine ibuprofen granules were developed by Zambon S.P.A, Italy, and are mainly used for toothache, dysmenorrhea, pain caused by trauma such as sports injuries, joint and ligament pain, back pain, headache, and fever caused by influenza. Because its active ingredient is ibuprofen arginine salt, the solubility of ibuprofen is greatly improved, and the absorption rate is faster than that of ibuprofen. The pain re...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/26A61K47/12A61K31/192A61P29/00
CPCA61K9/1617A61K9/1623A61K31/192
Inventor 李淑君张金成司成桃
Owner HAIHE PHARMA WENZHOU
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