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103 results about "Hydroxy derivative" patented technology

Hydroxy Derivatives. When one or more hydrogen atoms of a hydrocarbon are replaced by an equal number of hydroxyl groups (−OH group), the compound is called a hydroxy derivative.

Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom

A process for manufacturing an α-dihydroxy derivative from an aryl allyl ether wherein such α-dihydroxy derivative can be used to prepare an α-halohydrin intermediate and an epoxy resin prepared therefrom including epoxidizing an α-halohydrin intermediate produced from a halide substitution of an α-dihydroxy derivative which has been obtained by a dihydroxylation reaction of an aryl allyl ether in the presence of an oxidant or in the presence of an oxidant and a catalyst.
Owner:DOW GLOBAL TECH LLC

Polyglycol block modified polyhexanolactone and its preparing method

The present invention discloses a kind of amphiphilic BAB-type block copolymer with polyglycol blocks at two ends and polyhexanolactone section in the middle part and its preparation process and application. It is prepared with diisocyanate as cross-linking agent polyglycol or other single- or double-hydroxy derivative and polycaprolactone glycol as material. The copolymer can self-assemble in water into nanometer particle or micelle with shell of hydrophobic polydexanolactone section and shell of hydrophilic polyglycol. It has excellent coating capacity to hydrophobic medicine and thus may be used in preparing water soluble nanometer particle or micelle of hydrophobic medicine.
Owner:TIANJIN UNIV

Use of novel lipid mediators to inhibit angiogenesis

The present invention is generally drawn to novel isolated therapeutic agents, termed lipoxins, generated from the interaction between a dietary omega-6 polyunsaturated fatty acid (PUFA) such as arachidonic acid (AA), oxygenases and the analgesic aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy containing derivatives of AA containing compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- and tri-hydroxy derivatives of AA (lipoxins, aspirin-triggered epi-lipoxins) that diminish, prevent, or eliminate NV, hemangiogenesis and / or angiogenic condition(s) of corneal tissue. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
Owner:THE SCHEPENS EYE RES INST +1

Process for the preparation of phenol and cyclohexanone

Process for the preparation of phenol and cyclohexanone which comprises:a. the synthesis of cyclohexylbenzene by the hydro-alkylation of benzene by contact with hydrogen or the alkylation of benzene with cyclohexene using Y zeolites;b. the selective aerobic oxidation of cyclohexylbenzene to the corresponding hydroperoxide catalyzed by N-hydroxy-derivatives in the presence of polar solvents; andc. the scission of the hydroperoxide of cyclohexylbenzene to phenol and cyclohexanone by homogeneous or heterogeneous acid catalysts;characterized in that the synthesis of cyclohexylbenzene takes place in the presence of a catalytic system comprising a Y zeolite and an inorganic ligand wherein the Y zeolite has a crystalline structure with openings consisting of 12 tetrahedra and the inorganic ligand is γ-alumina, and wherein said catalytic composition is characterized by a pore volume, obtained by adding the mesoporosity and macroporosity fractions, greater than or equal to 0.7 cm3 / g, wherein at least 30% of said volume consists of pores with a diameter greater than 100 nanometers.
Owner:POLIMERI EUROPA SPA

N-demethylation of N-methyl morphinans

The present invention provides a synthetic process for the N-demethylation of N-methyl morphinans. In particular, the invention provides improved synthetic methods for the preparation of N-demethylated morphinan compounds that may be employed as starting materials, for example, commonly available N-methyl opiates such as oripavine and thebaine, and C(3)-protected hydroxy derivatives of oripavine.
Owner:SPECGX LLC

Cyclopentane 1-hydroxy alkyl or alkenyl-2-one or 2-hydroxy derivatives as therapeutic agents

The present invention provides a novel compound represented by the general formula I;wherein R is H or COR3;R1 is H, R2, phenyl, or COR3, wherein R2 is C1-C5 lower alkyl and R3 is R2 or phenyl;Z is CH2 or O;Y is OH or OCOR3;x is 0 or 1; andX is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR42, CO2R4 and OR4 wherein R4 is hydrogen or C1-C5 alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.
Owner:ALLERGAN INC

Process for Production of Fluoro Derivative

It was found that a fluoro derivative can be produced by reacting a hydroxy derivative with sulfuryl fluoride (SO2F2) in the presence of an organic base or in the presence of an organic base and “a salt or complex comprising an organic base and hydrogen fluoride”. According to the present production process, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in industrial use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, specifically 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and the like, even in a large scale.
Owner:CENT GLASS CO LTD

Industrial process for the production of L-carnitine

The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controlled conditions of hydrogen pressure, substrate concentration, temperature, and substrate: catalyst molar ratio, enables 4-chloro-3-hydoxybutyrate or 4-chloro-hydroxybutyamide to be obtained in a high yield. The process described, which leads to L-carnitine being obtained, is easily applicable on an industrial scale.
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA

Special-purpose softening agent for papermaking

The invention provides a softening agent for papermaking. The softening agent for papermaking is prepared from imidazolium quaternary, nonionic surface active agents, phosphate ester and polyhydroxy derivatives, wherein the mass ratio of the imidazolium quaternary to the nonionic surface active agents to the phosphate ester to the polyhydroxy derivative is (1-20):(20-90):(5-15):(1-20). Through the adoption of the softening agent disclosed by the invention, not only the softness of paper can be improved, but also the hardness and the hygroscopicity of the paper are not influenced, and at the same time, the softening agent has the functions of withstanding bacteria and corrosion inhibition. The softening agent can be widely used for papermaking industry.
Owner:WEIHAI XIANGYU TECH

N-demethylation of N-methyl morphinans

The present invention provides a synthetic process for the N-demethylation of N-methyl morphinans. In particular, the invention provides improved synthetic methods for the preparation of N-demethylated morphinan compounds that may be employed as starting materials, for example, commonly available N-methyl opiates such as oripavine and thebaine, and C(3)-protected hydroxy derivatives of oripavine.
Owner:SPECGX LLC

Process for production of fluoro derivative

It was found that a fluoro derivative can be produced by reacting a hydroxy derivative with sulfuryl fluoride (SO2F2) in the presence of an organic base or in the presence of an organic base and “a salt or complex comprising an organic base and hydrogen fluoride”. According to the present production process, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in industrial use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, specifically 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and the like, even in a large scale.
Owner:CENT GLASS CO LTD

Use of a resveratrol derivative for skin whitening

The present invention relates to a use of a resveratrol derivative for skin whitening, and more specifically, to: a cosmetic composition containing an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a cosmetically acceptable salt thereof as an active ingredient; a cosmetic product containing the cosmetic composition; a skin whitening pharmaceutical composition containing an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient; a skin preparation for external use, containing the skin whitening pharmaceutical composition; a skin whitening method in which an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a pharmaceutically acceptable salt thereof is administered to an individual; and a novel resveratrol derivative compound having a skin whitening effect.
Owner:国立庆北大学校产学协力团

Method for preparing capecitabine and hydroxyl derivative intermediate thereof

The invention discloses a method for preparing an anticancer medicine capecitabine and a hydroxyl derivative key intermediate thereof, and belongs to the technical field of pharmaceutical chemistry. The method is characterized in that: N-[(p-pentyloxy)carbonyl]-5-flurocytosin is taken as an initial raw material, and is subjected to five steps of chemical reactions to form the capecitabine. The preparation method has the advantages of reasonable sequence, readily available raw materials, mild reaction conditions, high process controllability, high yield and low cost. The crude intermediate has high purity, complicated purification treatment is avoided, the capecitabine obtained in a later stage can reach the standard of United States Pharmacopeia, and the method is more suitable for industrial production.
Owner:JIANGNAN UNIV

Benzene sulfonamide hydroxyl derivative and intermediate thereof as well as preparation method and application thereof

The invention discloses a benzene sulfonic amide hydroxyl derivative as shown in a formula 5 and a preparation method thereof as well as the application of a compound 5 of F as a PET imaging molecular probe. The compound has favorable suppressive activity of carbonic anhydrase, stronger hydrophilicity and little collection and little nonspecific absorption in a digestive system of a human body. The preparation method of the compound adopts simply and easily obtained raw materials and simple preparation method and has no particular requirements for high-temperature, high-pressure or sensitive reagents. The invention also discloses a intermediate compound as shown in a formula 4 used in the preparation method of the compound and the preparation method thereof.
Owner:SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI

Preparation method of self-assembled superlattice materials of titanium dioxide nano rod

InactiveCN101618891AEasy self-assembly behaviorMixing methodsTitanium dioxideSurface-active agentsSolvent
The invention discloses a preparation method of self-assembled superlattice materials of a titanium dioxide nano rod, comprising the following steps: (1) monodispersed TiO2 nano rods are synthetized, and the synthetic reaction is based on a condition that an unstable hydroxy derivative is produced by oleic acid titanium under nucleophillic attack of oil amide, the hydroxy derivative can be further polymerized to generate Ti-o-Ti, and produced TiO2 nano sticks are dispersed to a non-polar solvent to make clear TiO2 solution; (2) superfluous oil acid surface activators are added into the solution, and the superlattice materials with different structures (riband shapes and beehive shapes) are made by controlling the concentration of the oil acid in the solution and evaporating slow solvents. The invention has the advantages of firstly expanding the preparation scope of one-dimensional superlattice materials to the TiO2 nano rods of anatase, utilizing superfluous oil acid surface active agent to lead depletion attraction to adjacent TiO2 nano sticks, thereby adding macro-control factors for self-assembled drive force of the nano sticks so as to enable the self-assembled behavior to be easily generated.
Owner:ZHEJIANG UNIV

Industrial process for the production of L-carnitine

The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controlled conditions of hydrogen pressure, substrate concentration, temperature, and substrate: catalyst molar ratio, enables 4-chloro-3-hydoxybutyrate or 4-chloro-hydroxybutyamide to be obtained in a high yield. The process described, which leads to L-carnitine being obtained, is easily applicable on an industrial scale.
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA

Stabilized liquid enzyme composition

The present invention relates to a liquid composition comprising an enzyme and an enzyme stabilizer of the following formula:or a salt thereof, wherein R1 is selected from the group consisting of C0-C5 alkyl, substituted C1-C5 alkyl, C1-C5 alkenyl and substituted C1-C6 akenyl and R2, R3, R4, R5 and R6 is selected from the group consisting of hydrogen, C1-C6 alkyl, substituted C1 to C6 alkyl, aryl, substituted aryl, hydroxyl, hydroxyl derivative, amine, C1-C6 alkylated amine, amine derivative, halogen, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate.
Owner:NOVOZYMES AS

Enantiomers of 2-hydroxy derivatives of fatty acids

This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [−] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis / prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.
Owner:UNIV DE LAS ISLAS BALEARES

Cyclopentane, 1-hydroxy alkyl or alkenyl-2-one or 2-hydroxy derivatives as therapeutic agents

The present invention provides a novel compound represented by the general formula I:wherein R is H or COR3;R1 is H, R2, phenyl, or COR3, wherein R2 is C1-C5 lower alkyl and R3 is R2 or phenyl;Z is CH2 or O;Y is OH, OCOR3 or =O;x is 0 or 1; andX is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR42, CO2R4 and OR4 wherein R4 is hydrogen or C1-C5 alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.
Owner:ALLERGAN INC

Preparations and applications of dialkyl dithiocarbamate hydroxy derivative and borate thereof

The invention relates to preparations of dialkyl dithiocarbamate hydroxy derivative (I) and borate (II) of the dialkyl dithiocarbamate hydroxy derivative, both of which can be used as environment-friendly lubricant additives, can effectively improve the antifriction performance of environment-friendly base oils, and play an antiwear role. The preparation method comprises the following steps of: reacting secondary amine and carbon disulfide to generate dialkyl dithiocarbamate in the presence of an acid-binding agent, then reacting with propylene oxide to obtain the hydroxy derivative containing a dialkyl dithiocarbamate functional group; and reacting the latter and borate according to an appropriate stoichiometric ratio so as to generate the borate. The method is simple in process, mild in conditions, and suitable for industrial production.
Owner:PETROCHINA CO LTD

Application of bilobalide as synergist in preparation of drug for preventing cranial nerve injury diseases

The present invention discloses application of bilobalide as a synergist in preparation of a drug or a heath product for preventing cranial nerve injury diseases. An inventor discovers that compounds of bilobalides, particularly bilobalide, bilobalide extracts, and hydroxyl derivatives of bilobalides, particularly glucoside derivatives, ester derivatives and ether derivatives can well promote drug molecules with a treating or health care function on cranial nerve injury diseases to enter brain tissues, wherein the drug molecules comprise ginsenoside, stibene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam and the like; under the conditions of not increasing drug concentration in blood, the concentration of bilobalide can be increased to a large extent in the brain tissues, so that the efficacy of the drug can be improved, and side effects and adverse reactions of the drug can be reduced.
Owner:GUANGDONG PHARMA UNIV

Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate

The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.
Owner:METABOLIC EXPLORER

Use of C60 polyhydroxy derivates in preventing and treating related disease of mitochondria damage

The invention belongs to the biological and medical field and discloses an application of a C60 or C60 polyhydroxy derivative in preparing a combination for preventing and remedying the related diseases of mitochondrial injury (such as neurodegenerative disease or radiation sickness). The invention constructs a cellular model and an animal model with the related diseases of the mitochondrial injury, demonstrates the excellent efficacy of the C60 or C60 polyhydroxy derivative for preventing and remedying the related diseases of the mitochondrial injury and provides an effective approach for developing multifunctional drugs with mitochondria as a target point accordingly.
Owner:SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI +1

Method for synthesizing alcoholic hydroxyl fluorine derivatives

The invention discloses a method for synthesizing alcoholic hydroxyl group fluoro derivatives, which belongs to the technical field of chemosynthesis. In the presence of organic amine and organic solvent, PBSF and TBAT are jointly used as fluorination reagents and subjected to fluorination with hydroxyl derivatives, so as to obtain the alcoholic hydroxyl group fluoro derivatives. The synthesis method has the advantages of greatly reducing and eliminating byproducts, reducing the amount of the TBAT to an equivalent below 1.2, completely inverting the configuration of the fluorination of chiral alcoholic hydroxyl under mild conditions and reducing optical isomer impurities.
Owner:FUJIAN INST OF MICROBIOLOGY

Preparation method of 7-ketone sterides

The invention discloses a preparation method of 7-ketone sterides. The preparation method comprises the following steps: 1, firstly, dissolving steroids and an N-hydroxyl derivative as a catalyst in a solvent, then adding an oxidizing agent to generate an allylic oxidation reaction at a temperature of 0-60 DEG C, after the sterides are completely oxidized, ending the reaction, wherein the mol ratio of the sterides to the N-hydroxyl derivative as the catalyst is 1:(0.1-10), and the mol ratio of the sterides to the oxidizing agent is 1:(2-10); 2, drying a solvent in a reaction solution obtained in the step 1 by distillation, and then recovering the N-hydroxyl derivative as the catalyst through normal hexane to obtain the 7-ketone sterides.
Owner:ZHEJIANG UNIV

Composition of sequestrant for application to the elimination and/or reduction of hydrogen sulfide and/or mercaptans in fluid

The invention discloses a sequestrant composition for application to the elimination and / or reduction of hydrogen sulfide and / or mercaptans in fluid, particularly the reduction or elimination of hydrogen sulfide from gases and liquids, including gaseous and liquid hydrocarbons, and sewage gases, especially from natural gas and liquid hydrocarbon streams. The composition uses a main scavenger agent and sequestration rate accelerator additive that also acts as a precipitation prevention agent. The use of the composition is described as being the main scavenger agent for a 1,3-dioxolane alkyl, alkenyl and / or hydroxyl derivative and ketone-based accelerator additives that include α-diketones and cyclic ketones, saturated and / or α-unsaturated.
Owner:OXITENO S A IND E COMERCIO
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