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30 results about "Gene map" patented technology

Gene maps help describe the spatial arrangement of genes on a chromosome. Genes are designated to a specific location on a chromosome known as the locus and can be used as molecular markers to find the distance between other genes on a chromosome. Maps provide researchers with the opportunity to predict the inheritance patterns of specific traits, which can eventually lead to a better understanding of disease-linked traits.

Genemap of the human genes associated with longevity

InactiveUS20090305900A1Electrolysis componentsVolume/mass flow measurementGenomicsLinkage Disequilibrium Mapping
The present invention relates to the selection of a set of SNP markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's longevity, their protection against age-related diseases and / or their response to a particular drug or drugs.
Owner:BELOUCHI ABDELMAJID +12

Genemap of the human genes associated with crohn's disease

InactiveUS20090081658A1Reduce frequencyTreatment safetyMicrobiological testing/measurementGenomicsLinkage Disequilibrium Mapping
The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and / or their response to a particular drug or drugs.
Owner:GENIZON BIOSCI

Method for preparing and using personal and genetic profiles

Method and system for preparing a personal genetic profile includes collecting genetic data from an individual, assigning the data to a coordinate system, storing the data, and providing access for retrieval by the individual from whom the genetic data were collected, after receipt of an Identifier that adequately authenticates the identity of the data requestor. Locations of genetic markers are provided as three-dimensional coordinates, described with matrix relationships that are consistent with the primary and secondary chemical structure of molecular constituents of a DNA chain for the individual.
Owner:RATHJEN ALICEMARIE G +9

Genemap of the human genes associated with psoriasis

The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to psoriasis disease and / or their response to a particular drug or drugs.
Owner:GENIZON BIOSCI

Selection of embryo of test tube baby through sequencing by single cell genome of polar body or embryo

Disclosed is a method for using a first polar body and a second polar body as well as a single-cell embryo to carry out whole-genome non-exponential amplification and high-throughput genome sequencing, so as to perform preimplantation genetic diagnosis for genetic disease and testing for pathogenic genes causing repeated miscarriages. The method of the present invention comprises the following steps: (1) obtaining oocytes and embryos, and carrying out separation and genome amplification of first and second polar bodies and single-cell embryos; (2) establishing a genome sequencing library and sequencing, and carrying out bioinformatic analysis of the genome to obtain a gene spectrum and information concerning the number of copies of chromosomes and fragments thereof; (3) determining the chromosome ploidy of the polar bodies and embryos as well as information concerning defects, replication and point mutation in the chromosome fragments; (4) selecting normal or suitable embryos for implantation.
Owner:HARVARD UNIV +2

Genemap of the human genes associated with adhd

The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to ADHD disease and / or their response to a particular drug or drugs.
Owner:GENIZON BIOSCI

Genemap of the human genes associated with crohn's disease

The present invention relates to the selection of a set of polymorphism makers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to IBD (ex: Chrohn's disease) and / or their response to a particular drug or drugs.
Owner:BELOUCHI ABDELMAJID +12

Gene image processing estimation method, system, medium and equipment based on deep learning

The invention discloses a gene image processing method, system, medium and equipment based on deep learning, and the method comprises the steps: obtaining an original image, and building and marking the original image as a sample set; dividing the sample set into a training sample and a test sample, obtaining and extracting a pre-selected model, and obtaining an image prediction model according tothe transfer learning training sample; calculating the test sample according to the image model to obtain a prediction calculation result; and obtaining an actual monitoring result, comparing the actual monitoring result with the prediction calculation result to obtain index calculation information, and calculating performance index data according to the index calculation information. The technical problems that in the prior art, too many noise pictures exist, the model performance is poor, and the picture marking effect is poor are solved.
Owner:SHANGHAI JIAO TONG UNIV

Process for clone gene of virus host factor

A method for cloning the virus host factor gene by use of dual-chain RNA low-poison virus (chesnut blight bacterium system) includes such steps as light irradiating to induce the generation of conidia of chestnut phytophthora disease bacteria, inducing to obtain mutant, purifying, discriminating the virus carried by said mutant, testing the activity of its mRNA precursor, transforming and complementing of said mutant, discriminating, sequentially the exogenous DN'A fragment of the transformed plasmid with complem entary power, and configuring gene map.
Owner:GUANGXI UNIV

Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes

Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.
Owner:UNITED STATES OF AMERICA

Image analysis system and method of biochip

Disclosed is a biochip image analysis system which comprises an image storage unit for storing images including an original image of a biochip comprising a set of specific genes expressed in different environments by fluorescent bases of different colors; an image converter for converting the original image into a test image, forming an overlapped image and a color image, and storing the images in the image storage unit; an edge detector for separating the spot-formed genes from the test image, generating spot and background templates, and detecting an edge to measure expression degrees of the genes; a data processor for generating statistical data using the spot and background templates, and performing luminance correction; and a data storage unit for storing the statistical data.
Owner:IUCF HYU (IND UNIV COOP FOUNDATION HANYANG UNIV)

Application of group of genes related to prognosis of colon cancer

The present invention evaluates clinical prognosis of patients with colon cancer based on discovery of a group of 15 prognosis-related gene maps and a detection of expression levels of the group of the 15 prognosis-related gene maps in clinical tumor samples and according to prognosis correlation coefficients of these specific genes to calculate prognosis scores of the patients, and discloses a related application. The prognostic and predictive power of the system is twice that of the Oncotype DX (Genomic Health company) scoring system which is the only clinical application in the United States currently. According to the system and different detection technology platforms, corresponding 15 gene expression measurement kits are designed and developed. The system and product can assist in evaluating response of the patients with the colon cancer to therapeutic interventions to determine whether the patients benefit from chemical or targeted therapies for precise treatment based on individualized risks.
Owner:BERKELEY NANJING MEDICAL RES CO LTD +1

Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes

Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift.
Owner:UNITED STATES OF AMERICA

KASP mark for detecting powdery mildew resistant gene of aegilops tauschii and application

The invention relates to the field of wheat genetics and molecular breeding thereof, in particular to development and application of a function mark of a powdery mildew resistant gene of aegilops tauschii. On the basis that the powdery mildew resistant gene M12147 of aegilops tauschii is subjected to map position clone, special structure sequences of candidate genes are used, a function mark SDAU-kasp2147 is developed, and verification is conducted by using 180 or more parts of aegilops tauschii natural germplasm and genetic offspring materials. The result proves that the function mark has theadvantage that the function mark is quick, direct and high in flux, is high in specificity, can complete screening and phenotype prediction work of the disease-resistant gene in mass materials in a short time, and can effectively serve for breeding work of wheat powdery mildew resistance.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes

Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.
Owner:US DEPT OF HEALTH & HUMAN SERVICES

Binary code tracing method for multi-granularity information fusion under software gene perspective

The invention belongs to the technical field of network security, and discloses a binary code tracing method for multi-granularity information fusion under a software gene perspective, which comprises the following steps of: 1, extracting a software gene sequence, a software gene and a software gene map of a target program and common information which can be directly extracted from IDA to an sqlite database; 2, carrying out word embedding on the software gene sequence in the sqlite database, and then carrying out bidirectional GRU model training to obtain a feature vector; 3, performing multi-granularity sequence information fusion based on the feature vector obtained after training in the step 2 and information in the sqlite database to obtain a feature vector containing multi-granularity information, and then performing structured learning through graph convolution; 4, mapping the learned hidden layer space feature vector representation to a sample marking space through a full connection layer to serve as a voting value of judgment, and finally obtaining a classification result. The method has high binary code traceability accuracy.
Owner:PLA STRATEGIC SUPPORT FORCE INFORMATION ENG UNIV PLA SSF IEU

New method for accurately estimating physical and mechanical parameters of geotechnical material

The invention provides a new method for accurately estimating physical and mechanical parameters of a geotechnical material, which comprises the following steps: acquiring prior gene characteristics: acquiring historical big data of physical and mechanical parameters of geotechnical materials in different areas and different groups, and performing statistical analysis according to the historical big data to obtain prior gene characteristics; carrying out posterior gene feature establishment: carrying out statistical analysis on physical and mechanical parameter test values of the newly added geotechnical material obtained in specific engineering detection to obtain posterior gene features; and accurately estimating the values of the mechanical parameters of the geotechnical material, namely accurately estimating the values of the corresponding parameters by using a Bayesian estimation method based on the prior gene characteristics and the posterior gene characteristics. According to the method, by means of the biological concept, the two concepts of the gene feature and the gene map of the geotechnical material for describing the overall physical and mechanical characteristics of the specific geotechnical material in a certain space range are put forward for the first time, and the prior gene feature and the posterior gene feature are combined; and the Bayesian estimation theory is used for rapidly and accurately estimating the geotechnical material parameters, so that the parameter estimation efficiency and precision are improved.
Owner:王艳磊

Screening method of rice SNP sites and method for identifying rice varieties

The invention discloses a screening method of rice SNP (Single Nucleotide Polymorphism) sites and a method for identifying rice varieties, and relates to the technical field of biomolecules. Before the SNP sites for identifying the rice varieties are screened, rice samples used for obtaining the SNP sites are filtered, non-core population samples are filtered out, then the SNP sites are screened and detected, therefore, the pertinence and effectiveness of the SNP site on identification and analysis of specific rice varieties can be remarkably improved, and a way is provided for effective identification of the specific rice varieties and construction of a rice high-quality heterogeneity gene map.
Owner:SOUTH CHINA AGRI UNIV +1

Modularized assembly and overall parameter rapid generation method of equipment model

PendingCN114329928ASolving Modular Assembly ProblemsModeling method is friendlyDesign optimisation/simulationManufacturing computing systemsAlgorithmModelSim
A modular assembly and overall parameter rapid generation method of an equipment model is characterized in that on the basis of a class gene map representation recombination technology and a modularization theory, under the condition that a battlefield environment is complex and battlefield tasks are variable, equipment multi-source gene recombination data fitting is carried out through building block modular equipment modeling and construction of a maximum likelihood model; the modular assembly and overall parameter rapid generation method of the equipment model is established, the problems that a traditional modeling method is poor in reusability, modules are not universal, and the modeling method is difficult to adapt to rapid upgrading and updating of the equipment are solved, and the modeling method is more friendly and more flexible.
Owner:CHINA ACAD OF LAUNCH VEHICLE TECH

A method for constructing regulatory networks of differentially expressed genes in specific cancers

The invention discloses a construction method for a specific cancer differential expression gene regulation and control network.The method includes the following steps of firstly, constructing a framework gene interaction network according to function similarity weight numbers between genes; secondly, conducting module division on the framework gene interaction network through a segmenting method; thirdly, screening out differential expression genes through complete genome methylation data; fourthly, classifying the screened-out differential expression genes according to functions; fifthly, using all the differential expression genes mapped to each same function module as a function classification; sixthly, constructing the regulation and control network of all the genes in each function classification function; seventhly, conducting sub-network splicing under guidance of a framework network.The calculation complexity is greatly reduced, and high precision is achieved.
Owner:JILIN UNIV

Gene sequence storage and restoration method, computer storage medium and electronic equipment

The invention provides a method for storing and restoring a gene sequence, a computer storage medium and an electronic device. The method for storing and restoring a gene sequence includes the following steps: S1, uploading the gene sequence, and setting a restoration password; S2, setting the The gene sequence of the recovery password is stored as a gene picture in picture format, and a positioning code is added during the storage process; S3, uploading the gene picture, and searching for the positioning code from the gene picture to determine the The starting position and reading direction of the gene sequence recorded in the gene picture; S4, input the password, and judge whether the password matches the restored password; S5, when the password matches the restored password, set The gene picture is restored to the gene sequence. The method for storing and restoring gene sequences according to the embodiments of the present invention can effectively reduce the trial-and-error time when gene pictures are restored to gene sequences, improve the efficiency of gene sequence restoration, and improve user experience.
Owner:YUNZHOU BIOSCIENCES (GUANGZHOU) INC

Gene sequence storage and restoration method, computer storage medium and electronic equipment

The invention provides a gene sequence storage and restoration method, a computer storage medium and electronic equipment, and the gene sequence storage and restoration method comprises the following steps: S1, uploading a gene sequence, and setting a restoration password; S2, storing the gene sequence set with the reduction password as a gene picture in a picture format, and adding a positioning code in the storage process; S3, uploading the gene picture, and searching the positioning code from the gene picture to determine an initial position and a reading direction of a gene sequence recorded by the gene picture; S4, inputting a password, and judging whether the password is matched with the restored password or not; and S5, when the password is matched with the reduction password, reducing the gene picture into the gene sequence. According to the gene sequence storage and reduction method provided by the embodiment of the invention, the trial and error time when the gene picture is reduced into the gene sequence can be effectively shortened, the gene sequence reduction efficiency is improved, and the user experience is improved.
Owner:YUNZHOU BIOSCIENCES (GUANGZHOU) INC

A kind of kasp marker and its application to detect the powdery mildew resistance gene of Goatweed

The invention relates to the field of wheat genetics and molecular breeding thereof, in particular to development and application of a function mark of a powdery mildew resistant gene of aegilops tauschii. On the basis that the powdery mildew resistant gene M12147 of aegilops tauschii is subjected to map position clone, special structure sequences of candidate genes are used, a function mark SDAU-kasp2147 is developed, and verification is conducted by using 180 or more parts of aegilops tauschii natural germplasm and genetic offspring materials. The result proves that the function mark has theadvantage that the function mark is quick, direct and high in flux, is high in specificity, can complete screening and phenotype prediction work of the disease-resistant gene in mass materials in a short time, and can effectively serve for breeding work of wheat powdery mildew resistance.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

DNA encoding the human serine protease T

Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T mRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological / neurodegenerative and / or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.
Owner:ORTHO MCNEIL PHARM INC

A method for rapid and fine mapping of rice genes

ActiveCN106191301BHigh quality high densityIncrease exchange rateMicrobiological testing/measurementRandom populationConfidence interval
The invention relates to a technological method for rapidly and finely positioning rice germplasm resource genes. The method mainly comprises the following steps: (1) selecting a rice variety with wide hereditary variation as a donor, and carrying out hybridization and backcrossing on the rice variety with the same recurrent parent respectively; selecting target traits including high yield, drought control, salt resistance and the like from a random population of a backcrossing introgressive line, so as to obtain a selected introgressive line population with the target traits; (2) carrying out non-target trait phenotype inspection on the multi-parent selected introgressive line population; positioning QTL (Quantitative Trait Locus) influencing non-target traits by utilizing a gene type and a phenotype, which are obtained by high-throughput sequencing, through genome-wide association analysis; (3) identifying a recombinant strain in a QTL confidence interval by adopting a high-density SNP (Single Nucleotide Polymorphism) gene type, and selectively inducing the recombinant strain with low frequency and combining a phenotype value to further finely position a QTL. The method is suitable for carrying out quantity trait QTL positioning and fine positioning on a multi-parent backcrossing population subjected to high-density sequencing; the gene map-based cloning time is shortened and a molecular breeding process is greatly accelerated.
Owner:SHENZHEN INST OF BIOLOGICAL BREEDING & INNOVATION CHINESE ACADEMY OF AGRI SCI

Method for establishing genetic map of identifying true and false of baijiu

The invention discloses a method for establishing a genetic map of identifying the true and false of baijiu. According to the method, DNA in the baijiu is extracted, amplification is conducted througha random primer polymerase chain reaction technology, separation and color development are conducted through gel electrophoresis, and the genetic map is drawn and used for identifying the true and false of the baijiu. According to the identification technology, the technical support can be provided for all baijiu production factories and quality monitoring and market supervision departments at all levels, thereby allowing the factories and the departments to take action actively, quickly and accurately during rights protection and law enforcement, and protecting the legitimate rights and interests of enterprises and consumers.
Owner:江苏权正检验检测有限公司

Gene sequence processing method, computer storage medium and electronic equipment

The invention provides a gene sequence processing method, a computer storage medium and electronic equipment, and the gene sequence processing method comprises the following steps: S1, uploading a gene sequence, and setting a restoration password; s2, storing the gene sequence set with the reduction password as a gene picture in a picture format; s3, uploading the gene picture, inputting a password, and judging whether the password is matched with the restored password or not; and S4, when the password is matched with the reduction password, reducing the gene picture into the gene sequence. According to the gene sequence processing method provided by the embodiment of the invention, when the gene sequence is stored, the gene sequence is converted into a picture format to be stored, so that the space occupied by data storage can be greatly reduced, the transmission speed of the gene sequence is increased, and the gene sequence is encrypted in the process of converting the gene sequence into a picture; information security can be effectively improved.
Owner:YUNZHOU BIOSCIENCES (GUANGZHOU) INC
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