The invention discloses nano
drug carrier particles for improving the
bioavailability of rapamycin and a preparation method thereof, so as to carry out a
drug effect optimization. The nano
drug carrier particles are prepared in the following steps that according to the principle of an
emulsion solvent evaporation method, a determined amount of PEG-
PLGA and rapamycin are respectively dissolved in
acetone; after being mixed uniformly, the PEG-
PLGA, the rapamycin and the
acetone are slowly added into water to be stirred by magnetic force; after a certain period of time, the obtained liquid is ultrasonically homogenated, and organic phase is removed in a vacuum dryer; the obtained water phase removes free
medicine in a centrifugal tube; and then an
ultrafiltration tube is used for concentration, and nano particles are obtained after freezing and
drying. The method has the advantages of convenience in operation, simplicity and feasibility, good
repeatability and the like. The prepared nano
drug carrier particles can improve the
utilization rate of the
medicine by improving the absorptivity of the
medicine and prolonging the
cycling time in a
human body. Meanwhile, the nano particles which are prepared through the method have good
biocompatibility, and surface active groups can further modify ligands or targeted groups.