374 results about "Dermal irritation" patented technology

This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as alpha-(Alpha) Hydroxy Acids (AHA), beta-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

A direct emulsion for bleaching keratin fibers, preferably human keratin fibers such as hair, having an inert phase containing of a nonoxygenated and nonperfluorinated liquid compound having a water-solubility at 25° C. of less than 1% and an aqueous hydrogen peroxide solution, a bleaching method using this direct emulsion, as it is or in the form of a ready-to-use composition, and the use of this direct emulsion for bleaching keratin fibers. The direct emulsion in accordance with the invention makes it possible to rapidly obtain substantial lightening of keratin fibers while limiting the degradation of the keratin fibers and skin irritation.

An improved method is provided to enhance skin appearance and health, in which skin is cleaned (or exfoliated) and conditioned by use of microelements affixed to a base element or hand-held patch. For the microstructure used in the improved method, the dimensions of the microelements are controlled so as to remove a certain number of layers of skin cells and to accumulate and retain those skin cells, along with other foreign substances, into areas between the microelements. In another embodiment of the improved method, a conditioning compound or therapeutic active can be applied to the exfoliated skin to enhance the skin. Moreover, the amount of skin cells accumulated using the improved method represents a self-limiting maximum quantity that cannot be substantially exceeded regardless of the number of attempts by a user to re-use the microstructure apparatus associated with the improved method. Some of the microelement shapes are purposefully designed with distal ends that exhibit sharp edges rather than sharp tips to reduce skin irritation resulting from use of the improved method.

A monolithic device for transdermal administration of an active pharmaceutical ingredient which is selected from propargylamines and rivastigmine and is liquid at 25° C., has an adhesive matrix layer which includes the active ingredient in an acrylic polymer pressure sensitive adhesive without cross-linker agent containing a metal atom, the adhesive having a shear value of between 1.5 and 15 hours, and further includes a non-volatile coadjuvant selected from squalene and triethylcitrate present in the layer in an amount of 1 to 15 wt %. The combination provides good release of the drug in use, reduces loss of the drug during a drying step in manufacture, reduces chemical interaction of the layer with the drug and achieves low level of skin irritation.

An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.

A composition providing electrically conductive adhesive hydrogels suitable for use as skin contact adhesives and, particularly, suitable for use as an electrical interface for disposable medical devices. The present hydrogels provide for reduced skin irritation and / or malodor properties, hydrate a subject's skin, readily wet around a subject's skin surface hair, and protect against burning of a subject upon or due to electrical stimulation through the hydrogel. These hydrogels generally include a monomer, a first initiator, a second initiator, and a cross-linking agent. The present hydrogels also desirably include a solubilizer. The present hydrogels also desirably may include a buffer system to help prevent discoloration of the hydrogels and / or hydrolysis of the hydrogels as well as to improve shelf-life. Other additives such as conductivity enhancers, pharmaceuticals, humectants, plasticizers, skin health agents, etc. may be added to the present hydrogels either before or after curing.

This invention is related to wound dressings, supports, protection and care in humans and animals. Commonly, adhesives and wraps are used for this purpose. However, the use of adhesive have multiple problems: they are difficult to use with elastic gloves since the adhesive tapes stick to the gloves, cause skin irritations and discomfort on removal, and do not adhere to the skin covered by hairs. Many times the hair must be shaved which is a process of its own. Wound inspections or the exchange of dressing multiplies their problems and prohibits this process. Furthermore, wound wrapping cannot be done by use of adhesive tapes in an effective and convenient manner. Then, of course, is the major issue of dressing a wound with one hand only, that occurs in certain circumstances. It is very important to have a system that allows a person to be able to dress a wound solely with one hand, since the other one may be wounded. These units are extremely helpful in this regard. Lastly, at times the wound dressing should be done as quickly as possible, and obviously speed makes a big difference in manmade or natural disasters. Also in many cases the wound site needs to be protected by means that will prevent objects from touching the skin or the wound site, in order to prevent ulceration, avoid discomfort or simply the mere protection of the wounds. In some other cases, the vascular problems of the wounds need to be addressed for better care. This would, in some cases, need means of squeezing the wound site, and in other cases allow a better drainage of the wounds. The methods and means introduced solves many of these problems. This application introduces new methods and means of dressings that makes the process of wound dressing faster, easier, and applicable with one hand only. It practically eliminates the use of adhesives and / or decreases their use significantly. In this model, a support unit made from a non-stretchable material, commonly in a rectangular or trapezoid shape, is used on the wound to hold the gauze pad or wound dressing in place. This unit uses at least one strap made of a particular stretchable material that allows the strap to attach to the support on a detachable, re-attachable basis to a band of the hook fastener on the surface. Importantly, this attachment can be done in any part of this strap. Also importantly, this support system uses one or two narrow bands made from the same material as the strap, which allows them to wrap around the limb from the opposite side of the strap to attach to the support on a detachable, re-attachable basis. Next, the main strap will attach to the support on detachable, re-attachable basis. In some models the support unit will function as the stabilizer of the system or to make the functions simpler. This main idea is then used to make multiple models for use in different areas. The application has also shown modified versions of these units that function to prevent ulcerations from starting in places such as the heels. In some other models the applicant shows units that guard the wound site and prevent objects from touching the skin or the wound site for avoiding discomfort or mere protection of the wounds. In patients who have vascular problems the models shown here allow the wound in the heels to be squeezed to prevent and reduce tissue swelling. In other cases, the applicant shows means that allow a limb to be elevated for a better drainage. All in all, the applicant tries to introduce units for improving human and animal quality of life.

The present invention relates to absorbent articles including non-aqueous compositions for protecting the barrier function of the skin. The compositions can be applied to the bodyfacing surfaces of absorbent articles so that the compositions come into contact with the skin. The compositions of the invention have improved stability on the bodyfacing surfaces after processing. The compositions of the invention provide several benefits including prevention and alleviation of skin irritations associated with the use of absorbent articles. The compositions can include emollients, viscosity enhancers and anionic polymers.

A regulated heat source is described that can be applied to a skin lesion, such as pustular-form eruption or localized abscess, in order to accelerate the death of invading bacteria, fungi or viral particles, or to assist in the breakdown of a skin irritant and thereby speed the recovery process.

A composition providing electrically conductive adhesive hydrogels suitable for use as skin contact adhesives and, particularly, suitable for use as an electrical interface for disposable medical devices. The present hydrogels provide for reduced skin irritation and / or malodor properties, hydrate a subject's skin, readily wet around a subject's skin surface hair, and protect against burning of a subject upon or due to electrical stimulation through the hydrogel. These hydrogels generally include a monomer, a first initiator, a solubilizer, and a cross-linking agent. The present hydrogels also desirably include a buffer system to help prevent discoloration of the hydrogels and / or hydrolysis of the hydrogels as well as to improve shelf-life. Other additives such as conductivity enhancers, pharmaceuticals, humectants, plasticizers, skin health agents, etc. may be added to the present hydrogels either before or after curing.

A scar treatment silicone dressing used for attaching onto wound of skin, comprising: a surface layer, a connection layer, a silicone layer, and a protection film. The surface layer is moisture permeable and water resistant thus providing protection function, and on one of its sides is disposed a silicone layer through a connection layer. The silicone layer is provided with penetrating through holes for controlling dissipation of moisture of skin wounds, as such assisting skin exiting perspiration to said surface layer via said through holes, hereby reducing the possibility that the acidic metabolite in perspiration getting in touch with the skin for long period of time in causing irritations / inflammations of the skin; meanwhile, it is also capable of preventing over-dissipation of moisture from the surface of skin, thus it will not adversely affect the repair and reconstruction of the scar tissue.

A personal cleansing composition exhibiting enhanced skin feel (i.e., enhanced skin softness, reduced skin irritation, reduced residue, and reduced greasy, tacky, or tight skin feel), enhanced foaming and lather, and good cleansing, more specifically, a personal cleansing composition comprising a mixture of alpha sulfonated alkyl esters or sulfonated fatty acids, or salts thereof, with an alkyl sulfoacetate or ethoxylated alkyl sulfoacetate, or salts thereof, secondary surfactants, and optional additives.

Methods of reducing skin irritation induced by a surfactant are described that comprise contacting skin with a detergent comprising at least one surfactant and at least one botanical extract, wherein the at least one botanical extract at least partially counteracts irritation induced by the at least one surfactant.

Panthenol combined with natural organic extracts are well suited for reducing skin irritation that is normally elicited by exposure to irritant active agents or compounds, particularly found in hair permanent and relaxing compositions, hair colorants and depilatories.

Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compounds, Cox-2 inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, local anaesthetics, chelating agents, matrix metalloprotease inhibitors, inhibitors of inflammatory cytokines, glucosamine, chondroitin sulfate and collagen hydrolysate. Also disclosed are pharmaceutical compositions and methods of treatment for inflammatory disease and local inflammation and dermal irritation. Also disclosed are compositions including tetracycline and at least one compound useful for treatment of inflammatory disease.

The present invention is concerned with novel compositions containing fresh or virgin beeswaxes and oil, with and without water, and the utilization of such compositions for the treatment of skin in animals including man, for treatment for first, second, and third degree (partial and full thickness) burns due to sunburn, windburn, scalds, flash flame, electrical contact, chemical contact, cold, and the like, for use as a preventive aid for sunburn, windburns, skin chapping, chafing and the like, for promoting and accelerating the healing of burns, abrasions, lacerations, cuts, scratches, dry skin, chapped skin, wind burned skin, friction-type burns, chafing and the like, for use as a softening and moisturizing agent, for use in the reduction of wrinkles, for use as a topical application to irritations of the skin, including dry lips, chapped skin, abrasions, and the like, for use as an analgesic to be applied topically for the treatment and alleviation of pain in the skin and underlying tissues, for use as a protective barrier between the skin and other irritants, eg, saliva, urine, fecal material, various chemical irritants and the like, and for use as a base to which may be added other agents also promoting treatment, moisturization, protective or preventive measures for the skin.

A method for reducing an occurrence of irritation and / or inflammatory reaction in human skin includes applying a topical preparation to the skin. The preparation includes an amount of an agent effective to reduce an occurrence of irritation and / or inflammatory reaction in human skin. The agent includes idebenone or a derivative of idebenone.

Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compounds, Cox-2 inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, local anaesthetics, chelating agents, matrix metalloprotease inhibitors, inhibitors of inflammatory cytokines, glucosamine, chondroitin sulfate and collagen hydrolysate. Also disclosed are pharmaceutical compositions and methods of treatment for inflammatory disease and local inflammation and dermal irritation. Also disclosed are compositions including tetracycline and at least one compound useful for treatment of inflammatory disease.

A protein modified to improve its stability, said modified protein being coupled to a beta-1,3-glucan branched with beta-1,6-linkage is provided. A method for the production thereof and a cosmetic or dermatological composition comprising the modified protein are also provided. The modified protein shows an improved stability while retaining its activity and being free of skin irritation.

This invention relates to antimicrobial fabrics which are treated with a specific durable and regenerable halamine / chlorine system and methods of removing residual active chlorine from the target textile surface without reducing the antimicrobial activity of the textile. Such methods comprise contacting an amine-treated fabric first with a halogen-based bleach (or other halogenated liquid) to produce halamines at the fabric surface, and subsequently washing the resultant halogenated fabric with a reducing agent which removes the residual, unbonded halogen (such as chlorine) from the fabric surface but does not, surprisingly, remove the halamine halogen. The remaining halamine halogen thus provides the desired antimicrobial activity. As a result, a method of substantially reducing fabric discoloration, odor, and potential skin irritation due to the presence of amounts of residual unbonded halogen (such as chlorine) on the target fabric surface is provided which simultaneously permits sufficient amounts of halamine halogen (such as chloramine chlorine) to remain on the target fabric for optimum microbiocidal propoerties. A fabric treated in accordance with this method is also provided.

This invention relates to methods and compositions for preventing and treating skin rash, such as perineal dermatitis, associated with enzymatic dermatitis. More particularly, this invention relates to compounds containing procyanidins, which possess trypsin and / or chymotrypsin inhibitory activity and are suitable for use in compositions for preventing and treating skin irritation caused by protease exposure, such as perineal dermatitis.

A dermatomol somatosensory evoked potential (DSSEP) diagnositic apparatus for evaluating nerve root functions in a mammalian subject is presented. The DSSEP apparatus includes an electrical stimulator, a stimulus site selector switchbox, a connection box, a plurality of stimulating electrodes, a plurality of recording electrodes, a computer system, and a software package. The stimulating electrodes are configured to receive and to apply an electrical stimulus onto a dermal stimulation site of the mammalian subject. The recording electrodes are configured to receive an evoked potential induced by the applied electrical stimulus such that the evoked potential response passes through nerves from the dermal stimulation site to the dermal recording site. The computer system and software package process the results.

The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.

A CFS system includes self-adhesive, disposable pads. Each pad is combined with a sealed, cleanable battery / controller pod and then placed on the body where needed. The battery / controller pod preferably has wireless capability, such as Bluetooth® capability. The patient can download an application to a smartphone or similar mobile device to control the pods.

The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs.

Formulations of active agent particles of less than 100 microns in a droplet of dispersant, which is coated with a matrix of cationic and anionic polymers, are efficient vehicles for delivering active agents to tissues such as skin and mucosal membranes. Such formulations are able to deliver compounds to skin with little associated irritation. Prior art topical formulations typically have the disadvantage of causing significant skin irritation.

The invention provides a nursing traditional Chinese medicine disinfectant and a preparation method. The nursing traditional Chinese medicine disinfectant comprises, by weight, 10-20 grams of camphor bark, 5-10 grams of honeysuckle, 8-12 grams of light-yellow sophora root, 5-15 grams of glabrous greenbrier rhizome, 10-15 grams of common cnidium fruit, 4-6 grams of coptis, 3-5 grams of ginger, 4.2-6.5 grams of safflower, 10.5-12g grams of cortex dictamni, 12.4-13 grams of aloe and 7.8-12.8 grams of ginkgo seeds. The preparation method includes the steps: (1) weighting the raw materials by weight; (2) adding water into the raw materials for decocting twice, filtering, mixing filtrates and adding sterile water into the mixture to 1000ml; and (3) adding 5 grams of nonyl phenol polrvinyl chloride ether and 10 grams of glycerol into the mixture with uniformly stirring, and adding 2 grams of available iodine and 2 grams of metronidazole with uniformly stirring. The nursing traditional Chinese medicine disinfectant is good in disinfection effect, low in skin irritation, suitable for disinfecting the skin and capable of disinfecting clothes and tableware.

There are disclosed topical compositions for alleviation of skin irritation symptoms or conditions having at least one plant extract effective to inhibit COX-2 enzyme, NGF protein, and / or TNF-alpha protein activity. Preferably, the compositions have a cosmetically, dermatologically, or pharmaceutically acceptable vehicle. In addition to the enzyme inhibitory plant material and acceptable vehicle, compositions may also have at least one active ingredient known to produce skin irritation. There is also a method for treatment of skin irritation symptoms or conditions involving topically applying compositions of the invention. Also disclosed are compositions and methods for topical administration of compositions to the skin that improve the aesthetic appearance of skin and / or provide an anti-aging benefit to the skin.

The present invention discloses certain di- and polyvalent metal zeolite compounds (formula I) for topical delivery of biological and skin and hair care agents. The method of treating skin and hair condition via topical application of said zeolite compounds is also disclosed. The said method provides a treatment for topical condition, which includes alleviation of skin conditions such as skin rash including diaper rash, dry skin, scalp dandruff, broken or chafed skin, sunburn, skin damage from UV, skin irritation, acne including excess facial oil and facial pore size; darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; body odor, including oral cavity odor, arm-pit odor, and incontinence odor; cellular inflammation including intracellular and extra cellular inflammation; premature hair aging including premature hair loss hair graying; malfunction of tyrosinase group of enzymes, malfunction of matrix metalloprotease group of enzymes; and combinations thereof. The said method also provides topical delivery of certain metals, including trace metals, and certain zirconium aluminum amino acids that provide antiperspirant benefits;