371 results about "Dermal irritation" patented technology

A monolithic device for transdermal administration of an active pharmaceutical ingredient which is selected from propargylamines and rivastigmine and is liquid at 25° C., has an adhesive matrix layer which includes the active ingredient in an acrylic polymer pressure sensitive adhesive without cross-linker agent containing a metal atom, the adhesive having a shear value of between 1.5 and 15 hours, and further includes a non-volatile coadjuvant selected from squalene and triethylcitrate present in the layer in an amount of 1 to 15 wt %. The combination provides good release of the drug in use, reduces loss of the drug during a drying step in manufacture, reduces chemical interaction of the layer with the drug and achieves low level of skin irritation.

This invention is related to wound dressings, supports, protection and care in humans and animals. Commonly, adhesives and wraps are used for this purpose. However, the use of adhesive have multiple problems: they are difficult to use with elastic gloves since the adhesive tapes stick to the gloves, cause skin irritations and discomfort on removal, and do not adhere to the skin covered by hairs. Many times the hair must be shaved which is a process of its own. Wound inspections or the exchange of dressing multiplies their problems and prohibits this process. Furthermore, wound wrapping cannot be done by use of adhesive tapes in an effective and convenient manner. Then, of course, is the major issue of dressing a wound with one hand only, that occurs in certain circumstances. It is very important to have a system that allows a person to be able to dress a wound solely with one hand, since the other one may be wounded. These units are extremely helpful in this regard. Lastly, at times the wound dressing should be done as quickly as possible, and obviously speed makes a big difference in manmade or natural disasters. Also in many cases the wound site needs to be protected by means that will prevent objects from touching the skin or the wound site, in order to prevent ulceration, avoid discomfort or simply the mere protection of the wounds. In some other cases, the vascular problems of the wounds need to be addressed for better care. This would, in some cases, need means of squeezing the wound site, and in other cases allow a better drainage of the wounds. The methods and means introduced solves many of these problems. This application introduces new methods and means of dressings that makes the process of wound dressing faster, easier, and applicable with one hand only. It practically eliminates the use of adhesives and / or decreases their use significantly. In this model, a support unit made from a non-stretchable material, commonly in a rectangular or trapezoid shape, is used on the wound to hold the gauze pad or wound dressing in place. This unit uses at least one strap made of a particular stretchable material that allows the strap to attach to the support on a detachable, re-attachable basis to a band of the hook fastener on the surface. Importantly, this attachment can be done in any part of this strap. Also importantly, this support system uses one or two narrow bands made from the same material as the strap, which allows them to wrap around the limb from the opposite side of the strap to attach to the support on a detachable, re-attachable basis. Next, the main strap will attach to the support on detachable, re-attachable basis. In some models the support unit will function as the stabilizer of the system or to make the functions simpler. This main idea is then used to make multiple models for use in different areas. The application has also shown modified versions of these units that function to prevent ulcerations from starting in places such as the heels. In some other models the applicant shows units that guard the wound site and prevent objects from touching the skin or the wound site for avoiding discomfort or mere protection of the wounds. In patients who have vascular problems the models shown here allow the wound in the heels to be squeezed to prevent and reduce tissue swelling. In other cases, the applicant shows means that allow a limb to be elevated for a better drainage. All in all, the applicant tries to introduce units for improving human and animal quality of life.

The present invention is concerned with novel compositions containing fresh or virgin beeswaxes and oil, with and without water, and the utilization of such compositions for the treatment of skin in animals including man, for treatment for first, second, and third degree (partial and full thickness) burns due to sunburn, windburn, scalds, flash flame, electrical contact, chemical contact, cold, and the like, for use as a preventive aid for sunburn, windburns, skin chapping, chafing and the like, for promoting and accelerating the healing of burns, abrasions, lacerations, cuts, scratches, dry skin, chapped skin, wind burned skin, friction-type burns, chafing and the like, for use as a softening and moisturizing agent, for use in the reduction of wrinkles, for use as a topical application to irritations of the skin, including dry lips, chapped skin, abrasions, and the like, for use as an analgesic to be applied topically for the treatment and alleviation of pain in the skin and underlying tissues, for use as a protective barrier between the skin and other irritants, eg, saliva, urine, fecal material, various chemical irritants and the like, and for use as a base to which may be added other agents also promoting treatment, moisturization, protective or preventive measures for the skin.

A method for reducing an occurrence of irritation and / or inflammatory reaction in human skin includes applying a topical preparation to the skin. The preparation includes an amount of an agent effective to reduce an occurrence of irritation and / or inflammatory reaction in human skin. The agent includes idebenone or a derivative of idebenone.

This invention relates to methods and compositions for preventing and treating skin rash, such as perineal dermatitis, associated with enzymatic dermatitis. More particularly, this invention relates to compounds containing procyanidins, which possess trypsin and / or chymotrypsin inhibitory activity and are suitable for use in compositions for preventing and treating skin irritation caused by protease exposure, such as perineal dermatitis.

The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.