The invention discloses an improved dogskin plaster for dispelling cold and dampness, activating blood circulation and relieving pain, and a preparation method and application thereof. The dogskin plaster is prepared from the following raw material medicines in parts by mass: 20 to 35 parts of radix aconiti kusenzoffii, 15 to 36 parts of galangal, 20 to 34 parts of cortex cinnamomi, 18 to 35 of angelica sinensis, 20 to 40 parts of radix stephaniae tetrandrae, 15 to 40 parts of ephedra, 10 to 25 parts of safflower carthamus, 5 to 20 parts of flos daturae, 3 to 10 parts of celandine, 12 to 25 parts of pepper, 20 to 35 parts of venenum bufonis, 10 to 25 parts of white cabbage seeds, 16 to 25 parts of phryma leptostachya, 21 to 38 parts of myrrh, 10 to 35 parts of frankincense, 5 to 18 parts of star anise oil, 20 to 30 parts of rhizoma curculiginis, 3 to 8 parts of melon skin, 30 to 50 of pseudo-ginseng, 10 to 20 of salviae miltiorrhizae, 20 to 50 of cowherb seeds, 5 to 10 of platycodon grandiflorum, 15 to 30 parts of radix saposhnikoviae, 10 to 40 parts of notopterygium roots, 20 to 50 parts of xanthium, 30 to 60 parts of dried ginger, 10 to 20 parts of cinnamon, 30 to 40 parts of rhizoma corydalis, 5 to 10 parts of China rose, 40 to 60 parts of poria cocos, 7 to 15 parts of akebiaquinata, 10 to 20 parts of mulberry leaves, 8 to 15 parts of dandelions, 10 to 30 parts of fructus chaenomelis lagenariae, 15 to 25 parts of borneol, 8 to 15 parts of camphor, 2 to 5 parts of diphenhydramine hydrochloride, 3 to 7 parts of methyl salicylate and 4 to 8 parts of a transdermal absorbent.