147 results about "ChloraPrep" patented technology

PCT No. PCT / US96 / 20932 Sec. 371 Date Jun. 30, 1998 Sec. 102(e) Date Jun. 30, 1998 PCT Filed Dec. 23, 1996 PCT Pub. No. WO97 / 25085 PCT Pub. Date Jul. 17, 1997The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight / weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

The invention provides a cream composition which comprises bacteriostatic agents, glycerin and deionized water. The mass ratio of the bacteriostatic agents to the glycerin to the deionized water is 0.1-22:10-97:3-9. The bacteriostatic agents are at least one type of polyhexamethylene guanidine hydrochloride, polyhexamethylene biguanidine hydrochloride, iodopropynyl butylcarbamate, 2-methyl-4-amino-6-methoxy s-triazine, benzalkonium bromide, chloretone, sulfoacid pyrimidine sodium, diclofenac sodium, chlorhexidine and myristylpicolinum bromide. The invention further provides paper comprising the cream composition. The cream composition is formed on the outer surface of the paper, so that the paper realizes moisture retention, sterilization and bacteriostasis effects when used for wiping the skin of a user, and feels comfortable and soft.

The invention discloses a disinfection sterilization medical ultrasonic coupling medium with the bactericidal function and used in the ultrasonic detection and treatment of skin and cavitary mucosa and a preparation method of the coupling medium, wherein, the ultrasonic coupling medium comprises propylene glycol, de-ionized water and one viscosity modifier of the hydroxy ethyl cellulose, carbomerand hydroxy propyl cellulose. The coupling medium further comprises a fungicide of 0.05 to 0.15 percent and the constituents of the fungicide are any one of polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, trichlorobenzene phenoxy diphenyl ether and nanometer silver or any combination of the olyhexamethylene biguanide, the benzalkonium chloride, thebenzalkonium bromide, the chlorhexidine acetate, the trichlorobenzene phenoxy diphenyl etherand, and the nanometer silver; the preparation method used for preparing the ultrasonic coupling medium is as follows: dispersing the hydroxy ethyl cellulose in the propylene glycol, stirring and dispersing the hydroxy ethyl cellulose by adding enough water, heating to 75 to 80 DEG C, preserving the heat for 30 minutes to cool the hydroxy ethyl cellulose and the propylene glycol to 45 DEG C, adding the fungicide to stir and cool the fungicide, the hydroxy ethyl cellulose and the propylene glycol to obtain the filled coupling medium. Tests show that the products of the coupling medium have fast and long sterilization effect and meet the requirements of various related standards.

The invention relates to a disinfectant, and aims to provide a compound chlorhexidine acetate microemulsion disinfectant having the advantages of good water solubility, strong disinfection effect, long disinfection effect maintenance time and good stability, and its preparation method. The compound chlorhexidine acetate microemulsion disinfectant is prepared through using the following raw materials, by weight, 0.02-11.0 parts of chlorhexidine acetate, 0-11.0 parts of benzalkonium bromide, 18.5-30.2 parts of a surfactant, 0-18.6 parts of a cosurfactant, 2.7-5.0 parts of oil and 36.6-67.2 parts of distilled water. The compound chlorhexidine acetate microemulsion disinfectant has the advantages of high chlorhexidine acetate content, use convenience, simple production technology, low production cost, and convenience for the scale production.

The invention relates to an antibacterial transparent dressing, a preparing method of the antibacterial transparent dressing and application of the antibacterial transparent dressing. The antibacterial transparent dressing comprises a polymer gel lining pad and a transparent protective film, wherein the polymer gel lining pad has moisture absorption performance and long-acting bacteriostasis performance; antibacterial drug is contained in the polymer gel lining pad; the polymer gel lining pad is prepared from materials of the following polymer monomers including hydroxyethyl methylacrylate, methyl methacrylate, cinnamic acid, alpha-cyanoacrylate, alpha-carboxymethyl crylic acid, methyl alpha-chloroacrylate and crylic acid-2-hydroxyl ethyl ester; the antibacterial drug is selected from chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene guanide salts and triclosan; the transparent protective film is a polyurethane thin film.

This invention provides a modified catheter / indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA) as an option, a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation. Alternatively, the sparsely soluble silver salt can be silver iodate and is combined with silver sulfadiazine. Chlorhexidine can also be included in the material.

The invention relates to a gel preparation for treating gynecological diseases. The gel preparation consists of chitosan with specific molecular weight and degree of deacetylation, chlorhexidine, glycerin, an acidifying agent and purified water. The preparation method comprises the following steps of: mixing the chitosan with the purified water to form suspension liquid in an environment with cleanliness at one-hundred-thousand level; adding the acidifying agent to regulate pH to 3.8-5.8 to obtain chitosan gel; dissolving chlorhexidine in the glycerin, adding into the chitosan gel, uniformly stirring, degassing, filling, sealing, and sterilizing to obtain the gel preparation, wherein the acidifying agent is lactic acid, acetic acid or a hydrochloric acid-acetic acid mixture; and the sterilizing mode is cobalt-60 irradiation treatment or high-temperature damp-hot sterilization. The gel has good adhesion force, uniform color and good stability, is used for treating women monilial vaginitis, bacterial vaginitis, mixed vaginitis, cervicitis, cervical erosion and the like, and has the advantages of being good in curative effect, safe, natural, good in biocompatibility and the like. The invention further relates to a preparation method and medical application of the gel preparation.