32 results about "Binding Determinants" patented technology

The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.

A computerized method and system for detection and quantification of changes in color on skin or internal tissue or organs within the human body. Digital images of the skin or tissue containing an area of interest are analyzed using the software of the invention, based on at least one channel of the LAB color system. The invention calculates the intensity and distribution of color present within the predetermined area of interest, and results in display of at least one color information attribute. The invention allows color calibration of the image to be performed in relation to a reference label having predetermined colors which surrounds the area of interest, prior to the analysis. The invention allows a threshold analysis to be performed, which graphically depicts the size and location of areas exhibiting significant change in color, which is a determinant factor in medical diagnosis.

Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.

Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

The present invention provides a comprehensive method to design an automatic media audience measurement system that can estimate the site-wide audience of a media of interest (e.g., the site-wide viewership of a target display) based on the measurements of a subset of the actual audience sampled from a limited space in the site. This invention enables (1) the placement of sensors in optimal positions for the viewership data measurement and (2) the estimation of the site-wide viewership of the target display by performing the viewership extrapolation based on the sampled viewership data. The viewership extrapolation problem is formulated in a way that the time-varying crowd dynamics around the target display is an important decisive factor as well as the sampled viewership data at a given time in yielding the estimated site-wide viewership. To solve this problem, the system elements that affect the viewership—site, display, crowd, and audience—and their relationships are first identified in terms of the visibility, the viewership relevancy, and the crowd occupancy. The optimal positions of the sensors are determined to cover the maximum area of the viewership with high probabilities. The viewership extrapolation function is then modeled and learned from the sampled viewership data, the site-wide viewership data, and the crowd dynamics measurements while removing the noise in the sampled viewership data using the viewership relevancy of the measurements to the target display.

A low-loss surface acoustic wave filter on a quartz substrate with optimized cutting. A range of cutting angles and directions of propagation of the waves on the quartz substrate are defined, making it possible to obtain high coefficients of reflection of the electrodes used in the filter. The range of cutting angles and directions of propagation of the waves are decisive factors for the making of the filter.

The invention relates to a photovoltaic module cleaning method. The method comprises steps: 1) related data for decisive factors influencing whether the photovoltaic module is cleaned or not are acquired, the data are processed, and accurate values of the decisive factors which are a generation gain level, a sediment transport rate, a precipitation amount and a module masking rate influencing whether the photovoltaic module is cleaned or not are obtained; 2) the accurate values of the generation gain level, the sediment transport rate, and the precipitation amount obtained in the first step are fed to a first-stage fuzzy controller for processing, and an initial cleaning index, that is, the initial cleaning probability of the photovoltaic module, is obtained; and 3) the accurate value of the module masking rate obtained in the first step and the initial cleaning index obtained in the second step are fed to a second-stage fuzzy controller for processing, and a cleaning decisive index is obtained. Thus, a decisive data support is provided for cleaning of the photovoltaic module, the defect that the original photovoltaic module cleaning decision subjective consciousness is strong is broken, and thus, cleaning and maintenance of the photovoltaic power station module are more scientific.

The invention relates to a PCA-ELM based coal mine water inrush prediction method and belongs to the field of coal mine water inrush prediction methods. The method comprises the steps of obtaining a plurality of data affecting coal mine water inrush in the coal mine normal exploitation running state; screening a plurality of factors affecting coal mine water inrush through the PCA to obtain a main controlling factor playing a decisive role in coal mine water inrush; partitioning sample data only containing the main controlling factor into a training set, a verification set and a testing set which are corresponding to model training, verification and testing respectively; building an ELM network model, and training the data through the ELM algorithm; verifying a coal mine water inrush prediction model through the verification data, beginning to rebuild a model from the PCA if the obtaining prediction result has no apparent advantages compared with other algorithms, and using the model as the prediction model for actually predicting the coal mine water inrush prediction condition if the prediction result is ideal.

The invention discloses an unrestrictive expected operation life assessment method for a distribution network lightning arrester under a given confidence level. The method comprises the following steps of: 1, monitoring the lightning overvoltage amplitudes at the installation position of the lightning arrester in one year, and counting the amplitude distribution; 2, calculating the statistical distribution of lightning impact discharge capacity resource consumption of the lightning arrester in one year; and 3, calculating the unrestrictive / restrictive lightning overvoltage expected life of the lightning arrester under the given confidence level. According to the method, the lightning overvoltage serving as a decisive factor of the service life of the lightning arrester for a distribution network is analyzed, a route and a method for calculating lightning discharge capacity resource of the lightning arrester for the distribution network and one-time lightning arrester lightning discharge capacity resource consumed by overhead circuit overvoltage due to lightning are further introduced, and finally, the expected operation life of the lightning arrester for the distribution network is calculated by adopting simplified parameters and the method.

A light-to-electrical energy conversion device comprising a nano structure is formed on a surface of a semiconductor substrate. The nanostructure comprises an array of basic light antenna nanocells, with the individual antenna nanocells formed as “rectenna” structures. Light energy is absorbed within each independent antenna nanocell and converted to direct current. In one particular configuration, the structure of each basic nanocell comprises a cavity or cavities dimensioned to accept light as the wave of classical physics. These cavities function as quantum confinement sites for electrons that constitute an absorbing mass. The cavity dimensionality provides a determinative factor in wavelength discrimination of the nanocell structure.

The invention relates to a device and a method for measuring temperature and radioactive rays with fiber bragg grating (FBG) sensors. The invention relates to a technology that accurate measurement can be carried out by covering a hollow radioactive ray shielding member on a sensor with two FBG sensors to separate the radioactive ray values and temperature values obtained from the two sensors. According to the invention, no matter in a nuclear station in a normal state or an apparatus generating the radioactive rays, the device can be used as a commonly used sensor system for measuring temperature and radioactive ray quantity, and also realizes commercialization. When a nuclear accident happens, the device also can be used as a sensor system which can remotely measure the temperature and radioactive ray radiation quantities that play critical facts for mastering inner information of accident environment by means of a fiber circuit.

The mass is structured on the basis of calcium aluminate cement, aggregates, water and chemical additives that modify the characteristics of the concrete. This mass uses magnetite, hematite or steel shot as an aggregate, with a highly continuous granulometry so as to achieve perfect consistency in the mass (Fuller's curve), accompanied by a high density, decisive factors for an optimum barrier effect against radiations. It can withstand high temperatures without there being any structural loss and it therefore maintains the barrier effect. The mass is suitable for producing poured concrete, concrete for bricks, and mortar, for use in the building of radioactive enclosures in which energies above 450 KeV, etc. are handled.Furthermore, prefabricated blocks of mixed mass, one of high density with great heat accumulation capacity and the other with the opposite effect, i.e. of low capacity and low conductivity, enable the prefabricated blocks to emit the thermal energy from the same faces by which they absorb it

The invention provides a preparation method of a polyacrylonitrile nanofiber porous membrane. The preparation method of the polyacrylonitrile nanofiber porous membrane achieves preparation of the polyacrylonitrile membrane through a simple scraping method, during which quick freezing serves as a determining factor for preparing high-density and low-porosity casting pieces; high degree of supercooling can induce rapid phase separation and gelation of a film casting liquor system; lower-temperature freezing can rapidly cure a structure produced by phase separation and gelation of the film casting liquor system to avoid growth of large pores and finally to obtain the high-density and low-porosity casting pieces; lastly, the production and tensile pore expanding mechanism of biaxially orientedinduced fiber can help form a polyacrylonitrile nanofiber membrane structure. The preparation method of the polyacrylonitrile nanofiber porous membrane is simple in process and applicable to industrialization; the prepared polyacrylonitrile nanofiber porous membrane is high in porosity and good in breathability.

The invention belongs to the technical field of medicines, and relates to a medicine containing oxygen, a preparation method of the medicine and use of the medicine as a pharmaceutical active ingredient for regulating intestinal microbial communities in preparation of drugs, and particularly to the use of the medicine in preparation of the drugs for preventing or / and treating diseases related to intestinal flora imbalance. The concentration of the oxygen in the environment is a decisive factor for regulating and controlling the distribution structure of microorganisms in the environment.

The invention discloses an additive for a positive pole of a lead-carbon battery, which is highly controllable in component and crystal form and a preparation method of a pole plate for the positive pole of the lead-carbon battery. The additive is an alpha / beta-PbO2-SiO2 compound which is prepared by constant-current electrodeposition; the pole plate is prepared from lead powder, alpha / beta-PbO2-SiO2, colloidal graphite and a short fiber. As an excellent electrolyte storage medium, silicon dioxide has certain elastic deformation ability, after being added into the positive role of the lead-carbon battery, while being capable of providing more effective reactive ions for an internal active substance, is used for providing physical buffer action when the pole plate generates deformation, andis used for relieving the phenomenon that lead plaster falls off due to geometrical bending. However, lead dioxide is used as a basic active substance for the positive pole; the crystal form of the lead dioxide is a decisive factor of influencing the electrochemical property of a material. The pole plate prepared from the compound provided by the invention can be used for obviously improving theeffective utilization ratio of an active substance and the corrosion-resistant ability of the pole plate; the falling-off phenomenon in a high-rate partially charged state is effectively relieved, andthe overall energy density and cycle life of the battery are improved.

The designed floating charge service life of a storage battery pack can be 18 to 20 years, but the storage battery packs currently used for starting various vehicles are easily damaged and frequently replaced. Such a great difference appears because that: floating charge voltage is a decisive factor of the utilization efficiency and the service life of the storage battery, and in particular, only average charging power is adapted to the obvious changes of the internal microstructure, the charge state and the external ambient temperature of the storage battery pack, a proper charging process can be always ensured in the whole life cycle of the storage battery pack, or quick positive plate gate corrosion, electrolyte loss, negative and positive plate vulcanization and available capacity reduction are inevitably caused. Therefore, the invention provides an adaptive electricity generating and storing system, which comprises an exciting power actuator, an adaptive storage battery pack, a storage battery pack body temperature sensor, a quick charge controller, a polar plate far-end charge controller, a transmitting controller, an overheat protector and marking graphs. The adaptive electricity generating and storing system is applied to systems, such as vehicles, mobile communication base stations and the like, adopting a floating application mode.

The invention relates to a device and a method for measuring temperature and radioactive rays with fiber bragg grating (FBG) sensors. The invention relates to a technology that accurate measurement can be carried out by covering a hollow radioactive ray shielding member on a sensor with two FBG sensors to separate the radioactive ray values and temperature values obtained from the two sensors. According to the invention, no matter in a nuclear station in a normal state or an apparatus generating the radioactive rays, the device can be used as a commonly used sensor system for measuring temperature and radioactive ray quantity, and also realizes commercialization. When a nuclear accident happens, the device also can be used as a sensor system which can remotely measure the temperature and radioactive ray radiation quantities that play critical facts for mastering inner information of accident environment by means of a fiber circuit.

The invention relates to an accumulator battery, in particular to an accumulator battery digitizing real-time status measuring and control data of the accumulator battery and transmitting the data to an adaptive charger to realize digitalization of measuring and control in the charging process. Parameter setting in the charging process is a deciding factor of the service life of the accumulator battery along a vehicle; in particular, charging voltage adapts to continuous changes of an internal microstructure of the accumulator battery and external environmental temperature; and in order to ensure that a proper charging process is always kept in the complete life cycle of the accumulator battery, the charger is required to have the capacity of automatically adapting to the changes, so that the accumulator battery is required to be capable of outputting the real-time status measuring and control data to provide support for the charging process. Because related physical descriptors are weak, effective perception and reliable transmission are master keys of success. Therefore, the accumulator battery provides a digitization proposal, comprises a measuring and control module, interface specification and a packaging cavity, and is applicable to electric automobiles and electric bicycles with overlong series charging.

The invention belongs to the technical field of railway construction, and relates to a control method for realizing the precision of jacking a steel tube arch rib closure based on BIM (building information modeling) technology. According to the control method for realizing the precision of jacking the steel tube arch rib closure based on the BIM technology,the control of precision of jacking the steel tube arch rib closure is realized by adopting the BIM technology and controlling threes factors of the condition before jacking, the condition after in-place jacking and before closure patching,and temperature,the BIM technology of the control method for realizing the precision of jacking the steel tube arch rib closure based on BIM technologyis used for collecting and controllingthree-dimensional deviationintuitive data of an arch support pre-buried steel tube arch rib and a jacking section steel tube arch rib and becomes a decisive factor for realizing the closure precision of an archrib patching section; a"digitization" modeling function with strong BIM technology is used, and actually measured three-dimensional coordinate data provided by a survey crew are utilized; a first twodata comparison of steel tube arch rib closure jacking in the space can be realized through project tab loading; and the 3D visual function is used for intuitively judging the exact position of deviation overrun, and it is ensured that the closure patching precision meets specifications and requirements.

The invention provides an intelligent grid-connected device of a direct-drive wind power generation system.The intelligent grid-connected device comprises a DSP chip, a bus voltage detecting element, an isolated driving circuit, a three-phase power grid current detecting element and a peripheral circuit, wherein bus voltage detecting element, the isolated driving circuit, the three-phase power grid current detecting element and the peripheral circuit are connected with the DSP chip.A control strategy of a wind power grid-connected inverter is a decisive factor of development of grid-connected inverting technology, a current detection circuit and a feedback circuit are not introduced into a traditional control strategy, so that the control mode is slow in dynamic response and sensitive to change of system parameters, a current impacting phenomenon exists, and own development is limited.Therefore, problems of the grid-connected device in the traditional power control strategy are solved based on a direct power control strategy of a virtual flux linkage.

The present invention discloses a simulation optimization platform for a composite micro-energy system, and belongs to the technical field of composite micro-energy simulation. A single simulation module for wireless sensor nodes, lithium batteries, super capacitors, solar cells, and piezoelectric generators is separately established, wherein the simulation module for the lithium batteries also integrates a capacity loss model of the lithium batteries, and a general object-oriented programming method is used to make a system model with great versatility and expansibility. Based on the single modules, a composite micro-energy system model is established, the simulation of environmental changes such as illumination, a wind speed, and the like is carried out, and the simulation mechanism of sensitive events of wireless sensor nodes satisfying the Poisson distribution is established and integrated into the simulation platform of the composite micro-energy system; the range of design parameters of each module that meets the system requirements is obtained; and on this basis, the life of the lithium battery is taken as the decisive factor of the system life, and aiming at extending the system life, the module parameters and energy management methods can be designed and optimized.

The present invention relates to a method for optical catalytic conversion of toluene into chloro-toluene. The method is as follows: first copper chloride and toluene are dissolved in acetonitrile, a cupric chloride and acetonitrile complex can absorb visible light to generate free chlorine radicals, and then on the basis, the free chlorine radicals attack of the toluene to produce benzyl chloride. Compared with non-illumination thermal catalytic reaction, visible light plays a decisive factor in the optical catalytic conversion, and the optical catalytic conversion cannot be separated from the visible light. The benzyl chloride produced by the method has high efficiency, selectivity can reaches more than 95%, and the method is simple, and helps use in the preparation of the benzyl chloride under the visible light.

Disclosed is a method for preventing and treating diabetic gangrenous extremities. A decisive factor of occurrence of diabetic gangrenous extremities is lower limb venous backflow obstruction rather than diabetes. An important adverse factor of frequent lower limb venous backflow obstruction is that lower limb venous blood needs to flow back for more than one meter, which magnifies or even intensifies other adverse factors and makes an original delicate physiological balance difficult to maintain. The important adverse factor is a reality that a person has to face when lower limbs are located in the natural lowest body position. The method for preventing and treating diabetic gangrenous extremities includes temporarily reversing body positions of lower limbs to the highest body position of a human body and implementing exercises so that the vinous blood flows back downwards, original negative factors are temporally converted into positive factors, lower limb venous blood backflow can achieve good effects of upper limb (or even the brain) blood flow, and self-repairing capability of the human body itself can be fully utilized so as to achieve the effect of preventing and treating diseases.

The invention discloses an additive for a positive pole of a lead-carbon battery, which is highly controllable in component and crystal form and a preparation method of a pole plate for the positive pole of the lead-carbon battery. The additive is an alpha / beta-PbO2-SiO2 compound which is prepared by constant-current electrodeposition; the pole plate is prepared from lead powder, alpha / beta-PbO2-SiO2, colloidal graphite and a short fiber. As an excellent electrolyte storage medium, silicon dioxide has certain elastic deformation ability, after being added into the positive role of the lead-carbon battery, while being capable of providing more effective reactive ions for an internal active substance, is used for providing physical buffer action when the pole plate generates deformation, andis used for relieving the phenomenon that lead plaster falls off due to geometrical bending. However, lead dioxide is used as a basic active substance for the positive pole; the crystal form of the lead dioxide is a decisive factor of influencing the electrochemical property of a material. The pole plate prepared from the compound provided by the invention can be used for obviously improving theeffective utilization ratio of an active substance and the corrosion-resistant ability of the pole plate; the falling-off phenomenon in a high-rate partially charged state is effectively relieved, andthe overall energy density and cycle life of the battery are improved.

The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.

Application of a steel pipe with glass lining relates to the steel pipe with glass lining used in delivery pipelines of produced liquid of oil wells. The steel pipes with glass lining are used as the delivery pipelines of the produced liquid of the oil wells for delivering the produced liquid of the oil wells, wherein the produced liquid of the oil wells contains water with ratio of 60%-100%, the delivery temperature is normal temperature, and single pipes of the steel pipes with glass lining delivers the produced liquid of the oil wells. The gathering and transporting technique of the delivery at normal temperature of the glass lining is perfect in application effect, which effectively resolves the problem of deposited paraffin and realizes delivery at normal temperature. The gathering and transporting at normal temperature is realized by employing the steel pipe of glass lining, namely the produced liquid of the oil well need no additional heat source. The produced liquid is delivered at normal-temperature state by employing the dump energy of the oil wells, which can save a large amount of heat energy and electrical energy. The technique is a deciding factor for guaranteeing the delivery at normal temperature to be realized with extremely wide application prospect and remarkable benefits of energy conservation and consumption reduction.