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Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs

A technology of active ingredients and intestinal flora, applied in the field of medicine, can solve the problems of easy oxidation and carcinogenicity of vitamin C and vitamin E

Inactive Publication Date: 2019-03-05
萧湘
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In 2013, the U.S. Food and Drug Administration (FDA) issued a warning on hyperbaric oxygen therapy in the consumer warning section of its website: At present, there is no relevant evidence to prove that hyperbaric oxygen therapy has a clinical therapeutic effect on cancer, autism or diabetes or valid for
[0076] 4. High levels of both gases methane and hydrogen
[0145] 2. Both vitamin C and vitamin E are easily oxidized
[0191] 3. Can inhaling oxygen cause cancer? CA: A Can J Clin: doi: 10.3322 / caac.21208

Method used

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  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs
  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs
  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0259] The preparation of embodiment 1 NDDK prescription 1

[0260] Experimental drugs, instruments and reagents: Oxygen is medical oxygen; instruments are homogenizers; excipients are all pharmaceutical excipients.

[0261] Prescription composition: oxygen, surfactant, thickener, isotonic agent, wall material, water, etc.

[0262] Operation process: Take the prescribed amount of thickener and soak for 12 hours, take another isotonic agent, surfactant, and wall material to dissolve or evenly disperse in water, combine the solutions, add water and / or co-solvent to the required amount, stir, and use hydrogen Adjust the pH value of the sodium oxide solution to 7.3, filter through a 200-mesh steel mesh, sterilize at 121°C for 30 minutes, and cool. Adjust the oxygen to the desired concentration, pass through a 0.22 μm microporous membrane, and pass it into the above-mentioned high-speed stirring solution. A large number of oxygen-containing microcapsules are formed in the solutio...

Embodiment 2

[0271] Embodiment 2: the preparation of NDDK prescription 2

[0272] Prescription 2: 45% oxygen 300ml, poloxamer 13.0g, soybean lecithin 10.0g, sodium chloride 4.0g, polyvinyl acetate phthalate 7.0g, sodium hydroxide solution to adjust pH to 7.6, add water 1000ml.

Embodiment 3

[0273] Embodiment 3: the preparation of NDDK prescription 3

[0274] Prescription 3: 90% oxygen 700ml, poloxamer 17.0g, lecithin 11.0g, glycerin 7.0g, shellac 9.0g, sodium hydroxide solution to adjust pH to 8.1, add water to make 1000ml.

[0275] If the concentration of oxygen is too high, the preparation is easily oxidized, so the oxygen may be mixed with inert gas or other gases. The term "oxygen-comprising gas mixture" also includes pure oxygen.

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Abstract

The invention belongs to the technical field of medicines, and relates to a medicine containing oxygen, a preparation method of the medicine and use of the medicine as a pharmaceutical active ingredient for regulating intestinal microbial communities in preparation of drugs, and particularly to the use of the medicine in preparation of the drugs for preventing or / and treating diseases related to intestinal flora imbalance. The concentration of the oxygen in the environment is a decisive factor for regulating and controlling the distribution structure of microorganisms in the environment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to medicines containing oxygen, a preparation method thereof and their use as medicine active ingredients for adjusting intestinal flora structure in medicine preparation. Specifically relates to the use in the preparation of medicines for preventing or / and treating diseases related to intestinal flora imbalance, including the preparation of medicines for preventing or / and treating obesity, diabetes, hypertension, cancer and Alzheimer's disease use in . Background technique [0002] Oxygen is one of the most important substances in life activities. [0003] Oxygen (O 2 ), the most common elemental form of oxygen. It is not easily soluble in water, accounting for about 21% in the air. Under normal pressure, when the concentration of oxygen exceeds 40%, it may cause oxygen poisoning, and the long-term partial pressure of oxygen (PaO 2 ) in an environment of 60 kPa to 100 kPa (equi...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P1/00A61P3/04A61P3/10A61P9/12A61P25/28A61P33/10A61P35/00
CPCA61K33/00A61K9/50A61P1/00A61P3/04A61P3/10A61P9/12A61P25/00A61P25/28A61P33/10A61P35/00
Inventor 萧湘
Owner 萧湘
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