54results about How to "Boost protein levels" patented technology

The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.

The present disclosure describes high protein snack chips comprising meat, seafood and / or poultry powder that adds animal-sourced protein and / or flavors without entraining problematic moisture in precursor dough used to make the chips. The present disclosure also encompasses methods for producing high protein snack chips comprising the steps of making dough comprising meat, seafood and / or poultry powder along with various dry, wet and, optionally, fat ingredients, sheeting the dough, optionally baking the sheeted dough, cutting the uncooked or baked sheeted dough into pieces, and baking and / or frying the pieces to produce tasty, reduced fat, crispy, crunchy snack chips.

Methods and materials for modulating, e.g., increasing or decreasing, protein levels in plants are disclosed. For example, nucleic acids encoding protein-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased protein levels and plant products produced from plants having increased protein levels.

The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.

Methods and compositions are provided for treating human synovial sarcoma (SS). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma. These methods, compositions, and screens are based on the discovery that promoting the assembly of wild type BAF (also called mSWI / SNF) complexes in SS cells by increasing levels of wild type SS18 and / or decreasing levels of SS18-SSX fusion protein leads to the cessation of proliferation of malignant cells in synovial sarcoma.

The invention relates to proteins for use as a marker for the efficacy of sublingual immunotherapy. In particular, the proteins may be used to predict the responsiveness of a patient to immunotherapy. The invention may find use in selecting patients as suitable candidates for immunotherapy.

The invention discloses a mixed pellet feed directly prepared from optimally-proportioned dry matter of whole-plant corn in a squeezing and extruding mode. The whole-plant corn is mechanically harvested and smashed at the same time, and then is subjected to squeezing dewatering; squeezed-out liquid is concentrated and then is adsorbed with loess, and drying and smashing are carried out; a product is added into a squeezed dry material and the product and the squeezed dry material are mixed evenly; extruding and pelletizing are carried out, and the mixed pellet feed is obtained. The obtained pellet feed is in a yellow green color, is clumpy and does not go mouldy; the moisture content is 7.5-12.8%, the crude protein content is 6-14%, the crude fat content is 1.2-4.7%, the crude fiber content is 43.49-63%, the crude ash content is 21-43%, the nitrite content is 3.1-15.2 mg / kg, and the density is 412-526 kg / m<3>. The nutritional value and the palatability of the pallet feed are both significantly improved, the dry matter and nutritional ingredients in the corn can be preserved in the pallet feed for the longest time, the purposes of timely harvesting, processing, storing and transporting of the feed are achieved, and the feed conversion ratio is greatly increased.

This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to FAD2-like nucleic acid sequences encoding lipid metabolism regulator proteins and the use of these sequences in transgenic plants. In particular, the invention is directed to methods for manipulating lipid metabolism related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel plant polypeptides to stimulate plant growth and / or to increase yield and / or composition of seed storage compounds.

The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.

The invention discloses feed for sows during gestation. The feed is prepared from the following raw materials in percentage by mass: 58% of yellow corn, 4% of alfalfa, 4% of soybeans, 8% of bean pulp, 2% of largeanther senna, 5% of sweet potatoes, 10% of silkworm chrysalis, 3.5% of fish meal, 4% of meat and bone meal, 0.5% of egg-shell powder, 0.3% of salt, 0.3% of calcium carbonate, 0.1% of calcium hydrogen phosphate, 0.2% of vitamin additives, 0.05% of ferrous sulfate, 0.02% of zinc sulfate, 0.01% of lysine, 0.01% of methionine and 0.01% of oxytetracycline. The feed disclosed by the invention is relatively high in energy and protein level, relatively balanced in nutrient, and capable of meeting both the breeding needs and the pig growth needs. The oxytetracycline is used in the formula, so that the immunity of the sows can be improved, the breeding rate can be guaranteed, and the yield-increasing effect can be achieved.

The invention discloses a catfish feed compound enzyme and a preparation method thereof. The preparation method of the catfish feed compound enzyme is characterized by taking nutritional requirement of the catfish and the water environment as the basis, optimizing the raw material formula, combining digestion characteristics of the catfish and scientifically compounding a wine making yeast culture material with functional characteristics such as high nutrition performance, high biological activity, high oxidation resistance and the like, a calcium fruit extract capable of effectively supplementing calcium, iron and soluble fiber, providing powerful embedding effect and prolonging the quality guarantee period of the feed compound enzyme, wormwood seed powder capable of obviously improving anti-freezing effect and stability of the feed compound enzyme, improving water resistance and glossiness of the catfish feed and reducing powder content in the feed, a palatable agent capable of greatly improving palatability and digestion rate of the feed, and wheat malt flour capable of providing rich nutrient materials, biological active materials and plant enzyme sources to finally obtain the catfish feed compound enzyme capable of obviously enhancing digestion rate and parturition performance of the catfish, reducing the feed coefficient, preventing water pollution and maintaining high water quality.

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by omithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

The invention relates to proteins for use as markers for the efficacy of sublingual immunotherapy. In particular, the proteins may be used to predict the responsiveness of a patient to immunotherapy. The invention may find use in selecting patients as suitable candidates for immunotherapy.

The present disclosure provides a method for treating and / or preventing nephrotic syndrome, such as but not limited to minimal change disease and membranous nephropathy, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.