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280 results about "Antibody antigen" patented technology

Analyzing chemical and biological substances using nano-structure based spectral sensing

An integrated chromatography-immunoassay system for integrated chromatography-immunoassay system includes a chromatographic unit that receives labeled nano-structured probes comprising nano particles and antibodies attached to the nano particles, and a test membrane comprising coating antigens. The chromatographic unit allows the labeled nano-structured probes to diffuse there through and into the test membrane, wherein the antibodies on the nano particles are bound to the coating antigens. A laser device emits a laser light to illuminate the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane. A spectral analyzer obtains a Raman spectrum from light scattered from the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane, and to identify a spectral signature in the Raman spectrum associated with the antibody-antigen pair, which enables detection and identification of the antibody.
Owner:EXCELLENT CAPACITY LTD

Preparation method of immune base and antigen or antibody immunoassay method

The invention discloses an immune base preparation method and an antigen or antibody immunoassay method. According to the immune base preparation method, a silicon slice is modified by using gold or silver nanoparticles, and antibodies / antigens are modified on the surfaces of the gold or silver nanoparticles, thereby being used for capturing antigens / antibodies to be assayed. According to the antigen or antibody immunoassay method, an immune base which is prepared by using the immune base preparation method and gold or silver nanoparticle immunoprobes is used, an immune base-antigen / antibody-immunoprobe three-layer sandwich structure is formed through an antigen-antibody immune complex reaction, and the assay on the antigens / antibodies to be assayed is realized in a manner that the characteristic dactylograms of Raman markers on the surfaces of the immunoprobes are assayed by using a surface-enhanced Raman scattering effect of the gold or silver nanoparticles. The method has the advantages that the sensitivity of the immunoassay can be greatly improved and the assay on high-flux multiple antigens / antibodies can be carried out.
Owner:NINGBO UNIV

Methods and assays for detecting GP73-specific autoantibodies

The present invention provides a method for detecting autoantibodies in a subject which reacts with a GP73 antigen. Increased levels of GP73-specific autoantibodies in a sample from the subject which bind to GP73 antigen are indicative of liver disease in the subject.
Owner:INOVA DIAGNOSTICS INC

Captured-antibody competition sandwich immunodetection method capable of extending detection scope and biosensor

The invention discloses a captured-antibody competition sandwich immunodetection method capable of extending detection scope and a biosensor. The captured-antibody competition sandwich immunodetection method is utilized for detecting the concentration of a to-be detected antigen, concretely, the antigen in a to-be detected sample is firstly reacted with a dissociated captured antibody and a marked antibody, and then reacted with an immobilized captured antibody, so that only one complex of marked antibody-antigen-immobilized captured antibody in formed immunization complexes can be detected, and the antigen concentration is determined by measuring the mark signal on the marked antibody of the immunization complex. Because the dissociated captured antibody-antigen-marked antibody complex and the dissociated captured antibody-antigen complex cannot be detected by a detector, the purpose of indirectly diluting the antigen concentration in the to-be detected sample is realized, and the detection scope of the antigen concentration of the to-be detected sample is expanded. Also, the biosensor prepared by utilizing the method has the advantages of wide detection scope, high sensitivity and short detection time.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI

Sensitive and rapid detection of viral particles in early viral infection by laser tweezers

The present system and methods allow for low level detection of as little as single pathogen particles, such as viral or bacterial particles, during the early stage of infection. An optical trapping system, such as laser tweezers, are used to trap a substrate to which an analyte has been bound to detect and record the thermal motion of an antibody-antigen interaction that may occur between an anti-viral antibody-coated microsphere and a viral particle for example. The system may be equipped with a detection system such as a position sensitive photodetector (PSD) to record the thermal motion of a trapped microsphere and particle at a certain frequency. The thermal motion data may be Fourier transformed into a power spectrum, which may be transformed into an output value using a Lorentzian equation. The power spectrum of the trapped microsphere may be recorded before and after binding of the pathogenic particle to determine the presence thereof.
Owner:KENT STATE UNIV

Integration micro-fluidic chip for immune analysis research and applications thereof

The invention discloses an integration micro-fluidic chip for immune analysis research. The chip is mainly composed of a concentration gradient generation unit, an equal allocation unit and a micropore reaction chamber matrix with the diameter of 5.8mm and the depth of 100 mu, and has small volume and large specific surface area; the arrangement of the micropore reaction chamber matrix is consistent with the arrangement of a traditional porous plate, and the micropore matrix can be applied to a standard microplate reader for detecting and gathering analysis data. According to the invention, the operations of absorption and fixation of antibodies, antigens and enzyme during immune analysis operation, the preparation of sample solutions with different concentrations, liquid replacement, washing and the other operations are all integrated on a chip and are completed automatically according to the process creatively; the reagent consumption can be lowered obviously; the analysis time can be shortened; and the efficiency can be improved. Compared with the traditional porous plate technology, according to the invention, the complex manual operations of sample solution preparation, washing and the like are omitted, and the integration micro-fluidic chip for immune analysis research is compatible with the standard microplate reader on the detecting method.
Owner:SUN YAT SEN UNIV

Single-index microfluidic chip, and production method and application method thereof

The invention discloses a single-index microfluidic chip, and a production method and an application method thereof. The single-index microfluidic chip comprises a chip body. A sampling cavity, a quantitative reaction cavity and a waste liquid cavity are formed in the chip body; a first backflow prevention device and a second backflow prevention device are arranged at the front end and the rear end of the quantitative reaction cavity correspondingly; at least one of the first backflow prevention device and the second backflow prevention device is a rubber plug anti-backflow device that comprises a rubber plug, a fluid input pipe capable of raising the fluid delivery height and a fluid output pipe capable of lowering the liquid delivery height. The front end and the rear end of the quantitative reaction cavity are provided with the backflow prevention devices, and accordingly, quantification of fluids in the quantitative reaction cavity can be guaranteed; during antibody / antigen coating, antibody / antigen coating solvents can be injected into the fluid input pipe / fluid output pipe of the rubber plug anti-backflow device, and then are subjected to incubation, washing, packaging, and vacuumizing by a vacuum drying oven before being provided with a rubber plug, so that the single-index microfluidic chip is suitable for mass production. Basically, the quality of coated antibodies / antigens is not affected by the packaging time and the packaging process.
Owner:NANJING LANSION BIOTECH CO LTD
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