32 results about "2-naphthaldehyde" patented technology

The present invention relates to a new synthetic method of nafamostat mesylate intermediate - 6-amidino-2-naphthol mesylate. The new method uses 6-hydroxyl-2-naphthaldehyde as a raw material, and uses dimethyl sulfoxide as a reaction solvent to react with hydroxylamine hydrochloride for addition and elimination to obtain 6-cyano-2-naphthol, 6-cyano-2-naphthol A pinner reaction occurs in HCl / methanol solution to obtain 6-hydroxyl-2-naphthiminomethyl ester hydrochloride, and then feed ammonia to carry out ammonolysis reaction to obtain 6-amidino-2-naphthol, 6-amidino ‑2‑naphthol is successively reacted with sodium bicarbonate and methanesulfonic acid to be converted into 6‑amidino‑2‑naphthol mesylate. In the new synthetic method, the preparation of the first step 6-cyano-2-naphthol adopts a brand-new method, which avoids the use of highly toxic copper cyanide in the traditional method, and is simple to operate and mild in condition; the second step adopts an improved The pinner method uses the reaction of acetyl chloride and methanol to generate HCl instead of directly passing HCl gas into the reaction system. The improved method is more operable and easier to realize industrialization.

The invention provides a fluorescent probe for detecting cysteine. The probe has the chemical structural formula shown in the specification. The probe can be obtained by carrying out a reaction of thereaction product of 9,10-phenanthrenequinone, 6-hydroxy-2-naphthaldehyde and ammonium acetate with acryloyl chloride. The probe can realize the high sensitivity and high selectivity of a cysteine probe, and can be used as an indicator for indicating the change of cysteine in an aqueous solution and inside biological cells, and can perform the real-time qualitative and quantitative visual colorimetry detection. The probe is a simple, rapid and sensitive cysteine specific detection reagent, and has broad application prospects in the biomolecule detection field.

The invention belongs to the field of organic chemistry, and in particular relates to 6'-hydroxyl naphthyl-2-cyanoacrylate. The chemical structure of the 6'-hydroxyl naphthyl-2-cyanoacrylate is shown in formula (I) which is as shown in the description, wherein R is methyl, ethyl, propyl and butyl, 2-(2-methoxy ethyoxyl) ethyoxyl or 2-(N,N-dimethyl) aminoethyl. The 6'-hydroxyl naphthyl-2-cyanoacrylate is obtained by performing reaction on 6'-hydroxyl-2-naphthaldehyde and 2-cyan-acetic ester. The 6'-hydroxyl naphthyl-2-cyanoacrylate has fluorine ion fluorescence recognition performance and can be used for detecting fluorine ions in cells.

The invention provides a fluorescent probe for bivalent copper ions and a preparation method of the fluorescent probe. The method comprises the steps of dissolving 6-methoxyl-2-naphthaldehyde in a reaction flask by taking methanol as a solvent, and heating up to 40-50 DEG C; dissolving carbohydrazide by taking water as a solvent, then dropwise adding the dissolved carbohydrazide into the reaction flask, and carrying out reflux reaction for 3h; after the reaction, filtering and drying a mixed solution for removing the solvents to obtain the Schiff base fluorescent probe for the copper ions. The method is simple in operation, convenient and fast, low in cost of a needed intermediate and easy in control of reaction process; the product is easy to separate, high in yield and high in purity. The fluorescent probe has special recognition performance for the copper ions, thus having wide application prospect in the aspects of sensor technologies, photochemistry, electroluminescent devices, and the like.

The invention provides a target and fluorescence color variable fluorescence probe and application thereof in distinguishing of imaging dead and living cells. A chemical name of the fluorescence probeis 2-(6-methoxy-6-naphthylvinyl)-N-methyl-quinoline iodate. The fluorescence probe is synthesized by steps: using 2-methylquinoline and iodomethane to synthesize 1,2-dimethylquinoline iodate; subjecting the 1,2-dimethylquinoline iodate and 6-methoxy-2-naphthaldehyde to condensation reaction at the room temperature to generate a product by taking pyrrolidine as a catalyst. The synthesis method ofthe probe is simple, dead and living cells can be distinguished and marked by two fluorescence colors and two dyeing positions, and a promising application prospect is achieved.

The invention relates to a cyclization reaction of myrac aldehyde catalyzed by tungsten carbide, specifically to a method of selective cyclization of myrac aldehyde catalyzed by supported tungsten carbide for preparation of cyclic myrac aldehydes. According to the method, para- / meta- myrac aldehyde is used as a raw material to undergo a highly selective reaction in an organic solvent at 50-150 DEGC to generate cyclic myrac aldehydes 1,2,3,4,5,6,7,8-octahydro-,8,8-dimethyl-2-naphthaldehyde and 1,2,3,4,5,6,7,8-octahydro-5,5-dimethyl-2-naphthaldehyde. The conversion rate of the substrate reachesup to 100%, and yield of the target product reaches up to 99%. Compared with the conventional catalytic route, the supported non-noble metal tungsten carbide is used as a catalyst without the use ofinorganic acid or alkali in the invention, thus avoiding generation of a large amount of acid liquor by traditional catalysis. The invention has the following characteristics: the reaction condition is mild; the catalyst is cheap and recyclable and has high activity and selectivity; and the reaction process is environmentally-friendly.

The invention discloses a cyanide receptor compound based on 2-cyano-3-(6-N, N-dimethylamino-2-naphthyl) acrylonitrile, a preparation method and application thereof. The compound takes a C=C double bond as a reactive binding site and takes 6-N, N-dimethylamino-2-naphthaldehyde as a fluorescence signal reporter group. When a receptor encounters cyanide ions, the cyanide ions and the C=C double bond of the receptor can carry out addition reaction so as to cause proton transfer and charge transfer in receptor molecules, so that the receptor molecules have color and fluorescence changes. The invention respectively researches the identification effects of the compound to F<->, Cl<->, Br<->, I<->, Ac<->, H2PO4<->, HSO4<->, ClO4<-> and CN<-> through colorimetry, ultraviolet-visible absorption spectroscopy and fluorescent spectrometry. The results show that the receptor compound can singly and selectively identify cyanide ions in an HEPES-DMSO-H2O system and has very high sensitivity to detection of CN<->.

The invention relates to a dehydroepiandrosterone aromatic aldehyde azine steroidal compound with an azine structure. The chemical structural formula is as shown by dehydroepiandrosterone acetone azine (1), dehydroepiandrosterone benzaldehyde azine (2), dehydroepiandrosterone-3-pyridylaldehyde azine (3), dehydroepiandrosterone-3-thiophenecarboxaldehyde azine (4), dehydroepiandrosterone-3-hydroxybenzaldehyde azine (5), dehydroepiandrosterone-2-naphthaldehyde azine (6), dehydroepiandrosterone-4-quinolinecarboxaldehyde azine (7) and dehydroepiandrosterone-6-methoxy-naphthaldehyde azine (8) described in the specification. Experiments prove that the dehydroepiandrosterone aromatic aldehyde azine steroidal compound has an obvious inhibitory effect on various tumor cell strains, and can be applied to preparation of drugs for treating cancers.

The invention discloses a synthesis method of high-temperature-resistant polyarylene ether nitrile resin. The synthesis method is characterized by comprising the following steps: placing 2-naphthaldehyde, 2,6-xylenol and toluene in a reaction kettle, dropwise adding a sulfuric acid aqueous solution and 3-thiohydracrylic acid under nitrogen atmosphere, heating and concentrating after washing by deionized water and toluene, separating out a crystal and drying to obtain a bisphenol functional monomer; adding 2,6-dichlorobenzonitrile, a diphenol monomer, the bisphenol functional monomer, anhydrous potassium carbonate, N, N-dimethylpyrrolidine and toluene to the reaction kettle, carrying out heat preservation to obtain a polycondensation product; adding the polycondensation product to deionized water or the sulfuric acid aqueous solution to be boiled, performing suction filtration, washing a solid by deionized water and then drying the solid to prepare the high temperature resistant polyarylene ether nitrile resin. According to the invention, the bisphenol monomer of which the side group contains a naphthalene ring structure is introduced into molecules of the traditional polyarylene ether nitrile, so that the prepared polyarylene ether nitrile resin has good heat resistance and processing properties.