The invention relates to a commonly used
drug spermicide for contraception, in particular to biodegradable contraception gel with
antibacterial effect, and belongs to an autonomous external contraceptive. On the basis of the biodegradable contraception gel, exact quantitative administration can be realized by virtue of a disposable long cylinder applicator. The antibacterial contraception gel is composed of a spermicide, biodegradable gel and water. The gel is specifically
vaginal gel compounded by silk
fibroin and
chitosan and comprises the following components in
mass concentration: 2-8% ofsilk
fibroin, 0.5-2% of
chitosan, 0.5-2% of carbomer 940 or hydroxypropyl
methyl cellulose, 5-12% of
glycerol and
propylene glycol and the balance of water, and pH value is regulated to be 3.5-5. Theproduct can achieve the effects of rapidly killing sperms and carrying out contraception and birth control, also has
antibacterial effect and can prevent and alleviate germ infection in
genital tract.Ingredients of the gel are biodegradable, and degradation products can be absorbed and have the effect of alleviating
vaginal dryness and
atrophy to some extent. The
gel preparation fills a needle tube type tool and can be directly injected deep inside a
vagina, and the aim of the exact quantitative administration is achieved. The product has good
biocompatibility, can not influence pH of the
vagina, has no
side effect and is worthy of being popularized and applied in clinic.