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Medical toothpaste including sodium azulene sulfonate

A technology of sodium azulene sulfonate and toothpaste, applied in dentistry, medical science, pharmaceutical formulation and other directions, can solve problems such as weak antibacterial effect, and achieve good preventive and therapeutic effects.

Active Publication Date: 2011-06-08
天津顶硕药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pharmacological studies on sodium azulene sulfonate have shown that sodium azulene sulfonate has non-steroidal anti-inflammatory effects and anti-mucosal ulcer effects. The main pharmacological effects are: anti-inflammatory, promotion of mucosal metabolism, epidermis formation, but the antibacterial effect is very weak

Method used

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  • Medical toothpaste including sodium azulene sulfonate
  • Medical toothpaste including sodium azulene sulfonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: (unit gram)

[0018] Calcium bicarbonate 49

[0019] Carboxymethylcellulose 1.2

[0020] Saccharin 0.3

[0021] Glycerin 25

[0022] Sodium Lauryl Sulfate 3

[0023] Sodium pyrophosphate 1

[0024] Distilled water 19.2

[0025] Fragrance 1.3

[0026] Sodium azulene sulfonate 0.02

[0027] Honeysuckle Extract 3

[0028] Bamboo Leaf Extract 2

Embodiment 2

[0029] Embodiment 2: (unit gram)

[0030] Calcium hydrogen phosphate anhydrous 2

[0031] Calcium hydrogen phosphate dihydrate 45

[0032] Methylcellulose 1

[0033] Saccharin 0.4

[0034] Glycerin 10

[0035] Sorbitol 10

[0036] Sodium Lauryl Sulfate 2

[0037] Distilled water 28.6

[0038] Fragrance 1

[0039] Sodium azulene sulfonate 0.025

[0040] Honeysuckle Extract 4

[0041] Bamboo Leaf Extract 3

Embodiment 3

[0042] Embodiment 3: (unit gram)

[0043] Calcium carbonate 40

[0044] Saccharin 0.2

[0045] Glycerin 15

[0046] soap flakes 10

[0047] starch 5

[0048] Spice 1

[0049] Distilled water 28.8

[0050] Sodium azulene sulfonate 0.03

[0051] Honeysuckle Extract 5

[0052] Bamboo Leaf Extract 4

[0053] Curative effect observation:

[0054] In order to observe the curative effect of the drug toothpaste added with sodium azulene sulfonate and traditional Chinese medicine ingredients, guinea pigs artificially induced to suffer from gingivitis were used for the experiment. Healthy guinea pigs were selected and raised at room temperature for one week, with a body weight of 250 g to be used in experiments. The test was divided into 4 groups, 25 guinea pigs in each group, and 4 parts of the gums of guinea pigs were wounded with needles to create artificial gingivitis. After 24 hours of inflammation, the inflammation was observed by the degree of swelling. The degree of ...

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Abstract

The invention discloses a pharmaceutical toothpaste, wherein each 100g of the toothpaste base material contains sodium azulenesulfonate 0. 01-1g and 0. 1-20% of Chinese herbal constituents including honeysuckle flower, capsule of weeping forsythia, isatic root, dandelion, Philippine violet herb, wild chrysanthemum flower, purslane, cortex dictamni radicis,Chinese olive, bamboo leaves, green tea, mentha and mulberry leaf.

Description

technical field [0001] The invention relates to a toothpaste, in particular to a medicated toothpaste containing sodium azulene sulfonate which can obviously reduce or eliminate symptoms of oral diseases such as gingivitis, periodontitis, alveolar abscess and oral ulcer. Background technique [0002] The periodontal support tissue in the oral cavity is subject to local stimulation, such as calculus, food impaction, bad restorations, etc., long-term mechanical stimulation, irregular dentition, excessive occlusal force burden on some teeth, incorrect tooth brushing methods, and chemical drugs , burns, vitamin C deficiency, and bacterial growth in the oral cavity can cause common oral diseases such as gingivitis, periodontitis, and alveolar abscess. [0003] At present, there are many drug toothpastes for the treatment of common oral diseases in the domestic market, which mainly contain traditional Chinese medicine toothpaste. Traditional Chinese medicine toothpaste is based o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/46A61Q11/00
Inventor 许荧
Owner 天津顶硕药业股份有限公司
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