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Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof

A chlorine dioxide and cetyl pyridinium chloride technology, applied in the field of mouthwash, can solve the problems of inability to use for a long time, destroy the ecological balance of the oral cavity, and the breath will rebound, and achieve the effects of inhibiting bacterial plaque, long-term effective breath, and reducing the breath value.

Inactive Publication Date: 2010-07-21
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs with antibacterial effects such as chlorhexidine and metronidazole have certain curative effects, but long-term use can destroy the ecological balance of the oral cavity and easily cause bacteria to develop drug resistance, so they cannot be used for a long time
The use of drugs that can convert the volatile sulfide gas in the breath into non-volatile substances, such as chlorine dioxide, zinc ions, hydrogen peroxide, etc., can only relieve the breath in a short period of time. will rebound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The raw materials are cetylpyridinium chloride, zinc acetate and chlorine dioxide as main components, and the auxiliary materials are menthol, 95% ethanol, glycerin, distilled water and sodium saccharin.

[0014] Accurately weigh 0.5g of cetylpyridinium chloride, 2.5g of zinc acetate and 0.15g of sodium saccharin, dissolve them in about 300ml of distilled water, and weigh 0.2g of menthol and dissolve them in 30ml of 95% ethanol, and add the menthol ethanol solution into the aqueous solution Stir, add 40ml of glycerin in the same way; and accurately weigh 2.86g of chlorine dioxide powder, dissolve it in about 80ml of distilled water, add the aqueous solution of chlorine dioxide into the aqueous solution, stir while adding, mix well, add distilled water to 500ml, mix well Promptly obtain the composite formula mouthwash.

Embodiment 2

[0016] The raw materials are cetylpyridinium chloride, zinc acetate and chlorine dioxide as main components, and the auxiliary materials are menthol, 95% ethanol, glycerin and distilled water.

[0017] Accurately weigh 0.5g of cetylpyridinium chloride and 2.5g of zinc acetate, dissolve them in about 300ml of distilled water, and weigh another 0.2g of menthol and dissolve them in 30ml of 95% ethanol, add the menthol ethanol solution into the aqueous solution and stir, and add in the same way 40ml of glycerin; in addition, accurately weigh 2.1g of chlorine dioxide powder, dissolve it in about 80ml of distilled water, add the chlorine dioxide aqueous solution into the aqueous solution, stir while adding, mix well, add distilled water to 500ml, and mix well to obtain the compound formula gargle saliva.

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Abstract

The invention relates to compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and a preparation method thereof. The compound formula mouth wash comprises the following main raw materials: chlorine dioxide, cetylpyridinium chloride and zinc ions, wherein a solvent is distilled water; the concentration of the chlorine dioxide is 200-500 ppm; the cetylpyridinium chloride accounts for the mass fraction of 0.05-0.2 percent relative to the compound formula mouth wash; and the zinc ions accounts for the mass fraction of 0.5-1 percent relative to the compound formula mouth wash. The preparation method of the compound formula mouth wash comprises the following steps of: dissolving the cetylpyridinium chloride and zinc acetate into the distilled water; dissolving a menthol crystal into 95 percent of ethanol; adding a menthol crystal and ethanol solution to a water solution for stirring, and simultaneously adding glycerol; additionally dissolving chlorine dioxide powder into the distilled water; adding a chlorine dioxide water solution to the water solution while stirring; uniformly stirring, and adding the distilled water to obtain the compound formula mouth wash of the chlorine dioxide, the cetylpyridinium chloride and the zinc ions. The invention can effectively inhibit bromopnea for a long time and has fewer side effects and no obvious irritation on an oral mucosa.

Description

【Technical field】 [0001] The invention relates to the technical field of mouthwash, in particular to a compound formula mouthwash of chlorine dioxide, cetylpyridinium chloride and zinc ions and a preparation method thereof. 【Background technique】 [0002] Bad breath is a common oral symptom, which is caused by a series of factors inside and outside the oral cavity, but in most cases, bad breath originates from the oral cavity itself, which is attributed to the production of a series of amino acids by anaerobic bacteria in the oral cavity under anaerobic conditions. The product, the main component is volatile sulfide gas. At present, there are two main types of drugs for the treatment of bad breath. The first is drugs that can reduce the number of anaerobic bacteria in the oral cavity. Commonly used chlorhexidine, metronidazole, cetylpyridinium chloride, and triclosan have antibacterial effects. etc.; followed by drugs that can convert the volatile sulfide gas in the breath ...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/22A61K8/36A61Q11/00
Inventor 叶玮李允武冯希平
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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