41results about How to "The reaction process is mild and easy to control" patented technology

The invention provides a method for synthesizing a phenol derivative having a phosphorous chiral center and containing a (Rp)-2-chiral phosphinate substituent in a high stereoselectivity manner. According to the method, with small organic molecules as a catalyst and a (Rp)-2-chiral phosphinate compound containing P-H bonds, and phenol as reaction substrates, an organic solvent is added into a reaction system. The method has the advantages that the catalyst is low in cost and easy to obtain; reaction conditions are mild, safe and reliable; the stereoselectivity of the obtained target product is close to 100 percent and the yield of the obtained target product is up to 90 percent. According to the method provided by the invention, the defects of poor stereoscopic enantioselectivity, fussy reaction steps, low yield and the like of an organic phosphine compound containing the phosphorous chiral center, which is synthesized by adopting a traditional method, are overcome, and the method has a favorable industrial prospect. The invention further provides the phenol derivative having the phosphorous chiral center and containing the (Rp)-2-chiral phosphine substituent.

The invention provides a method for efficiently synthesizing an alpha-acyloxy ketone compound containing different substitute functional groups. According to the method, acetylacetone copper is taken as a reaction catalyst, t-butylhydroperoxide is taken as an antioxidant, ketone compounds and terminal alkyne compounds are taken as reaction substrates, and an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easily available; reaction conditions are mild, safe and reliable; and the productivity of an obtained target product is relatively high. According to the method, the problem that a traditional alpha-acyloxylation reaction system is single is solved, and a novel acyloxylation reagent is provided; and the method has good industrial application prospects.

The invention provides a method for synthesizing phenol derivatives containing (Sp)-2-chiral phosphinate substituent groups with a phosphorus chiral center at high stereoselectivity. The method is characterized in that an organic small molecule material is taken as a catalyst, (Rp)-chiral phosphinate compounds containing a P-H bond and 2-halogenated phenol (-I, -Br) are taken as reaction substrates, and a base and an organic solvent are added to a reaction system. The method provided by the invention has the following advantages that the catalyst is cheap and easy to obtain, the reaction conditions are mild, and safe and reliable, the stereoselectivity of the obtained target product is close to 100% and the yield of the product is high; and the method overcomes the shortcomings of poor stereo enantioselectivity, complex reaction steps, low yield and the like of the traditional method for synthesizing a chiral phosphine compound with the phosphorus chiral center, and has an excellent industrial application prospect. The invention also provides phenol derivatives containing the (Sp)-2-chiral phosphinate substituent groups with the phosphorus chiral center.

The invention provides a method for efficiently and highly selectively synthesizing diarylmethylphosphonate derivatives containing different substituted functional groups. According to the method, silver tetrafluoroborate is used as a catalyst, trialkyl phosphite and a 4-arylmethylene-2,6-di-tert-butyl-2,5-cyclohexadien-1-one compound are used as reaction substrates, and an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easily available; substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of the obtained target products is close to 100%; and the yield of the target products is as high as 90% or above. The method overcomes the defects of poor reaction selectivity, complex reaction steps, low yield, need for reagents harmful to the environment and the like in traditional synthesis of diarylmethyl substituted phosphonate derivatives, and has favorable industrial application prospects. The invention also provides the corresponding diarylmethyl substituted phosphonate derivatives containing different substituted functional groups at the same time.

The invention provides a recovery method of protein in high concentration protein wastewater. Nitrogen circulation carries acetic acid into high concentration protein wastewater to adjust pH change step by step to different protein isoelectric points (pI), thus achieving graded isoelectric precipitation and recovery of protein from wastewater. The method provided by the invention adopts carry of acetic acid by pressurized nitrogen circulation as an acidic adjustment means, makes the pH value adjustment mild and controllable, can precipitate out proteins with different isoelectric points under different operation conditions respectively, thereby achieving the purpose of efficient and graded removal of protein from high concentration protein wastewater by protein isoelectric point precipitation technique.

The invention provides a high-efficiency and high-selectivity synthetic method for organic phosphate derivatives containing different substituted functional groups. The method uses tetrabutylammoniumiodide as a catalyst and uses a P(O)-OH-containing compound and a methyl-containing aromatic hydrocarbon compound as reaction substrates, and an organic solvent and an oxidant are added in the reaction system. The method has the advantages that the catalyst is cheap and easy to obtain, the substrate applicability is high, the reaction conditions are mild, safe and reliable, the selectivity of an obtained target product is close to 100%, and the yield is up to 90% or more. The method solves shortages in traditional organic phosphate ester compound synthetic methods that reaction selectivity ispoor, reaction steps are complicated, the yield is low, environmentally-harmful agents are used and the like, and has better industrial application prospects. The invention also provides the corresponding organic phosphate derivatives containing the different substituted functional groups.

The invention provides a method for preparing organic lactone. The method is characterized in that carbon materials are used as catalyst, the carbon materials may be graphite, graphene, carbon nano tube, active carbon and so on; organic ketone is used as substrate, oxygen or air is used as oxygen source, organic aldehydes materials are used as reductant, and organic solvent is added into reaction system. The method has the following advantages: the preparation for the catalyst is simple; the reaction condition is mild, secure, credible and environmental friendly; the selectivity and the yield of the obtained target products are about 100%; and the catalyst can be used repeatedly. The method solves the problem that the traditional preparation technology for lactone has poor security and low yield, and has good industrial application prospect.

The invention provides a method for efficiently and highly selectively synthesizing 2-diarylmethyl substituted-1-naphthol compounds containing different substituted functional groups, which adopts phosphoric acid as a catalyst, adopts 1-naphthol compounds and 4-arylmethylene-2, 6-dialkyl-2, 5-cyclohexadiene-1-ketone compounds as reaction substrates, and adopts a one-pot method to synthesize the 2-diarylmethyl substituted-1-naphthol compounds containing different substituted functional groups. The reaction system takes water as a solvent. The method has the advantages that the catalyst is cheap and easily available; the substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is high. The method overcomes the defects of poor reaction selectivity, tedious reaction steps, low yield, need of reagents harmful to the environment and the like in traditional synthesis of the 2-diarylmethyl substituted-1-naphthol compound, and has a good industrial application prospect. The invention also provides the corresponding 2-diarylmethyl substituted-1-naphthol compounds containing different substituted functional groups at the same time.

The invention provides a method for efficiently synthesizing derivatives which contain different substitution functional groups and have C2-position alkynyl substituted.According to the method, Pd(OAc)2(PPh3)2 / CuI is used as a catalyst, Na2CO3 is added as alkaline, compounds containing thiamine and terminal alkyne are used as oligomer, and organic solvent is added to the reaction system.The method has the advantages that the catalyst is low in price and easy to obtain; the reaction condition is mild, safe and reliable; the highest yield of target products reaches 92%.The method overcomes the defects that in traditional desulfuration reaction, cuprous thiophene needs to be used as a desulfurizing agent and cuprous halides can not react; the operation process is simple, and good industrial application prospects are achieved.

The invention provides a new method for efficiently and highly selectively synthesizing 2'-iodo[1,1'-biaryl]-2-organophosphonate compounds containing different functional groups, which uses cheap transition metal copper The salt is used as a catalyst, and the compound containing P(O)-OH and bisaryltrifluoromethanesulfonic acid periodiodium salt is used as a reaction substrate, and an organic solvent and a base are added to the reaction system. The advantages of the method are: the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as more than 90%. The method solves the shortcomings of the traditional synthesis of 2'-iodo[1,1'-biaryl]-2-organophosphonate compounds, such as poor reaction selectivity, cumbersome reaction steps, low yield, and the need to use environmentally harmful reagents. , has good industrial application prospects. The present invention also provides corresponding 2'-iodo[1,1'-biaryl]-2-organophosphonate derivatives substituted with different functional groups.

The invention provides a method for efficiently and high-selectively compounding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives containing different substituting functional groups. Cesium carbonate is taken as a catalyst; chiral P(O)-H compound and 4-aryl methylene-2,6-di-tert-butyl-2,5-cyclohexadiene-1-ketone compounds are taken as reaction substrates; an organic solvent is added into a reaction system. The method has the advantages that the catalyst is low-cost and can be easily acquired; the substrates are high in applicability; the reaction conditions are mild, safe and reliable; the three-dimensional enantioselectivity of the acquired target product is above 99% and the yield is above 80%. The method can overcome the defects of low enantioselectivity, complex reaction steps, and the like, of the traditional reaction for compounding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives, can avoid the traditional chiral resolution method and has an excellent industrial application prospect. The invention also provides the corresponding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives containing different substituting functional groups.

The invention discloses aromatic primary diamine containing a triaryl-s-triazine structure and an ether bond and a preparation method thereof, belonging to the technical field of synthesis of compounds. The aromatic primary diamine containing the triaryl-s-triazine structure and the ether bond has a structural formula as shown in a formula (I). The preparation method comprises the following steps: subjecting a dihalogen compound containing triaryl-s-triazine and shown in a formula (II) and a p-aminophenol compound as shown in a formula (III) to a nucleophilic substitution reaction; and then subjecting a reaction product to filtering, washing and drying so as to obtain the aromatic primary diamine containing the triaryl-s-triazine structure and the ether bond. The aromatic primary diamine containing the triaryl-s-triazine structure and the ether bond in the invention contains the triaryl-s-triazine structure with high rigidity, high thermal stability and strong polarity, so when the aromatic primary diamine is used as a monomer for synthesis of polyamide, polyimide and benzoxazine resin, the aromatic primary diamine can effectively improve the heat resistance and mechanical properties of a material and reduce the dielectric loss and water absorption rate of the material at the same time.

The invention provides a method for synthesizing diarylmethylphosphonate derivatives containing different substituted functional groups with high efficiency and high selectivity. The method adopts silver tetrafluoroborate as a catalyst, and uses trialkyl phosphite and 4- Arylmethylene-2,6-di-tert-butyl-2,5-cyclohexadiene-1-ketone compounds are used as reaction substrates, and an organic solvent is added to the reaction system. The advantages of this method are as follows: the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90%. The method solves the shortcomings of traditional synthesis of diarylmethyl substituted phosphonate derivatives, such as poor reaction selectivity, cumbersome reaction steps, low yield and the need to use environmentally harmful reagents, and has good industrial application prospects. The present invention also provides corresponding diarylmethyl substituted phosphonate derivatives with different substituted functional groups.

The invention provides a high-efficiency and high-selectivity synthetic method for organic phosphate derivatives containing different substituted functional groups. The method uses tetrabutylammoniumiodide as a catalyst and uses a P(O)-OH-containing compound and a methyl-containing aromatic hydrocarbon compound as reaction substrates, and an organic solvent and an oxidant are added in the reaction system. The method has the advantages that the catalyst is cheap and easy to obtain, the substrate applicability is high, the reaction conditions are mild, safe and reliable, the selectivity of an obtained target product is close to 100%, and the yield is up to 90% or more. The method solves shortages in traditional organic phosphate ester compound synthetic methods that reaction selectivity ispoor, reaction steps are complicated, the yield is low, environmentally-harmful agents are used and the like, and has better industrial application prospects. The invention also provides the corresponding organic phosphate derivatives containing the different substituted functional groups.

The invention provides a method for efficiently and highly selectively synthesizing 2-iodine-1-phosphoryl substituted alkane compounds containing different functional groups. N ‑Iodosuccinimide (NIS) is used as an accelerator, P(O)‑OH-containing compounds and olefins are used as reaction substrates, and an organic solvent is added to the reaction system. The advantages of this method are: the accelerator is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90%. This method develops a new way to synthesize substituted 2-iodo-1-phosphoryl substituted alkane compounds containing different functional groups, and solves the problems of poor reaction selectivity, cumbersome reaction steps, It has the disadvantages of low yield and the need to use harmful reagents to the environment, and has good industrial application prospects. The present invention also provides corresponding 2-iodo-1-phosphoryl substituted alkane derivatives substituted with different functional groups.

The invention provides a method for preparing organic lactone. The method is characterized in that: a load type catalyst Co-MFI having a hexagonal prism morphology is used as a catalyst, and the catalyst is prepared by a method of hydrothermal crystallization synthesis; organic ketone is used as a substrate, oxygen or air is used as oxygen sources, organic aldehyde substances are used as reducing agents, and an organic solvent is added into a reaction system. The method has the advantages that: the catalyst is easy to prepare; the reaction conditions are mild, safe, reliable, green and environment-friendly; the selectivity and the yield of target products approach to 100 percent; and the catalyst can be repeatedly recycled. According to the method, the problems of low safety, low yield and the like in the conventional preparation process of the lactone are solved, and the method has a good industrial application prospect.

The invention provides a method for preparing phosphoryl azo compounds with high efficiency and high selectivity; pyridine is used as alkali, an aryl diazonium tetrafluoroborate compound and a P(O)-Hcompound are used as reaction substrates, and an organic solvent is added into a reaction system. The method has the advantages that a catalyst is cheap and easily available; the substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of the obtained target products is close to 100%, and the yield is high. The method overcomes the defects of harsh reactionconditions, poor reaction selectivity, complex experimental steps, low yield, need of reagents harmful to the environment and the like in a traditional synthesis of phosphoryl azo compounds, and hasfavorable industrial application prospects. The invention also provides the corresponding phosphoryl azo compounds containing different substituted functional groups.

The invention provides a method for preparing organic lactone. The method is characterized in that: cubic cobaltosic oxide is taken as a catalyst, and the catalyst is prepared with a hydrothermal method; and organic ketone is taken as a substrate, oxygen or air is taken as an oxygen source, an organic lactone substance is taken as a reducing agent, and an organic solvent is added into a reaction system. The method has the advantages that: the catalyst is easy to prepare; reaction conditions are mild, and the method is safe, reliable and environmentally-friendly; the selectivity and yield of an obtained target product are close to 100 percent; and the catalyst can be used for repeatedly. Due to the adoption of the method, the problems of poor safety, low yield and the like existing in the conventional lactone preparation process are solved, and the method has a good industrial application prospect.

The invention provides a method for efficiently and highly selectively synthesizing o-diaryl phosphoryl-substituted phenolic derivatives containing different functional groups, which uses water as a catalyst to synthesize diaryl derivatives containing P(O)-H bonds The phosphorus oxy compound and the 4,4-dimethoxy-2,5-cyclohexadiene-1-ketone compound are used as reaction substrates, and an organic solvent is added to the reaction system. The method has the advantages that the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction condition is mild, safe and reliable; the yield of the obtained target product is as high as more than 90%. The method solves the shortcomings of traditional synthesis of o-diaryl phosphoryl substituted phenol derivatives such as poor reaction selectivity, cumbersome reaction steps, low yield, and the need to use harmful reagents to the environment, and has good industrial application prospects. The present invention also provides corresponding o-diaryl phosphoryl substituted phenol derivatives containing different functional groups.

The invention provides a method for efficiently and selectively synthesizing diaryl methyl substituted organic phosphonate derivatives containing different substitute functional groups. The method uses cesium carbonate as a catalyst, and uses a P (O)-H compound and 4-arylmethylene-2, 6-di-tert-butyl 2, 5-cyclohexadiene-1-ketone compounds as reactants; an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easy to obtain; the reactants are high in applicability; the reaction is mild in conditions, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90% or above. The method solves the problems that the conventional synthetic diaryl methyl substituted organic phosphonate derivatives are poor in reaction selectivity, tedious in reaction steps and low in yield, needs to use environmentally harmful reagents, and the like; the method has a good industrial application prospect.The invention also provides the corresponding diaryl methyl substituted organic phosphonate derivatives containing the different substitute functional groups.

The invention provides a method for preparing an organophosphate compound through efficient esterification of a P(O)-OH-containing compound and phenol. The method realizes efficient and highly selective synthesis of organophosphate derivatives containing different substituted functional groups. A carbonyl diimidazole compound is used as a condensation reagent, a P(O)-OH-containing compound and phenol are used as reaction substrates, and an organic solvent is added into the reaction system. The catalyst is cheap and easy to acquire, the applicability to the substrate is high, the reaction conditions are mild, safe and reliable, the selectivity of the target product is close to 100% and the yield is 90% or more. The method solves the problem that the traditional method for synthesis of an organophosphate compound containing an aromatic functional group has poor reaction selectivity, complex reaction steps and a low yield, needs reagents harmful for the environment, and has good industrial application prospects. The invention also provides an organophosphate derivative containing different aromatic group substituents.

The invention discloses a size-controllable Schiff base-type polymer nano-particle, which is prepared through a Schiff base reaction to 2,6-diaminopyridine and formalin, wherein molar ratio of the 2,6-diaminopyridine to formaldehyde in the formalin is 1:2-18. The invention also provides a preparation method of the size-controllable Schiff base-type polymer nano-particle with the 2,6-diaminopyridine and formalin as raw materials. The particle size of the size-controllable Schiff base-type polymer nano-particle can reach 120 nm to lowest. The preparation method is simple and environment-friendly and is carried out entirely in deionized water, has mild and easy-to-control reaction conditions, saves production cost and is easy to carry out in industrial production.