A new method for preparing diarylmethyl substituted phosphonates
A technology of diarylmethyl and arylmethylene is applied in the field of applied catalytic synthesis of organophosphorus compounds, and can solve the problems of harsh reaction conditions, problems of raw material quality, safety, stability and purity, and difficult synthesis techniques, etc. To achieve the effect of mild and easy control of the reaction process, good industrial application prospects, and cheap and easy-to-obtain catalysts
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Embodiment 1
[0023] 99.6 mg (0.6 mmol) of triethyl phosphite, 147 mg (0.5 mmol) of 4-phenylmethylene-2,6-di-tert-butyl-2,5-cyclohexadien-1-one , 9.7 mg (0.05 mmol) of silver tetrafluoroborate were added to a Schlenk tube under nitrogen, and 1.0 mL of 1,2-dichloroethane was added under nitrogen. o C stirred the reaction for 3 hours. After the reaction was completed, the yield of the target product was 98% after separation and purification by column chromatography.
Embodiment 2
[0025] 99.6 mg (0.6 mmol) of triethyl phosphite, 154 mg (0.5 mmol) of 4-(4-methylphenyl)methylene-2,6-di-tert-butyl-2,5-cyclohexyl Dien-1-one, 9.7 mg (0.05 mmol) silver tetrafluoroborate were added to a Schlenk tube under nitrogen, 1.0 mL of 1,2-dichloroethane was added under nitrogen, and the mixture was heated to 80 o C stirred the reaction for 3 hours. After the reaction was completed, the yield of the target product was 92% after separation and purification by column chromatography.
Embodiment 3
[0027] 99.6 mg (0.6 mmol) of triethyl phosphite, 175 mg (0.5 mmol) of 4-(4-tert-butylphenyl)methylene-2,6-di-tert-butyl-2,5-cyclo Hexadien-1-one, 9.7 mg (0.05 mmol) silver tetrafluoroborate were added to a Schlenk tube under nitrogen, 1.0 mL of 1,2-dichloroethane was added under nitrogen, and the mixture was heated to 80 o C stirred the reaction for 3 hours. After the reaction was completed, the yield of the target product was 94% after separation and purification by column chromatography.
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