A method for preparing organophosphate compounds by efficiently esterifying p(o)-oh compounds with phenol

Abstract

The invention provides a method for preparing an organophosphate compound through efficient esterification of a P(O)-OH-containing compound and phenol. The method realizes efficient and highly selective synthesis of organophosphate derivatives containing different substituted functional groups. A carbonyl diimidazole compound is used as a condensation reagent, a P(O)-OH-containing compound and phenol are used as reaction substrates, and an organic solvent is added into the reaction system. The catalyst is cheap and easy to acquire, the applicability to the substrate is high, the reaction conditions are mild, safe and reliable, the selectivity of the target product is close to 100% and the yield is 90% or more. The method solves the problem that the traditional method for synthesis of an organophosphate compound containing an aromatic functional group has poor reaction selectivity, complex reaction steps and a low yield, needs reagents harmful for the environment, and has good industrial application prospects. The invention also provides an organophosphate derivative containing different aromatic group substituents.

Description

technical field [0001] The present invention relates to O -Application catalytic synthesis field of aryl substituted organic phosphate compounds, specifically relates to a method for preparing organic phosphate derivatives by efficient esterification reaction between P(O)-OH compounds and phenol. Background technique [0002] contain O -Aryl-substituted organophosphate compounds are an important class of organic compounds and organic intermediate building blocks in organic synthesis. These compounds have good catalytic activity, optical activity and biological activity, making them useful in biology, medicine, optics Active materials and asymmetric catalytic synthesis have a wide range of applications. In addition, phosphorus and organophosphorus compounds are indispensable in life, such as ADP, ATP, RNA, and organophospholipid bilayers in the human body. However, it is difficult to find pure natural organic phosphate compounds in nature, and most of the phosphorus elemen...

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Problems solved by technology

However, the above methods generally use air-sensitive reagents (P(O)-H compounds, carbon tetrachloride, etc.), and there are also problems such as cumbersome experimental steps, expensive catalysts and difficult recycling, harsh reaction conditions, and suitable substrates. Defects such as sexual intercrossing, low yield, and large environmental pollution

[0004] So far, the efficient synthesis of organic phosphate compounds still has the quality of raw materials, the safety of production (compounds such as phosphorus trichloride, phosphorus pentachloride and phosphorus oxychloride are highly corrosive) and the stability and purity of products There are several problems in several aspects, and the synthesis technology is more difficult

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