The invention discloses an acne treatment composition and application thereof and an acne treatment cream containing the acne treatment composition. The acne treatment composition comprises shea butter, Chinese corktree bark extract, salix nigra bark extract, herba portulacae extract, purple perilla extract, asiatic pennywort herb extract and mung bean extract, effectively conditions acne skins and inhibits reproduction of acne, smoothens acne and removes acne marks, and can be applied to skin directly or added into acne treatment products. The acne treatment cream comprises the acne treatment composition, cetearyl alcohol, ethylhexyl palmitate, polydimethylsiloxane, glyceryl stearate, PEG-100 stearate, caprylic / capric triglyceride, propylene glycol, polyacrylamide, polysorbate-60, sorbitan stearate, laurocapram, PEG-20 methl glucse sesquistearate, menthol, borneol, edta disodium, methylparaben, propyl hydroxybenzoate and water. The acne treatment cream prepared by a hypo-allergenic formula is mild and non-irritating, easy to absorb, non-greasy, safe and effective.