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41results about How to "Regulation of proliferation" patented technology
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Method for preparing constructed body from biobrick containing endothelial cells
ActiveCN106039409AOptimal Control StructureGood size controlCompounds screening/testingCompound screeningRegenerative medicineTissue engineering
The invention relates to a method for preparing a constructed body from a biobrick containing endothelial cells, belonging to the technical fields of biology, regenerative medicine, biological printing (e.g., 3D biological printing), tissue engineering, etc. Particularly, the invention relates to a biobrick applicable to biological printing (e.g., 3D biological printing) and tissue engineering, a composition (e.g., biological ink) including the biobrick, a preparation method and application of the biobrick and the constructed body (e.g., a three-dimensional constructed body) including the biobrick or constructed by using the biobrick / biological ink. The biobrick comprises cells, a core wrapping cells (e.g., endothelial cells), and a shell encapsulating the core.
Owner:SICHUAN REVOTEK CO LTD
Application of RSPO3 gene in sow ovarian granulosa cells
ActiveCN110467663AReduce the degree of enrichmentPromote transcriptionArtificial cell constructsNucleic acid vectorH3K4me3Granulosa cell proliferation
The invention discloses an application of an RSPO3 gene in sow ovarian granulosa cells. Two kinds of follicles with diameters of 3-5 mm and 7-10 mm respectively are used as experimental materials, andthe relationship between H3K4me3 and the expression level of genes related to ovarian follicle development is studied by a sequencing technology. The enrichment degree of H3K4me3 in a promoter regionof the RSPO3 gene is found to be significantly different in the follicles with different size by ChIP-Seq; the expression quantity of the RSPO3 gene in the follicles with different size is found to be significantly different by qRT-PCR; promotion of the degree of the H3K4me3 is found to promote transcription of the RSPO3 gene by promoting or inhibiting the degree of H3K4me3 in the sow ovarian granulosa cells, and inhibition of the degree of H3K4me3 is found to inhibit transcription of the RSPO3 gene; the RSPO3 is found to promote the proliferation of the sow ovarian granulosa cells and inhibit the apoptosis of the cells through overexpression or interference of RSPO3.
Owner:SOUTH CHINA AGRI UNIV
Phenylalanine-derived chiral supramolecular hydrogel and application of phenylalanine-derived chiral supramolecular hydrogel
InactiveCN111729622AThere are no defects such as slow transformationEasy to dryOrganic compound preparationOrganic chemistry methodsNanofiberFiber diameter
The invention discloses phenylalanine-derived chiral supramolecular hydrogel and application thereof, wherein the hydrogel forms a three-dimensional network through physical fiber winding, and the fiber aperture of the hydrogel is about 10 microns. The nanofiber in the LPG gel is in a left-handed spiral shape, and the nanofiber in the DPG gel is in a right-handed spiral shape, and the left and right spiral nanofibers have the same fiber diameter (50 + / - 10 nm) and screw pitch (480 + / - 40 nm). The phenylalanine-derived chiral supramolecular hydrogel is applied to the fields of ophthalmology andneuroscience, and is also applied to stem cells (such as retinal stem cells, neural stem cells and the like) derived from ectoderm.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
Oligonucleotide targeting SNHG17 for treating breast cancer
ActiveCN110029107ARegulation of proliferationOrganic active ingredientsAntineoplastic agentsCancer cellEarly breast cancer
The invention provides an oligonucleotide targeting SNHG17 for treating breast cancer. The oligonucleotide comprises at least one of an antisense oligonucleotide and small interfering RNA, wherein thesequence of the antisense oligonucleotide is as shown in SEQ ID NO.1, and the sequence of the small interfering RNA is as shown in SEQ ID NO.2-4. The oligonucleotide can regulate and control the proliferation, metastasis and invasion capability of triple-negative breast cancer cells by targeting and silencing SNHG17 gene or down-regulating the expression of the SNHG17 gene in the triple-negativebreast cancer cells, and finally improve or treat triple-negative breast cancer.
Owner:SHENZHEN PEOPLES HOSPITAL
Biobrick including endothelial cells and application thereof
ActiveCN106039421AOptimal Control StructureGood size controlCompounds screening/testingCompound screeningEngineeringRegenerative medicine
The invention relates to the technical fields of biology, regenerative medicine, biological printing (e.g., 3D biological printing), tissue engineering, etc. Particularly, the invention relates to a biobrick applicable to biological printing (e.g., 3D biological printing) and tissue engineering, a composition (e.g., biological ink) including the biobrick, a preparation method and application of the biobrick and a constructed body (e.g., a three-dimensional constructed body) including the biobrick or constructed by using the biobrick / biological ink. The biobrick comprises cells, a core wrapping cells (e.g., endothelial cells), and a shell encapsulating the core.
Owner:SICHUAN REVOTEK CO LTD
Essence with effects of whitening, defying age and activating skin and preparation method of essence
InactiveCN109125211APromote sheddingPromote regenerationCosmetic preparationsToilet preparationsCAPRYLOYL SALICYLIC ACIDCholesterol
The invention discloses essence with effects of whitening, defying age and activating skin and a preparation method of the essence. The essence comprises the following components: a wetting agent, acrylic (acrylate) / C10-30 alkyl acrylate crosslinked polymers, 2-oleamido-1,3-octodecanediol, mulberry bark extract, irkutsk anemone rhizome extract, persimmon leaf extract, growth-factor-containing lipidosome, capryloyl salicylic acid, cholesterol polyether-24, a thickening agent, a preservative and the balance of deionized water. The essence with effects of whitening, defying age and activating skin disclosed by the invention is scientific in ratio of various components, the various components achieve obvious synergistic effects, and the essence can achieve the effects of efficiently moisturizing, supplying nutrition to skin, promoting skin metabolism, reducing stains, effectively removing lines and wrinkles, retarding skin aging, improving skin sagging, brightening and tightening skin, moisturizing for a long time, enabling the skin to be moisturized, smooth and enriched in elasticity and improving the skin youth.
Owner:陈洁珍
Antitumor combination drug and application thereof in preparation of anti-cancer drug
ActiveCN107412777ARegulation of proliferationPromote divisionOrganic active ingredientsAntineoplastic agentsChlorogenic acidSide effect
The invention discloses an antitumor combination drug and an application thereof in preparation of an anti-cancer drug. The antitumor combination drug is prepared from 10-40 parts by weight of a first preparation and 0.1-10 parts by weight of a second preparation. The invention further discloses an application of chlorogenic acid in preparation of a toxic and side effect inhibitor for the anti-cancer drug, and the anti-cancer drug is a BCR-ABL small-molecule inhibitor. With the adoption of the technical scheme, targeting ability of the BCR-ABL small-molecule inhibitor for chronic granulocytic leukemia can be improved, toxic and side effects of the BCR-ABL small-molecule inhibitor are reduced, and drug resistance of the BCR-ABL small-molecule inhibitor is reversed.
Owner:SICHUAN JIUZHANG BIO TECH CO LTD
Method for constructing plasmids of recombinant human SPINK5 genes and application of plasmids
PendingCN108374022AHigh expressionRegulation of proliferationPeptide/protein ingredientsNucleic acid vectorSerine peptidaseMelanoma
The invention discloses a method for constructing plasmids of recombinant human SPINK5 genes and application of the plasmids. The method and the application have the advantages that the pathogenesis of melanoma with a high fatality rate is deeply explored, further research and development on novel therapeutic targets for inhibiting malignant behavior such as melanoma cell proliferation and invasion are carried out, and accordingly sufficient laboratory bases can be provided to clinical treatment for the melanoma; interference segments of coding genes SPINK5 of a Lympho-Epithelial Kazal-type related inhibitor (LETKI) are constructed and are applied to the aspects of melanoma cell proliferation and invasion, and accordingly novel experimental evidence can be provided to fundamental researchon the melanoma and research and development on clinical therapeutic targets. The full name of the SPINK5 is Serine Peptidase Inhibitor Kazal Type 5.
Owner:信雅生物科技(苏州)有限公司
Adipose-derived stem cell-ECM modified SIS composite engineered bone and preparation method thereof
ActiveCN106963986APromote rapid proliferationRepair damageTissue regenerationProsthesisFiberCell-Extracellular Matrix
The invention discloses an adipose-derived stem cell-ECM modified SIS composite engineered bone and a preparation method thereof. The microstructure of the composite engineered bone comprises an SIS collagen fiber skeleton, human adipose-derived stem cells and an extracellular matrix layer, the extracellular matrix layer is composed of MC3T3-E1 cell guided and secreted matrix protein and polysaccharide, the extracellular matrix layer covers the surface of the SIS collagen fiber skeleton, and human adipose-derived stem cells adhere to the extracellular matrix layer. The composite engineered bone has high mechanical strength and a microstructure highly similar to natural bone, can provide good tissue support at the initial stage of implantation in vivo, can provide excellent bone-formation microenvironment for implantation of stem cells, after implantation, human adipose-derived stem cells can undergo multiplication and osteogenic differentiation rapidly, thus promoting rapid repair of large bone injury. In addition, the composite engineered bone has pure natural and endogenous characteristics, can avoid uncontrollable factors brought about by introduction of exogenous substances / genes and the like, has very good safety, and has wide clinical application prospects in bone regeneration field.
Owner:河南源创生命干细胞库科技有限公司 +1
Compound in category of dihydro quinolines, preparation method, and composition of medication
InactiveCN1958572AGood regulationRegulation of proliferationOrganic chemistryAntineoplastic agentsGrowth factor receptorProtein-Tyrosine Kinases
This invention relates to a method for preparing 2-oxo-3-substituted aminoalkyl-1, 2-dihydroquinoline derivatives and their pharmacological applications. The general structure of the derivatives is shown in formula I, and R1, R2, R3, R4, R5, R6 and n are defined therein. The derivatives can be used as small molecular inhibitor of epithelial growth factor receptor, and can block the activity of phosphorylated functional protein of protein tyrosine kinases to regulate the cell growth, multiplication and differentiation. Therefore, the derivatives have potential applications in anti-tumor drugs.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Symbiotic composition for reducing blood lipid and preparation and application of symbiotic composition
InactiveCN108295097AIncrease the number ofLong validity periodOrganic active ingredientsSugar food ingredientsBlood lipidsGut flora
The invention discloses a symbiotic composition for reducing blood lipid and a preparation and the application of the symbiotic composition. The symbiotic composition for reducing blood lipid comprises prebiotics and probiotics, wherein the weight ratio of the prebiotics to the probiotics is 1-10 to 1-10. By adopting the symbiotic composition disclosed by the invention, physiological bacterial activity of the probiotics can be brought into play, the number of the probiotics can be also selectively and rapidly increased together with the prebiotics, the probiotics are rapid in action speed andlong-lasting in effect, and then the physiological functions of the prebiotics and the probiotics can be brought into play. The symbiotic composition disclosed by the invention is capable of promotingintestinal health, in addition, the probiotics can be rapidly propagated in intestinal tracts under support of corresponding prebiotics, intestinal flora can be regulated, on one hand, the absorptionfunctions of intestinal tracks can be regulated, on the other hand, the content of fat, particularly cholesterol in blood plasma can be reduced. Therefore, the symbiotic composition has a good bloodfat reduction effect.
Owner:云南中京国建投资有限公司
Application of IRF1 (Interferon Regulating Factor 1) in regulating and controlling immune regulation effect of mesenchymal stem cells and product
ActiveCN113980896ARegulation of proliferationComplements immune plasticityPeptide/protein ingredientsAntipyreticAutoimmune conditionAutoimmune disease
The invention discloses an application of an Interferon Regulating Factor 1 (IRF1) in regulating and controlling the immunomodulatory effect of human placenta, amnion and umbilical cord derived mesenchymal stem cells. The immunomodulatory effect is the effect of inhibiting T cell proliferation. The biological characteristics of human amniotic membrane, placenta and umbilical cord derived mesenchymal stem cells are researched by utilizing a single cell sequencing technology, and the IRF1 is found to be highly expressed in the placenta, amniotic membrane and umbilical cord derived mesenchymal stem cells in an inflammatory microenvironment. Transcription factor analysis and in-vitro experimental research further prove that the IRF1 can regulate and control the expression of MSC immunosuppressive molecules IDO1, CD274 and STAT1 and chemotactic factors CXCL9 and CXCL10, and in-vitro T cell proliferation experiments find that the IRF1 can regulate and control the T cell proliferation inhibition effect of the umbilical cord MSC, so that an important theoretical basis and a therapeutic target are provided for treatment of autoimmune diseases.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Traditional Chinese medicine for treating primary liver cancer
InactiveCN101612251APromote regenerationDilated blood vesselsDigestive systemAntineoplastic agentsMedicinal herbsSide effect
The invention discloses a traditional Chinese medicine for treating primary liver cancer. The traditional Chinese medicine comprises the following raw materials proportioning by weight: 20 to 30 parts of oldenlandia diffusa, 20 to 30 parts of lobelia, 20 to 30 parts of agrimonia pilosa, 20 to 30 parts of herba scutellariae barbatae, 10 to 20 parts of morel, 2 to 4 parts of aweto, 8 to 15 parts of flos buddlejae and 10 to 20 parts of glossy privet fruit, which are added with water and decocted into decoction. For a patient with liver ascites, 20 to 30 parts of herba rostellulariae and 10 to 15 parts of areca are added. The traditional Chinese medicine has the advantages of protecting the liver, promoting liver cell regeneration, expanding the blood vessel of the liver, reinforcing the blood circulation in the liver and increasing the blood flow of the liver, thereby improving liver nutrition and oxygen supply and reinforcing the immunological function. The sources of all the medicinal materials are extensive, the medicinal materials can be mostly collected in southern regions, various Chinese herbal medicines are adopted to carry out comprehensive treatment with obvious effect and convenient taking, each prescription composition conforms to the prescription of medicine politics, the synthetic action of each medicine is utilized to treat the liver cancer, so that the traditional Chinese medicine has no toxic or side effect on a human body.
Owner:沈信堂
Method for adjusting and controlling ovarian granular cells based on circ-Atp5BP
InactiveCN113005095ARegulation of proliferationGenetically modified cellsGenital tract cellsGranular cellGranular leucocyte
The invention provides a method for adjusting and controlling ovarian granulosa cells based on circ-Atp5BP. The method comprises the following steps: (1) carrying out inoculation and subculture on nest granulosa cells; and (2) when the cell density is cultured to be 35 to 45 percent, transfecting the circ-Atp5BP gene or the pik3 gene into the nest granular cells. The application of circ-Atp5BP and pik3 in porcine ovarian granular cell proliferation adjustment and the targeting adjustment relation between circ-Atp5BP and pi3k are proved for the first time. The proliferation of the ovarian granular cells can be remarkably adjusted and controlled.
Owner:SICHUAN AGRI UNIV
Method for preparing biobrick containing endothelial cells and biobrick prepared by using same
ActiveCN106039413AOptimal Control StructureGood size controlCompounds screening/testingCompound screeningChemistryTissue engineering
The invention relates to the technical fields of biology, regenerative medicine, biological printing (e.g., 3D biological printing), tissue engineering, etc. Particularly, the invention relates to a biobrick applicable to biological printing (e.g., 3D biological printing) and tissue engineering, a composition (e.g., biological ink) including the biobrick, a preparation method and application of the biobrick and a constructed body (e.g., a three-dimensional constructed body) including the biobrick or constructed by using the biobrick / biological ink. The biobrick comprises cells, a core wrapping cells (e.g., endothelial cells), and a shell encapsulating the core.
Owner:SICHUAN REVOTEK CO LTD
Biological brick containing endothelial cells and application of biological brick
ActiveCN108079384AOptimal Control StructureGood size controlCompounds screening/testingCompound screeningBrickEngineering
The invention relates to the technical fields of biology, regenerative medicine, biological printing (such as 3D biological printing), tissue engineering and the like. Particularly, the invention relates to a biological brick which can be used for biological printing (such as 3D biological printing) and tissue engineering, a composition (such as biological ink) containing the biological brick, a preparation method and application of the biological brick, and a structure (such as a three-dimensional structure) containing the biological brick or constructed by using the biological brick / biological ink, wherein the biological brick comprises cells, a core layer wrapping the cells (such as endothelial cells), and a shell layer packaging the core layer.
Owner:SICHUAN REVOTEK CO LTD
Skin antiallergic composition
InactiveCN107823098ARegulation of proliferationEffective against allergiesCosmetic preparationsToilet preparationsAllergy preventionMedicine
The invention discloses a skin antiallergic composition. The skin antiallergic composition comprises an anti-oxidant, a humectant, an antiinflammatory agent, a sun-screening agent, cucumber juice, towel gourd juice, honey, and water. The skin antiallergic composition is capable of clearing free radicals, maintaining moisture, inhibiting inflammation, absorbing ultraviolet ray, clearing heat, detoxifying, improving skin cell health from a plurality of aspects, and realizing allergy prevention.
Owner:FOSHAN SHIRUI LEADING MATERIAL RES INST GENERAL PARTNERSHIP
Transgenic pig expressing stnfr1-fc genes and the uses thereof
ActiveUS20140026233A1Easy to useSuppress the TNF-α-mediated inflammatory responseAnimal reproductionPeptide/protein ingredientsGroup A - bloodExtracellular Structure
The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-α in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
Owner:SEOUL NAT UNIV R&DB FOUND
Adipose-derived stem cells-ecm modified sis composite engineered bone and its preparation method
ActiveCN106963986BPromote rapid proliferationRepair damageTissue regenerationProsthesisCell-Extracellular MatrixECM Protein
Owner:河南源创生命干细胞库科技有限公司 +1
Method for controlling proliferation of cord blood hematopoietic stem cells and use thereof
InactiveUS20130143322A1Control proliferation and differentiationInhibit proliferation and differentiationBioreactor/fermenter combinationsBiological substance pretreatmentsCord blood stem cellUmbilical cord
Owner:JMS CO LTD
Molecular marker for epithelioid vascular endothelial tumor and detection kit thereof
InactiveCN114774554AEnriched Molecular TypingImprove clinical pathologyMicrobiological testing/measurementDNA/RNA fragmentationNucleotideExon
The invention relates to the technical field of biomedical detection, in particular to a molecular marker PDGFRA-USP46 fusion gene and a kit for epithelioid vascular endothelioma, the molecular marker is the PDGFRA-USP46 fusion gene, and the nucleotide sequence of the molecular marker is as shown in SEQ ID No.1. The fusion gene is formed by fusing the tail end of a PDGFRA gene Exon 16 located on a chromosome 4q12 and the front end of a USP46 gene Exon 2 located on the chromosome 4q12, and belongs to a split-site fusion site in an inversion type. The kit for detecting epithelioid vascular endothelioma based on the one-step qRT-PCR technology can realize absolute quantitative detection of PDGFRA-USP46 mRNA in paraffin-embedded tissues, and is relatively high in sensitivity and specificity and strong in operability and repeatability.
Owner:BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
Application of circular RNA hsa_circ_0004872 in the diagnosis of gastric cancer
ActiveCN110117657BPromote proliferationPromote invasion and metastasisMicrobiological testing/measurementDNA/RNA fragmentationBase JNucleotide
Owner:SHANDONG UNIV
A kind of nursing agent for improving infant skin barrier effect and preparation process thereof
ActiveCN107412089BImprove the barrierIncrease elasticityCosmetic preparationsToilet preparationsNursing careSkin elasticity
Owner:天津盛世永业科技发展有限公司
Novel use of circular RNA hsa_circ_0004872 for gastric cancer therapy
InactiveCN110117658BPromote proliferationPromote invasion and metastasisMicrobiological testing/measurementDNA/RNA fragmentationNucleotideOncology
Novel use of circular RNA hsa_circ_0004872 for gastric cancer therapy. The present invention belongs to the field of molecular biology and provides a circular RNA, the nucleotide sequence of the gene of the circular RNA hsa_circ_0004872 is shown in SEQ ID NO.1, and the circular RNA hsa_circ_0004872 is from the MAPK1 gene of chromosome 22 The 2nd, 3rd, and 4th exons of MAPK1 pre-mRNA are reversely cut, and the AG base at the 3' end of the 4th exon of MAPK1 pre-mRNA is connected with the CT base at the 5' end of the 2nd exon, forming a covalently closed loop shape RNA. The circular RNA hsa_circ_0004872 can be used in the preparation of chemotherapy drugs for gastric cancer.
Owner:SHANDONG UNIV
Application of KMT2D in preparation of antitumor drugs
PendingCN112057608ARegulation of proliferationRegulation of apoptosisPeptide/protein ingredientsTransferasesRibosomal RNA GenesCompound s
The invention discloses an application of KMT2D in the preparation of antitumor drugs, and belongs to the technical field of biological medicines. A protein structure of KMT2D is analyzed through a bioinformatics means, two essentially disordered structures LCD1 and LCD2 of the KMT2D protein are finally obtained through screening, and the influence of the two structures on the KMT2D function is researched by combining the gene editing technology, the change (including mRNA and protein levels) of a KMT2D enzymatic complex is further researched, and thereby a foundation is laid for the deep understanding of a mechanism of KMT2D promoting tumor.
Owner:NANTONG UNIVERSITY
A kind of anti-tumor combination drug and its application in the preparation of anti-cancer drug
ActiveCN107412777BRegulation of proliferationPromote divisionOrganic active ingredientsAntineoplastic agentsChlorogenic acidMyeloid leukemia
Owner:SICHUAN JIUZHANG BIO TECH CO LTD
Application of rspo3 gene in sow ovary granulosa cells
ActiveCN110467663BReduce the degree of enrichmentPromote transcriptionArtificial cell constructsNucleic acid vectorPhysiologyH3K4me3
Owner:SOUTH CHINA AGRI UNIV
Drug for treating rheumatic arthritis and preparation method thereof
InactiveCN108686000AAvoid destructionHigh yield and purityAntipyreticAnalgesicsAdemetionineTinospora sinensis
Owner:FOSHAN HUIMU CHEM TECH CO LTD
A kind of cream and its preparation process for improving the skin barrier effect of infants and young children
ActiveCN107088180BImprove the barrierIncrease elasticityCosmetic preparationsAerosol deliverySkin elasticitySkin Care Product
Owner:天津盛世永业科技发展有限公司
Application of TROAP in preparation of product for detecting prognosis of breast cancer patient subjected to endocrinotherapy
PendingCN111269981ARegulation of proliferationRegulatory functionMicrobiological testing/measurementBiological material analysisEndocrine therapyPharmaceutical drug
The invention provides application of TROAP as a breast cancer endocrinotherapy drug screening molecular marker. It is found that the TROAP gene is related to the occurrence and development of breastcancer, the expression of the TROAP gene in a hormone receptor positive expression breast cancer patient is up-regulated, and after the expression of TROAP is down-regulated, the proliferation abilityof breast cancer MCF-7 cells is weakened. Based on this, the prognosis condition of a breast cancer patient subjected to endocrinotherapy is judged by detecting the expression level of TROAP.
Owner:SHENGJING HOSPITAL OF CHINA MEDICAL UNIV
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