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Phenylalanine-derived chiral supramolecular hydrogel and application of phenylalanine-derived chiral supramolecular hydrogel

A technology of supramolecular hydrogel and phenylalanine, which is applied in the field of tissue engineering and biomedical regeneration, can solve the problems of low cell affinity, easy degradation, chitosan biosolubility and poor electrospinning performance, and achieve high efficiency Proliferation and differentiation, stemness enhancement effect

Inactive Publication Date: 2020-10-02
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

However, PLCL lacks recognition sites for cell adhesion, resulting in low cell affinity, poor biosolubility and electrospinning properties of chitosan, and poor stability, easy degradation, and short retention time in vivo of hyaluronic acid hydrogels. problems that limit the biological applications of such materials
Most of the currently commercialized hydrogels are polymer hydrogels, but due to the complex synthesis of polymer hydrogels, the toxicity of cross-linking agents, the difficulty of biodegradation, and the slow gel-sol transition, etc. [6] , limiting its application in biomaterials such as cell culture and tissue engineering

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  • Phenylalanine-derived chiral supramolecular hydrogel and application of phenylalanine-derived chiral supramolecular hydrogel

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Embodiment Construction

[0045] The technical features of the present invention are further described below in conjunction with the accompanying drawings and specific embodiments.

[0046] The chiral supramolecular hydrogel derived from phenylalanine used in the embodiment of the present invention is shown in formula 1:

[0047]

[0048] The asterisk is where the chiral carbon atom is located, and the asterisk is marked as S or R, where S is a left-handed molecule and R is a right-handed molecule.

[0049] The preparation method of above-mentioned hydrogel, its steps are:

[0050] (1) 1,4-phthaloyl chloride (2.6 g, 13.0 mmol) was dissolved in dry dichloromethane (DCM, 20 mL) and 100 mL of D-phenylalanine methyl ester hydrochloride (6.0 g, 20 mL) was added dropwise. 26.1 mmol) in a solution of dichloromethane and triethylamine (Et3N, 8.0 mL, 58.3 mmol), stir at room temperature for 24 h, remove excess solvent, dissolve the residue in 100 mL of ethanol, collect insoluble material by filtration and d...

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Abstract

The invention discloses phenylalanine-derived chiral supramolecular hydrogel and application thereof, wherein the hydrogel forms a three-dimensional network through physical fiber winding, and the fiber aperture of the hydrogel is about 10 microns. The nanofiber in the LPG gel is in a left-handed spiral shape, and the nanofiber in the DPG gel is in a right-handed spiral shape, and the left and right spiral nanofibers have the same fiber diameter (50 + / - 10 nm) and screw pitch (480 + / - 40 nm). The phenylalanine-derived chiral supramolecular hydrogel is applied to the fields of ophthalmology andneuroscience, and is also applied to stem cells (such as retinal stem cells, neural stem cells and the like) derived from ectoderm.

Description

technical field [0001] The invention relates to a chiral supramolecular material for regulating the proliferation and differentiation of retinal stem cells (RPC), in particular to a material synthesis technology for the preparation and processing of a phenylalanine-derived chiral supramolecular hydrogel, and a material synthesis technology based on The research of the material regulating RPC proliferation and differentiation belongs to the field of biomedical regeneration and tissue engineering. Background technique [0002] Retinal degenerative diseases mainly include age-related degeneration (AMD), retinitis pigmentosa (RP), Stargardt's disease, etc. At present, the treatment of such diseases mainly includes neurotrophic support and protection therapy, retinal prosthesis therapy, gene replacement therapy, drug therapy, optogenetic therapy, etc. [1] . The pathogenesis of retinal degenerative diseases mainly involves the damage and loss of RPE and / or photoreceptor cells fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00A61L27/52A61L27/18A61L27/38C07C231/02C07C231/12C07C233/87
CPCB01J13/0065A61L27/52A61L27/18A61L27/3804C07C231/02C07C231/12C07C233/87A61L2400/06A61L2430/16A61L2430/32C07B2200/07C08L77/04
Inventor 孙娜计菁窦晓秋冯传良
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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