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32results about How to "Reduce foreign body reactions" patented technology

Anti-erosion sorft tissue repair device

The present disclosure relates to surgical implants comprising a bioabsorbable incision reinforcement element, a long-term mesh, and a bioabsorbable coating disposed on the mesh. The surgical implants disclosed herein are useful in a variety of surgical procedures, particularly surgeries involving the pelvic floor. More particularly, the present disclosure relates to surgical implants, wherein an incision reinforcement element comprises a bioabsorbable material that degrades during a first time period, and the coating comprises a bioabsorbable material that degrades in a second time period, and the first time period is shorter than the second time period.
Owner:BVW HLDG

Composite artificial minute vessel stent and preparation method thereof

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.
Owner:WUXI NO 4 PEOPLES HOSPITAL

Biocompatible implantable sensor apparatus and methods

Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and / or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host. Methods of manufacturing the membranes and detectors, including methods to increase reliability, are also disclosed.
Owner:GLYSENS

Nano magnesium/polylactic acid composite material for completely degradable endovascular stent and preparation method thereof

InactiveCN102532835AImprove biological activityReduce intimal hyperplasiaSurgeryInsertion stentIntravascular stent
The invention relates to a nano magnesium / polylactic acid composite material for a completely degradable endovascular stent and a preparation method thereof. The preparation method comprises the following steps: blending and compositing nano magnesium which is used as a reinforcing material with polylactic acid so as to prepare the completely degradable endovascular stent. The stent has good compatibility with a human body, has less possibility of causing inflammatory reaction, can be completely degraded, and has the advantages of stable mechanical property, simple preparation method, low cost and the like.
Owner:ALLEN MEDICAL TECH SERVICE BEIJING

System, apparatus and method for inferring glucose levels within the peritoneum with implantable sensors

A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection. Alternatively they may be associated transdermally with the sensor and some of the electronics being located subdurally. Insulin infusion means are contemplated to respond manually or mechanically to information from the sensors through the CPU. Mechanical response may be automatic. Infusion means may be located subdurally. It is contemplated that the present invention enable revitalization or replacement of fluorescing compounds and glucose oxidase within the sensor assembly.
Owner:BAXTER INT INC +1

Preparation method of multiple drug fiber membrane for reducing foreign body reaction of implant material

The invention belongs to the field of biological materials. A medical implant material can generate a foreign body reaction when entering a human body, and a present, a drug coating for preventing andtreating the foreign body reaction is difficult to delay and control drug release in a drug release process. Aiming at the problems in the prior art, the invention discloses a preparation method of amultiple drug fiber membrane for reducing a foreign body reaction of an implant material. The preparation method comprises the following steps of: firstly, preparing a nano fiber membrane with a 'skin-core' layer structure through a coaxial electrostatic spinning technology; and then spraying polymer microspheres containing an anti-fibrosis drug on the surface of the fiber membrane through a high-voltage electrostatic spraying technology. The preparation method provided by the invention is simple; and the prepared multiple drug fiber membrane has a multiple drug release system, and can realize multiple controlled release of drugs and reduce the foreign body reaction of the implant material.
Owner:WUXI ZHONGKE GUANGYUAN BIOMATERIALS

Composite polypropylene mesh and preparation method thereof

The invention discloses a composite polypropylene mesh. The composite polypropylene mesh is bonded by a polypropylene mesh and a fibroblast growth factor through polydopamine. In the premise condition of not changing the mechanical strength and the surface structure of the original polypropylene mesh, the fibroblast growth factor is grafted on the surface of the polydopamine after the polydopamine is grafted on the surface of the polypropylene mesh, and the composite mesh separation phenomenon cannot be generated. Simultaneously the fibroblast growth factor is hard to degrade in the body, the fibroblast growth can be induced and then the fascia reconstruction is induced.
Owner:海南德拉米克投资有限公司

Stents combined with paclitaxel derivatives

Stents are used in combination with a paclitaxel derivative in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. Suitable implants include vascular stents, esophageal stents, tracheal or bronchial stents, gastrointestinal stents, genital-urinary stents, nasal and sinus stents, and ENT stents.
Owner:ANGIOTECH INT AG (CH)

Silk protein gel-based rotator cuff patch and preparation method thereof

A rotator cuff patch based on fibroin gel comprises a rotator cuff patch body, a fibroin electrostatic spinning membrane serving as a patch base layer, fibroin gel containing Mg < 2 + > ions serving as a load anti-inflammatory drug layer and fibroin gel containing Zn < 2 + > ions serving as a load healing promoting drug layer, and the rotator cuff patch has the full-degradation characteristic, inhibits inflammatory response in the early stage, promotes osteogenesis in the repair period, and has the advantages of being free of side effects, free of side effects and the like. The effect of promoting graft integration is achieved, and the biological safety is higher.
Owner:福州市第二医院

Vascular Stent Which Elutes Amino Acid-Methyl-Ester Derivatives for the Treatment of Vulnerable Plaque and Vascular Disease

This invention provides implantable medical devices that include delivery systems containing amino acid derivatives, and related methods for making and using. More specifically, this invention provides vascular stents with coatings containing methyl ester derivatives of amino acids, and related methods for making and using.
Owner:MEDTRONIC INC

Cellulose gelatin coating-based rotator cuff patch and preparation method thereof

A rotator cuff patch based on a cellulose gelatin coating comprises a rotator cuff patch body, a cellulose electrostatic spinning membrane serving as a patch substrate layer, gelatin containing chondroitin sulfate serving as a load anti-inflammatory drug layer and gelatin containing astragalus extract serving as a load healing promoting drug layer, and the rotator cuff patch can inhibit inflammatory reaction in the early stage, promote tissue regeneration in the repair period and promote healing. The effect of promoting graft integration is achieved.
Owner:福州市第二医院

Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption

The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.
Owner:BVW HLDG

Composite artificial minute vessel stent and preparation method thereof

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.
Owner:WUXI NO 4 PEOPLES HOSPITAL

Keratoprosthesis

The invention discloses a keratoprosthesis. The keratoprosthesis comprises a central opticator and a fixed portion arranged in the periphery, and the keratoprosthesis is characterized in that a hydroxylapatite coating (3) is smeared on a cylinder lateral outer surface of the central opticator and the inner surface of the fixed portion (2) in the keratoprosthesis, and average grain diameter of nanoparticle of the coating is 20 nm. The keratoprosthesis has the advantages that isolation of the coating and an anti-microbial property of the hydroxylapatite are made use of, after smearing the coating and the hydroxylapatite on the cylinder outer surface of the keratoprosthesis opticator and the inner surface of the fixed portion of the periphery of the opticator, a role of killing effect on microorganisms such as germs which are in contact with a cornea and aqueous humor of a patient is thus played by the coating and the hydroxylapatite; due to the fact that the hydroxylapatite can smear the periphery of the keratoprosthesis opticator for a long time, intrinsic characteristics of keratoprosthesis materials are not changed, intrinsic characteristics of the keratoprosthesis are still maintained so that treatment and nursing can reach optimal effects.
Owner:黄一飞 +1

Multi-layer blood vessel stent and preparation method thereof

ActiveCN108852572AAvoid damageProlong antithrombotic timeStentsSurgeryWater solubleLaser cutting
The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.
Owner:乐普(深圳)国际发展中心有限公司

An autographic degradable vascular stent

The invention discloses a self-image degradable vascular stent, comprising a self-image degradable vascular stent, comprising a stent body, a developing layer, a first spinning layer and a second spinning layer, the developing layer is arranged on The outer surface of the stent body, the first spinning layer is wrapped on the outer wall of the stent body, the second spinning layer is arranged on the outside of the first spinning layer, and the preparation method includes (a ) to prepare the stent body; (b) prepare a developing mixed solution, deposit the developing mixed solution on the surface of the stent body to obtain a developing layer, (c) spray the first spinning layer on the outer wall of the stent body, (d) spray the first spinning layer on the stent body A second spinning layer is made on the surface, and the stent body is pressed into the balloon.
Owner:陕西兴泰生物科技有限责任公司

A kind of composite polypropylene mesh and preparation method thereof

The invention provides a composite polypropylene mesh, which is formed by bonding the polypropylene mesh and fibroblast growth factor through polydopamine. In the present invention, under the premise of not changing the mechanical strength and surface structure of the original polypropylene mesh, after grafting polydopamine on the surface of the polypropylene mesh, and then grafting fibroblast growth factor on the surface of the polydopamine, no composite The phenomenon of mesh separation. At the same time, fibroblast growth factor is not easily degraded in vivo and can induce fibroblast growth, thereby inducing fascial reconstruction.
Owner:海南德拉米克投资有限公司

Surface treatment system and method for subcutaneous device

Methods of modifying a medical device and manufacturing a medical device are disclosed. One embodiment of a method of modifying a medical device includes treating a portion of the medical device with cold plasma and functionalizing the plasma-treated portion with a polymer. One embodiment of a method of manufacturing a medical device includes providing a subcutaneous part configured to be positioned subcutaneously in a user and performing a surface treatment on a portion of the subcutaneous part.
Owner:CONVATEC TECH INC

A kind of braided wire for medical use and its preparation method and product

The invention discloses a braided wire for medical use and a preparation method thereof. The braided wire for medical use includes a core layer made of synthetic high molecular polymer wire and a shell layer made of electrospinning. After the implanted medical device prepared from the braided wire is used for treating female pelvic floor dysfunction diseases, since the shell is relatively soft, the friction of the implanted medical device on the tissue can be reduced, and the shell can also stimulate tissue growth , so that the tissue and the wire of the implanted medical device form a staggered wrap, improve the combination of the implanted medical device and the tissue, and further reduce the sliding and friction between the two, so that the erosion and exposure of the existing implanted medical device can be avoided In addition, drug loading on the shell can further reduce the foreign body reaction of implanted medical devices or reduce postoperative bleeding.
Owner:MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD

A kind of multi-layer vascular stent and preparation method thereof

ActiveCN108852572BAvoid damageProlong antithrombotic timeStentsSurgeryMedicineInsertion stent
The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.
Owner:乐普(深圳)国际发展中心有限公司

Anti-inflammatory coatings to improve biocompatibility of neurological implants

ActiveUS20190134277A1Reduced insertion injuryImprove propertiesSurgeryWound drainsBiocompatibility TestingNeurological implant
Neurological implants whose surfaces have been chemically and covalently modified to impart beneficial properties to the neurological implants are described. The neurological implants possess improved biocompatibility compared to a corresponding neurological implant that lacks the chemical modification. Following implantation in a subject, the surface-modified neurological implants induce a lower-foreign body response, compared to a corresponding unmodified product.
Owner:SEATTLE CHILDRENS HOSPITAL +1

Suture line-equipped suture needle for gastrointestinal endoscope surgery

The invention discloses a suture line-equipped suture needle for a gastrointestinal endoscope surgery. The suture needle comprises a suture needle and a suture line connected to a tail end of the suture needle, the tail end of the suture needle is shaped like a hollow tube, the suture line is provided with barbs, and the barbs are arranged on the suture line in a spiral direction; after one end ofthe suture line is inserted into the hollow tube of the tail end of the suture needle, a tube wall of the hollow tube is clamped and pressed, the suture line is connected to the tail end of the suture needle, and the other end of the suture line is provided with a slippage preventing structure. The suture needle for the gastrointestinal endoscope surgery disclosed in the invention is provided with the barb line; the suture needle can be placed in a gastrovascular cavity after going through a narrow and long clamp path and then taken out, and knotting operation can be eliminated.
Owner:上海市嘉定区安亭医院

A microneedle array brain-computer interface device and its preparation method

The invention provides a microneedle array type brain-computer interface device and a preparation method thereof, comprising: using a non-conductive material as an insulating layer between needles, preparing a plurality of through holes in the insulating layer between the needles; preparing a plurality of metal pads on the conductive material layer The conductive material layer is arranged under the insulating layer between the needles, and the upper surface of the conductive material layer is connected to the lower surface of the insulating layer between the needles; the conductive material layer is processed into a micro columnar structure distributed in an array, so that the micro columnar structure Insulate each other; process the micro-columnar structure into a microneedle structure with a needle tip at the bottom to form a microneedle array layer distributed in an array with the needle tip facing down; prepare external leads for connecting external circuits above the microneedle array layer; Electrode points are prepared on the tip of the microneedle array layer; a microneedle array brain-computer interface device is obtained. The invention has the advantages of reducing the process steps of the microneedle array type brain-computer interface device, improving production efficiency and yield, reducing the processing cost of the device, and the like.
Owner:SHANGHAI JIAOTONG UNIV

Method and apparatus for constructing blood vessel in vitro in the tissue project

The present invention discloses the method and apparatus for externally constructing blood vessel tissue engineering. Biomechanical factors are applied to stimulate proliferation of blood vessel smooth muscle, promote directional arranging of blood vessel, increase the contraction characteristic of smooth muscle cell, increase the collagen content in cell-material composition and the expression of actin heavy strand in cell and induce endothelial cell to form stress fiber via stress. The apparatus of the present invention includes reactor and controller and the controller has its signal port connected via wire to solenoid valve to form pulsed water flow and flow rate to simulate internal physiological environment. The apparatus has reasonable structure, stable performance and easy operation, and can perform data processing and analysis can provide enclosed, non-toxic, bacteria-free and oxygen-rich environment for external blood vessel construction.
Owner:上海组织工程研究与开发中心

Tissue integrated drug delivery system

Infusion sets for subcutaneous drug delivery are described herein. The infusion set integrates a bijel-templated material (BTM) into a cannula such that a portion of the BTM protrudes from the cannula tip into the host tissue. The BTM is a porous, polymeric sponge having a co-continuous architecture with consistent curvature throughout non-constricting, interpenetrating channels, which is critical in mitigation of the deleterious host tissue response, vascularization, and flow redistribution in the implant.
Owner:RGT UNIV OF CALIFORNIA

Artificial cornea containing biological materials

The present invention discloses an artificial cornea containing biological materials. The artificial cornea comprises an optical part and a biological material component, the biological material component is composed of the biological materials, the biological materials comprise autogenous materials and / or non-autogenous materials. The novel artificial cornea has good biocompatibility, optical properties and mechanical strength properties, is suitable for recovery treatments of various complex and severe corneal blindness, can use patient's autologous cornea and also donor's cornea as a carrier, and is convenient for large-scale promotion and use.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Auto-developing degradable vascular stent

The invention discloses an auto-developing degradable vascular stent. The auto-developing degradable vascular stent comprises a stent body, a developing layer, a first spinning layer and a second spinning layer; the developing layer is arranged on the outer surface of the stent body, the first spinning layer is wrapped around the outer side wall of the stent body, and the second spinning layer isarranged on the outer side of the first spinning layer. A preparation method comprises the steps of (a) preparing the stent body; (b) preparing a mixed developing solution and depositing the mixed developing solution on the surface of the stent body to prepare the developing layer; (c) spraying the first spinning layer onto the outer side wall of the stent body; (d) preparing the second spinning layer on the surface of the stent body, and pressing the stent body into a ball.
Owner:陕西兴泰生物科技有限责任公司

Powder type hemostatic composition and method for preparing the same

The present invention relates to a powder type hemostatic composition and method for preparing the same, and more specifically, to powder aggregate having porosity obtained by combining powder of biocompatible hemostatic material with a binder and a method for preparing the same, and a powder type hemostatic composition which comprises the powder aggregate and shows improved hemostatic performance as compared with simple powder hemostatic agents, and can be used to a large surface area for hemostasis, or to narrow, thin or other sites to which approach for hemostasis is difficult.
Owner:SAMYANG HLDG CORP
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