32results about How to "Reduce foreign body reactions" patented technology

Zwitterionic microgels, zwitterionic microgel assemblies, their formulations and methods for their use.

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.

The invention discloses a self-image degradable vascular stent, comprising a self-image degradable vascular stent, comprising a stent body, a developing layer, a first spinning layer and a second spinning layer, the developing layer is arranged on The outer surface of the stent body, the first spinning layer is wrapped on the outer wall of the stent body, the second spinning layer is arranged on the outside of the first spinning layer, and the preparation method includes (a ) to prepare the stent body; (b) prepare a developing mixed solution, deposit the developing mixed solution on the surface of the stent body to obtain a developing layer, (c) spray the first spinning layer on the outer wall of the stent body, (d) spray the first spinning layer on the stent body A second spinning layer is made on the surface, and the stent body is pressed into the balloon.

The invention provides a composite polypropylene mesh, which is formed by bonding the polypropylene mesh and fibroblast growth factor through polydopamine. In the present invention, under the premise of not changing the mechanical strength and surface structure of the original polypropylene mesh, after grafting polydopamine on the surface of the polypropylene mesh, and then grafting fibroblast growth factor on the surface of the polydopamine, no composite The phenomenon of mesh separation. At the same time, fibroblast growth factor is not easily degraded in vivo and can induce fibroblast growth, thereby inducing fascial reconstruction.

The invention discloses a braided wire for medical use and a preparation method thereof. The braided wire for medical use includes a core layer made of synthetic high molecular polymer wire and a shell layer made of electrospinning. After the implanted medical device prepared from the braided wire is used for treating female pelvic floor dysfunction diseases, since the shell is relatively soft, the friction of the implanted medical device on the tissue can be reduced, and the shell can also stimulate tissue growth , so that the tissue and the wire of the implanted medical device form a staggered wrap, improve the combination of the implanted medical device and the tissue, and further reduce the sliding and friction between the two, so that the erosion and exposure of the existing implanted medical device can be avoided In addition, drug loading on the shell can further reduce the foreign body reaction of implanted medical devices or reduce postoperative bleeding.

The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.

The invention provides a microneedle array type brain-computer interface device and a preparation method thereof, comprising: using a non-conductive material as an insulating layer between needles, preparing a plurality of through holes in the insulating layer between the needles; preparing a plurality of metal pads on the conductive material layer The conductive material layer is arranged under the insulating layer between the needles, and the upper surface of the conductive material layer is connected to the lower surface of the insulating layer between the needles; the conductive material layer is processed into a micro columnar structure distributed in an array, so that the micro columnar structure Insulate each other; process the micro-columnar structure into a microneedle structure with a needle tip at the bottom to form a microneedle array layer distributed in an array with the needle tip facing down; prepare external leads for connecting external circuits above the microneedle array layer; Electrode points are prepared on the tip of the microneedle array layer; a microneedle array brain-computer interface device is obtained. The invention has the advantages of reducing the process steps of the microneedle array type brain-computer interface device, improving production efficiency and yield, reducing the processing cost of the device, and the like.

The present invention discloses the method and apparatus for externally constructing blood vessel tissue engineering. Biomechanical factors are applied to stimulate proliferation of blood vessel smooth muscle, promote directional arranging of blood vessel, increase the contraction characteristic of smooth muscle cell, increase the collagen content in cell-material composition and the expression of actin heavy strand in cell and induce endothelial cell to form stress fiber via stress. The apparatus of the present invention includes reactor and controller and the controller has its signal port connected via wire to solenoid valve to form pulsed water flow and flow rate to simulate internal physiological environment. The apparatus has reasonable structure, stable performance and easy operation, and can perform data processing and analysis can provide enclosed, non-toxic, bacteria-free and oxygen-rich environment for external blood vessel construction.

Neurological implants whose surfaces have been chemically and covalently modified to impart beneficial properties to the neurological implants are described. The neurological implants possess improved biocompatibility compared to a corresponding neurological implant that lacks the chemical modification. Following implantation in a subject, the surface-modified neurological implants induce a lower-foreign body response, compared to a corresponding unmodified product.