32results about How to "Reduce foreign body reactions" patented technology

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.

Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and / or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host. Methods of manufacturing the membranes and detectors, including methods to increase reliability, are also disclosed.

This invention provides implantable medical devices that include delivery systems containing amino acid derivatives, and related methods for making and using. More specifically, this invention provides vascular stents with coatings containing methyl ester derivatives of amino acids, and related methods for making and using.

Zwitterionic microgels, zwitterionic microgel assemblies, their formulations and methods for their use.

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.

The invention discloses a self-image degradable vascular stent, comprising a self-image degradable vascular stent, comprising a stent body, a developing layer, a first spinning layer and a second spinning layer, the developing layer is arranged on The outer surface of the stent body, the first spinning layer is wrapped on the outer wall of the stent body, the second spinning layer is arranged on the outside of the first spinning layer, and the preparation method includes (a ) to prepare the stent body; (b) prepare a developing mixed solution, deposit the developing mixed solution on the surface of the stent body to obtain a developing layer, (c) spray the first spinning layer on the outer wall of the stent body, (d) spray the first spinning layer on the stent body A second spinning layer is made on the surface, and the stent body is pressed into the balloon.

The invention provides a composite polypropylene mesh, which is formed by bonding the polypropylene mesh and fibroblast growth factor through polydopamine. In the present invention, under the premise of not changing the mechanical strength and surface structure of the original polypropylene mesh, after grafting polydopamine on the surface of the polypropylene mesh, and then grafting fibroblast growth factor on the surface of the polydopamine, no composite The phenomenon of mesh separation. At the same time, fibroblast growth factor is not easily degraded in vivo and can induce fibroblast growth, thereby inducing fascial reconstruction.

Methods of modifying a medical device and manufacturing a medical device are disclosed. One embodiment of a method of modifying a medical device includes treating a portion of the medical device with cold plasma and functionalizing the plasma-treated portion with a polymer. One embodiment of a method of manufacturing a medical device includes providing a subcutaneous part configured to be positioned subcutaneously in a user and performing a surface treatment on a portion of the subcutaneous part.

The invention discloses a braided wire for medical use and a preparation method thereof. The braided wire for medical use includes a core layer made of synthetic high molecular polymer wire and a shell layer made of electrospinning. After the implanted medical device prepared from the braided wire is used for treating female pelvic floor dysfunction diseases, since the shell is relatively soft, the friction of the implanted medical device on the tissue can be reduced, and the shell can also stimulate tissue growth , so that the tissue and the wire of the implanted medical device form a staggered wrap, improve the combination of the implanted medical device and the tissue, and further reduce the sliding and friction between the two, so that the erosion and exposure of the existing implanted medical device can be avoided In addition, drug loading on the shell can further reduce the foreign body reaction of implanted medical devices or reduce postoperative bleeding.

The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.

The invention discloses a suture line-equipped suture needle for a gastrointestinal endoscope surgery. The suture needle comprises a suture needle and a suture line connected to a tail end of the suture needle, the tail end of the suture needle is shaped like a hollow tube, the suture line is provided with barbs, and the barbs are arranged on the suture line in a spiral direction; after one end ofthe suture line is inserted into the hollow tube of the tail end of the suture needle, a tube wall of the hollow tube is clamped and pressed, the suture line is connected to the tail end of the suture needle, and the other end of the suture line is provided with a slippage preventing structure. The suture needle for the gastrointestinal endoscope surgery disclosed in the invention is provided with the barb line; the suture needle can be placed in a gastrovascular cavity after going through a narrow and long clamp path and then taken out, and knotting operation can be eliminated.

The invention provides a microneedle array type brain-computer interface device and a preparation method thereof, comprising: using a non-conductive material as an insulating layer between needles, preparing a plurality of through holes in the insulating layer between the needles; preparing a plurality of metal pads on the conductive material layer The conductive material layer is arranged under the insulating layer between the needles, and the upper surface of the conductive material layer is connected to the lower surface of the insulating layer between the needles; the conductive material layer is processed into a micro columnar structure distributed in an array, so that the micro columnar structure Insulate each other; process the micro-columnar structure into a microneedle structure with a needle tip at the bottom to form a microneedle array layer distributed in an array with the needle tip facing down; prepare external leads for connecting external circuits above the microneedle array layer; Electrode points are prepared on the tip of the microneedle array layer; a microneedle array brain-computer interface device is obtained. The invention has the advantages of reducing the process steps of the microneedle array type brain-computer interface device, improving production efficiency and yield, reducing the processing cost of the device, and the like.

The present invention discloses the method and apparatus for externally constructing blood vessel tissue engineering. Biomechanical factors are applied to stimulate proliferation of blood vessel smooth muscle, promote directional arranging of blood vessel, increase the contraction characteristic of smooth muscle cell, increase the collagen content in cell-material composition and the expression of actin heavy strand in cell and induce endothelial cell to form stress fiber via stress. The apparatus of the present invention includes reactor and controller and the controller has its signal port connected via wire to solenoid valve to form pulsed water flow and flow rate to simulate internal physiological environment. The apparatus has reasonable structure, stable performance and easy operation, and can perform data processing and analysis can provide enclosed, non-toxic, bacteria-free and oxygen-rich environment for external blood vessel construction.

The present invention discloses an artificial cornea containing biological materials. The artificial cornea comprises an optical part and a biological material component, the biological material component is composed of the biological materials, the biological materials comprise autogenous materials and / or non-autogenous materials. The novel artificial cornea has good biocompatibility, optical properties and mechanical strength properties, is suitable for recovery treatments of various complex and severe corneal blindness, can use patient's autologous cornea and also donor's cornea as a carrier, and is convenient for large-scale promotion and use.

The invention discloses an auto-developing degradable vascular stent. The auto-developing degradable vascular stent comprises a stent body, a developing layer, a first spinning layer and a second spinning layer; the developing layer is arranged on the outer surface of the stent body, the first spinning layer is wrapped around the outer side wall of the stent body, and the second spinning layer isarranged on the outer side of the first spinning layer. A preparation method comprises the steps of (a) preparing the stent body; (b) preparing a mixed developing solution and depositing the mixed developing solution on the surface of the stent body to prepare the developing layer; (c) spraying the first spinning layer onto the outer side wall of the stent body; (d) preparing the second spinning layer on the surface of the stent body, and pressing the stent body into a ball.

Neurological implants whose surfaces have been chemically and covalently modified to impart beneficial properties to the neurological implants are described. The neurological implants possess improved biocompatibility compared to a corresponding neurological implant that lacks the chemical modification. Following implantation in a subject, the surface-modified neurological implants induce a lower-foreign body response, compared to a corresponding unmodified product.

The present invention relates to a powder type hemostatic composition and method for preparing the same, and more specifically, to powder aggregate having porosity obtained by combining powder of biocompatible hemostatic material with a binder and a method for preparing the same, and a powder type hemostatic composition which comprises the powder aggregate and shows improved hemostatic performance as compared with simple powder hemostatic agents, and can be used to a large surface area for hemostasis, or to narrow, thin or other sites to which approach for hemostasis is difficult.